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Safety Data Sheet EN

Amphotericin B solubilized

CAS 1397-89-3

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Amphotericin B solubilized
Product Code
A9528

Regulatory Identifiers

CAS Number
1397-89-3 Check regulations →
REACH No.
This product is a mixture. REACH Registration Number see section 3.

Identified Uses

Laboratory chemicals, Manufacture of substances

Uses advised against

For R&D use only. Not for pharmaceutical, household or other uses.

Manufacturers & Suppliers

M

Merck Life Science BV/SRL

manufacturer

Brusselsesteenweg 288, B-3090 OVERIJSE

+32 (0)3 899-1301

Emergency Contacts

CHEMTREC

+(32) 28 083237

Anti-poison centre

070 245245

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

STOT RE Cat. 1 H372

GHS Pictograms

GHS08 - Serious health hazard

GHS08

Hazard Statements

H372 Causes damage to organs through prolonged or repeated exposure.

Precautionary Statements

P260 Do not breathe dust.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P314 Get medical advice/ attention if you feel unwell.
P501 Dispose of contents/ container to an approved waste disposal plant.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture

Amphotericin Bfrom Streptomyces sp.

Chemical Name CAS Number Concentration Hazardous
amphotericin B EC: 215-742-2 1397-89-3 30 - 50% Yes
sodium deoxycholate EC: 206-132-7 302-95-4 30 - 50% Yes

A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, or the annual tonnage does not require a registration. For the full text of the H-Statements mentioned in this Section, see Section 16.

04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

After inhalation: fresh air. Call in physician.

Skin contact

Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

Eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

Ingestion

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Immediate Medical Attention

Call in physician. Call in ophthalmologist.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water, Foam, Carbon dioxide (CO2), Dry powder

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Carbon oxides, Nitrogen oxides (NOx), Oxides of phosphorus, Sodium oxides, Mixture with combustible ingredients. Development of hazardous combustion gases or vapours possible in the event of fire.

Instructions

Suppress (knock down) gases/vapors/mists with a water spray jet.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Evacuate the danger area, observe emergency procedures, consult an expert.

Cleanup methods

Take up dry.

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Work under hood. Do not inhale substance/mixture.

Storage

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. Full contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: Dermatril® (KCL 740 / Aldrich Z677272, Size M). Splash contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: Dermatril® (KCL 740 / Aldrich Z677272, Size M).

Eyes

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Respiratory

required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3

Skin/Body

protective clothing

Environmental

Do not let product enter drains.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Voc Content
---
State Under Standard Conditions
---
Properties Status
---
Vapor Density
---
Boiling Point
No data available
Freezing Point
No data available
Dynamic Viscosity
No data available
Relative Density
No data available
Metal Corrosion
---
Decomposition Temperature
No data available
Cloud Point
---
Lower Explosive Limit
No data available
Physical State Data
solid
Upper Explosive Limit
No data available
Vapor Pressure
No data available
Colour
No data available
Colour Intensity
---
Auto Ignition Temperature
No data available
Solidification Point
---
Kinematic Viscosity
No data available
Evaporation Rate
---
Explosive Limits
---
Bulk Density
---
Softening Point
---
Flash Point
No data available
Partition Coefficient
No data available
Melting Point
No data available
Flammability
No data available
Solubility In Water
No data available
Form
---
Solubility In Fat
---
Physical State
powder
Ph
No data available
Molecular Weight
---
Density
No data available
Relative Evaporation Rate
---
Crystallisation Point
---
Appearance
---
Solubility
---
Odor Threshold
---
Odor
No data available
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Hazardous reactions

Violent reactions possible with:

Avoid

no information available

Incompatible

Oxidizing agents, Strong oxidizing agents, Strong acids

Decomposition

In the event of fire: see section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

No data available

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

Shipping Name
Not dangerous goods
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Amphotericin B solubilized?

The signal word is danger.

What is the physical form of Amphotericin B solubilized?

Amphotericin B solubilized is a powder with no data available color. It has no data available odor.

What is Amphotericin B solubilized used for?

Laboratory chemicals, Manufacture of substances

What are the hazard statements for Amphotericin B solubilized?

This substance has 1 hazard statement:

  • H372: Causes damage to organs through prolonged or repeated exposure.

What is the melting point of Amphotericin B solubilized?

The melting point is No data available and the boiling point is No data available.