Identification
Product identifiers, regulatory numbers, and supplier information
Product Information
- Product Name
- TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol
- Product Code
- TR 118, TS 120, TB 126, RN 180
- Synonyms
- Phenol solution
Regulatory Identifiers
- CAS Number
- N/A
Identified Uses
Nucleic acid extraction solution for tissue, cells, liquids and blood.
Manufacturers & Suppliers
Molecular Research Center, Inc.
manufacturer
5645 Montgomery Rd., Cincinnati, Ohio 45212, USA
1-888-841-0900
Emergency Contacts
CHEMTREC
1-800-424-9300
CHEMTREC
1-703-527-3887
Hazard Identification
GHS classification, signal word, pictograms, and hazard statements
Hazard Classifications
GHS Pictograms
GHS05
GHS07
GHS08
Hazard Statements
Precautionary Statements
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Composition / Information on Ingredients
Chemical components, concentration ranges, and hazardous substance identification
| Chemical Name | CAS Number | Concentration | Hazardous |
|---|---|---|---|
| Phenol EC: 203-632-7 | 108-95-2 | 50% | Yes |
| Thiocyanate compounds | --- | 30% | No |
| Nonhazardous ingredients | --- | 20% | No |
First Aid Measures
Emergency procedures for chemical exposure incidents
Remove from exposure to fresh air immediately. If breathing has stopped, give artificial respiration. Maintain airway and blood pressure and administer oxygen if available. Oxygen should be administration by qualified personnel.
Remove contaminated clothing rapidly and irrigate or wipe exposed areas immediately and repeatedly with low-molecular-weight polyethylene glycol (PEG 300 or PEG 400) which can be diluted to 50% for easier application. Treatment should be continued until there is no detectable odor of TRI Reagent. If PEG is not available, a glycerin solution, olive oil or vegetable oil can be used instead. If these liquids are not available, irrigation with a high-density shower will reduce phenol uptake, but lesser amounts of water will merely dilute the phenol and expand the area of exposure. After treatment with the high-pressure shower, the skin should be washed with soap and water for at least 15 minutes. In case of chemical burns, cover area with sterile, dry dressing, bandage securely, but not too tightly. Double-bag contaminated clothing and personal belongings.
Wash eyes immediately, for at least 15 minutes, with large amounts of water, holding upper and lower lids open. Remove contact lenses, if present and it is easy to do so.
Wash out mouth if vomiting occurs, have person lean forward with head down to avoid breathing in vomit. Do not induce vomiting unless directed to do so by medical personnel. Have conscious person drink several glasses of milk or water.
Immediate Medical Attention
Get medical attention immediately.
Medical Treatment
Treat symptomatically and supportively. For ingestion exposure: give castor oil or other vegetable oil. Give charcoal slurry if conscious. Be prepared for emergency cardiovascular intervention.
Firefighting Measures
Extinguishing media, specific hazards, and firefighter protection
Use Class B extinguishers (oils, hydrocarbon liquids.) Dry chemical, carbon dioxide, halon, water spray or standard foam (1987 Emergency Response Guidebook, DOT P 5800.4) for larger fires, use water spray, fog or standard foam (1987 Emergency Response Guidebook, DOT P 5800.4)
Moderate fire hazard when exposed to heat or flame. Vapor-air mixtures are explosive above flash point. Vapors are heavier than air and may travel a considerable distance to a source of ignition and flash back. Phenol is combustible and containers may explode in fire.
Fires involving phenol should be fought upwind from the maximum distance possible. Extinguish using agents indicated.
Firefighter Protection
Wear positive pressure self-contained breathing apparatus.
Accidental Release Measures
Spill cleanup procedures, containment, and environmental protection
Restrict persons not wearing protective equipment from area. Remove all ignition sources. Neutralize spill with slaked lime, sodium bicarbonate or crushed limestone. Collect powdered material and deposit in sealed containers and dispose of phenol as hazardous waste. Isolate area and deny entry.
Prevent additional leakage or spillage if safe to do so. Do not let the liquid to enter drains and avoid discharge into the environment.
Neutralize spill with slaked lime, sodium bicarbonate or crushed limestone. Collect powdered material and deposit in sealed containers
Materials: slaked lime, sodium bicarbonate or crushed limestone
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Handling and Storage
Safe handling precautions, storage conditions, and workplace requirements
Observe all Federal, state, and local regulations when storing or disposing of this substance.
Store in an area appropriate for flammables; a cool, dry, well-ventilated location, away from direct sunlight, heat or sources of ignition.
away from heat or sources of ignition.
Exposure Controls / PPE
Occupational exposure limits, engineering controls, and protective equipment
Use engineering controls to keep air borne levels below exposure limit (the human olfactory phenol detection limit is about 5 ppm). Area ventilation is generally adequate, but use fume hood if available.
User must wear appropriate (impervious) clothing and gloves (rubber or neoprene rubber) to prevent any possibility of skin contact with this substance. Lab coats, safety glasses with side shields and gloves should be considered minimum body protection.
Do not wear contact lenses while handling this product. Safety glasses should be the minimum eye protection. Wear chemical goggles to reduce exposure to aerosols or mists. Lab coats, safety glasses with side shields and gloves should be considered minimum body protection.
Stacked cartridge for organic vapors (black ANSI color code, NIOSH approved) plus dust, mist (red ANSI color code, NIOSH approved).
User must wear appropriate (impervious) clothing and gloves (rubber or neoprene rubber) to prevent any possibility of skin contact with this substance. Lab coats, safety glasses with side shields and gloves should be considered minimum body protection.
Physical and Chemical Properties
Appearance, physical state, melting point, boiling point, and material characteristics
Stability and Reactivity
Chemical stability, hazardous reactions, and incompatible materials
Stable under normal temperatures and pressures.
Hazardous polymerization has not been reported to occur under normal temperatures and pressures.
Acetaldehyde, Aluminum and alloys, Aluminum chloride + nitrobenzene, 1,3-butadiene, boron trifluoride, and diethyletherate, Calcium hypochlorite, Formaldehyde, Lead and alloys, Magnesium and alloys, OXIDIZERS (strong), Peroxodisulfuric acid, Peroxomonosulfuric acid, Plastics and rubber coatings, Sodium nitrate + trifluoroacetic acid, Sodium nitrite, Zinc and alloys.
Thermal decomposition products may include toxic oxides of carbon.
Ecological Information
Environmental toxicity, biodegradation, and bioaccumulation data
The data for this section has not been processed yet.
Disposal Considerations
Waste treatment methods, disposal recommendations, and waste codes
The data for this section has not been processed yet.
Transport Information
UN numbers, shipping names, transport classes, and regulatory requirements
- UN Number
- 1760
- Shipping Name
- CORROSIVE LIQUID, N.O.S.
- Transport Class
- 8
- Packing Group
- II
Regulatory Information
Chemical regulations, safety assessments, and compliance status
The data for this section has not been processed yet.
Frequently Asked Questions
Common questions about safety, handling, and properties
What other names is TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol known by?
TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol is also known as: Phenol solution
What is the hazard signal word for TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?
The signal word is warning.
What is the physical form of TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?
TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol is a liquid appearing as red to maroon color with a characteristic sweet, medicinal or tar-like odor. with red to maroon color. It has characteristic sweet, medicinal or tar-like odor.
What is the solubility of TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?
Soluble in water, methanol and glycerol; relatively soluble in aqueous alkali hydroxides, and dimethyl sulfoxide.
What is TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol used for?
Nucleic acid extraction solution for tissue, cells, liquids and blood.
What are the hazard statements for TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?
This substance has 6 hazard statements:
- H302: Harmful if swallowed
- H312: Harmful in contact with skin
- H314: Causes skin burns and eye damage
- H318: Causes serious eye damage
- H332: Harmful if inhaled
- H373: May cause damage to target organs through prolonged or repeated
What is the melting point of TRI Reagent, TRI Reagent LS, TRI Reagent BD, RNAzol?
The melting point is Not applicable and the boiling point is 110 °C.