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Safety Data Sheet EN

TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol
Product Code
TR 118, TS 120, TB 126, RN 180
Synonyms
Phenol solution

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Nucleic acid extraction solution for tissue, cells, liquids and blood.

Manufacturers & Suppliers

M

Molecular Research Center, Inc.

manufacturer

5645 Montgomery Rd., Cincinnati, Ohio 45212, USA

1-888-841-0900

Emergency Contacts

CHEMTREC

1-800-424-9300

CHEMTREC

1-703-527-3887

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified warning

Hazard Classifications

Acute Tox. Cat. 4 H302
Acute Tox. Cat. 4 H312
Skin Corr. Cat. 1B H314
Acute Tox. Cat. 4 H332
Eye Dam. Cat. 1 H318
STOT RE Cat. 2 H373

GHS Pictograms

GHS05 - Corrosive

GHS05

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

Hazard Statements

H302 Harmful if swallowed
H312 Harmful in contact with skin
H314 Causes skin burns and eye damage
H318 Causes serious eye damage
H332 Harmful if inhaled
H373 May cause damage to target organs through prolonged or repeated

Precautionary Statements

P202 Do not handle until all safety instructions have been read and understood
P233 Keep container tightly closed.
P261 Avoid breathing dust/fumes/gas/mist/vapors/spray
P264 Wash...thoroughly after handling
P270 Do not eat, drink or smoke when using this product
P271 Use in a well-ventilated area
P273 Avoid release to the environment
P280 Wear protective gloves/protective clothing/eye protection/face protection
P301 + P310 If Swallowed: Immediately call a POISON CENTER or doctor/physician.
P301 + P330 + P331 If Swallowed: Rinse mouth. Do not induce vomiting
P303 + P361 + P353 If on skin or hair: Immediately take off all contaminated clothing. Rinse skin with water/shower.
P304 + P340 If Inhaled: Remove victim to fresh air and keep at rest in a comfortable position for breathing
P305 + P351 + P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P361 Remove/Take Off immediately all contaminated clothing.
P403 + P233 Store in well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an approved waste disposal plant.
If on skin: Remove/Take off all contaminated clothing. Wash with plenty of soap and water.
If on clothing: Wash contaminated clothing before reuse.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture
Chemical Name CAS Number Concentration Hazardous
Phenol EC: 203-632-7 108-95-2 50% Yes
Thiocyanate compounds --- 30% No
Nonhazardous ingredients --- 20% No
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Remove from exposure to fresh air immediately. If breathing has stopped, give artificial respiration. Maintain airway and blood pressure and administer oxygen if available. Oxygen should be administration by qualified personnel.

Skin contact

Remove contaminated clothing rapidly and irrigate or wipe exposed areas immediately and repeatedly with low-molecular-weight polyethylene glycol (PEG 300 or PEG 400) which can be diluted to 50% for easier application. Treatment should be continued until there is no detectable odor of TRI Reagent. If PEG is not available, a glycerin solution, olive oil or vegetable oil can be used instead. If these liquids are not available, irrigation with a high-density shower will reduce phenol uptake, but lesser amounts of water will merely dilute the phenol and expand the area of exposure. After treatment with the high-pressure shower, the skin should be washed with soap and water for at least 15 minutes. In case of chemical burns, cover area with sterile, dry dressing, bandage securely, but not too tightly. Double-bag contaminated clothing and personal belongings.

Eye contact

Wash eyes immediately, for at least 15 minutes, with large amounts of water, holding upper and lower lids open. Remove contact lenses, if present and it is easy to do so.

Ingestion

Wash out mouth if vomiting occurs, have person lean forward with head down to avoid breathing in vomit. Do not induce vomiting unless directed to do so by medical personnel. Have conscious person drink several glasses of milk or water.

Immediate Medical Attention

Get medical attention immediately.

Medical Treatment

Treat symptomatically and supportively. For ingestion exposure: give castor oil or other vegetable oil. Give charcoal slurry if conscious. Be prepared for emergency cardiovascular intervention.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use Class B extinguishers (oils, hydrocarbon liquids.) Dry chemical, carbon dioxide, halon, water spray or standard foam (1987 Emergency Response Guidebook, DOT P 5800.4) for larger fires, use water spray, fog or standard foam (1987 Emergency Response Guidebook, DOT P 5800.4)

Specific hazards

Moderate fire hazard when exposed to heat or flame. Vapor-air mixtures are explosive above flash point. Vapors are heavier than air and may travel a considerable distance to a source of ignition and flash back. Phenol is combustible and containers may explode in fire.

Instructions

Fires involving phenol should be fought upwind from the maximum distance possible. Extinguish using agents indicated.

Firefighter Protection

Wear positive pressure self-contained breathing apparatus.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Restrict persons not wearing protective equipment from area. Remove all ignition sources. Neutralize spill with slaked lime, sodium bicarbonate or crushed limestone. Collect powdered material and deposit in sealed containers and dispose of phenol as hazardous waste. Isolate area and deny entry.

Environmental

Prevent additional leakage or spillage if safe to do so. Do not let the liquid to enter drains and avoid discharge into the environment.

Cleanup methods

Neutralize spill with slaked lime, sodium bicarbonate or crushed limestone. Collect powdered material and deposit in sealed containers

Materials: slaked lime, sodium bicarbonate or crushed limestone

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Observe all Federal, state, and local regulations when storing or disposing of this substance.

Storage

Store in an area appropriate for flammables; a cool, dry, well-ventilated location, away from direct sunlight, heat or sources of ignition.

Fire prevention

away from heat or sources of ignition.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Use engineering controls to keep air borne levels below exposure limit (the human olfactory phenol detection limit is about 5 ppm). Area ventilation is generally adequate, but use fume hood if available.

Hands

User must wear appropriate (impervious) clothing and gloves (rubber or neoprene rubber) to prevent any possibility of skin contact with this substance. Lab coats, safety glasses with side shields and gloves should be considered minimum body protection.

Eyes

Do not wear contact lenses while handling this product. Safety glasses should be the minimum eye protection. Wear chemical goggles to reduce exposure to aerosols or mists. Lab coats, safety glasses with side shields and gloves should be considered minimum body protection.

Respiratory

Stacked cartridge for organic vapors (black ANSI color code, NIOSH approved) plus dust, mist (red ANSI color code, NIOSH approved).

Skin/Body

User must wear appropriate (impervious) clothing and gloves (rubber or neoprene rubber) to prevent any possibility of skin contact with this substance. Lab coats, safety glasses with side shields and gloves should be considered minimum body protection.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Relative Density
---
Freezing Point
---
Kinematic Viscosity
---
Dynamic Viscosity
---
Softening Point
---
Flammability
---
Odor
characteristic sweet, medicinal or tar-like
Odor Threshold
---
Density
---
Solubility
Soluble in water, methanol and glycerol; relatively soluble in aqueous alkali hydroxides, and dimethyl sulfoxide.
Evaporation Rate
Not determined
Ph
---
Melting Point
Not applicable
Auto Ignition Temperature
---
Partition Coefficient
---
Boiling Point
110 °C
Physical State Data
liquid
Explosive Limits
---
Vapor Density
---
Solubility In Water
---
Molecular Weight
---
Upper Explosive Limit
---
Flash Point
---
Physical State
Liquid
Colour
Red to maroon
Voc Content
---
Vapor Pressure
>0.35 mmHg at 25 °C
Relative Evaporation Rate
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Appearance
Red to maroon color with a characteristic sweet, medicinal or tar-like odor.
Colour Intensity
---
Solubility In Fat
---
Metal Corrosion
---
Bulk Density
---
Form
---
Decomposition Temperature
---
Properties Status
---
State Under Standard Conditions
---
Lower Explosive Limit
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal temperatures and pressures.

Hazardous reactions

Hazardous polymerization has not been reported to occur under normal temperatures and pressures.

Incompatible

Acetaldehyde, Aluminum and alloys, Aluminum chloride + nitrobenzene, 1,3-butadiene, boron trifluoride, and diethyletherate, Calcium hypochlorite, Formaldehyde, Lead and alloys, Magnesium and alloys, OXIDIZERS (strong), Peroxodisulfuric acid, Peroxomonosulfuric acid, Plastics and rubber coatings, Sodium nitrate + trifluoroacetic acid, Sodium nitrite, Zinc and alloys.

Decomposition

Thermal decomposition products may include toxic oxides of carbon.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
1760
Shipping Name
CORROSIVE LIQUID, N.O.S.
Transport Class
8
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What other names is TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol known by?

TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol is also known as: Phenol solution

What is the hazard signal word for TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?

The signal word is warning.

What is the physical form of TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?

TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol is a liquid appearing as red to maroon color with a characteristic sweet, medicinal or tar-like odor. with red to maroon color. It has characteristic sweet, medicinal or tar-like odor.

What is the solubility of TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?

Soluble in water, methanol and glycerol; relatively soluble in aqueous alkali hydroxides, and dimethyl sulfoxide.

What is TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol used for?

Nucleic acid extraction solution for tissue, cells, liquids and blood.

What are the hazard statements for TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?

This substance has 6 hazard statements:

  • H302: Harmful if swallowed
  • H312: Harmful in contact with skin
  • H314: Causes skin burns and eye damage
  • H318: Causes serious eye damage
  • H332: Harmful if inhaled
  • H373: May cause damage to target organs through prolonged or repeated

What is the melting point of TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?

The melting point is Not applicable and the boiling point is 110 °C.