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Safety Data Sheet EN

LOCTITE 601

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
LOCTITE 601

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Threadlocker

Manufacturers & Suppliers

H

Henkel Ltd

manufacturer

Wood Lane End, HP2 4RQ Hemel Hempstead, Great Britain

+44 1442 278000

Emergency Contacts

Emergency Contact

+44 (0)1442 278497

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified warning

Hazard Classifications

Skin Irrit. Cat. 2 H315
Eye Irrit. Cat. 2 H319
Skin Sens. Cat. 1 H317
STOT SE Cat. 3 H335

GHS Pictograms

GHS07 - Health hazard

GHS07

Hazard Statements

H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary Statements

P101 If medical advice is needed, have product container or label at hand.
P102 Keep out of reach of children.
P261 Avoid breathing vapors.
P280 Wear protective gloves.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P333 + P313 If skin irritation or rash occurs: Get medical advice/attention.
P337 + P313 If eye irritation persists: Get medical advice/attention.
P501 Dispose of waste and residues in accordance with local authority requirements

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture

Anaerobic Sealant

Chemical Name CAS Number Concentration Hazardous
2,2'-Ethylenedioxydiethyl dimethacrylate EC: 203-652-6 109-16-0 50 - 100% Yes
2-Hydroxyethyl methacrylate EC: 212-782-2 868-77-9 10 - 20% Yes
Coumarone-indene resins 63393-89-5 5 - 10% Yes
Cumene hydroperoxide EC: 201-254-7 80-15-9 0.25 - 2.5% Yes
N,N-Diethyl-p-toluidine EC: 210-345-0 613-48-9 0.1 - 1% Yes
N,N-dimethyl-o-toluidine EC: 210-199-8 609-72-3 0.1 - 1% Yes
methacrylic acid EC: 201-204-4 79-41-4 0.1 - 1% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Move to fresh air. If symptoms persist, seek medical advice.

Symptoms: Irritation, coughing, shortness of breath, chest tightness.

Skin contact

Rinse with running water and soap. Obtain medical attention if irritation persists.

Symptoms: Redness, inflammation, Rash, Urticaria.

Eye contact

Rinse immediately with plenty of running water (for 10 minutes), seek medical attention from a specialist.

Symptoms: Irritation, conjunctivitis.

Ingestion

Rinse mouth, drink 1-2 glasses of water, do not induce vomiting, consult a doctor.

Immediate Medical Attention

See section: Description of first aid measures

Medical Treatment

See section: Description of first aid measures

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Carbon dioxide, foam, powder

Unsuitable media

None known

Specific hazards

Oxides of carbon, oxides of nitrogen, irritating organic vapors.

Instructions

In case of fire, keep containers cool with water spray.

Firefighter Protection

Wear self-contained breathing apparatus and full protective clothing, such as turn-out gear.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Avoid contact with skin and eyes.

Small spill

wipe up with paper towel and place in container for disposal.

Large spill

absorb onto inert absorbent material and place in sealed container for disposal.

Environmental

Do not let product enter drains.

—

Related Products

Similar products with comparable safety profiles

L

LOCTITE 603

---

L

LOCTITE 4011

---

L

LOCTITE 660

---

L

LOCTITE 4011 S

---

L

LOCTITE 641

---

L

LOCTITE 406

---

L

LOCTITE 406

---

L

LOCTITE 406

---

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Use only in well-ventilated areas. Avoid skin and eye contact. Prolonged or repeated skin contact should be avoided.

Storage

Refer to Technical Data Sheet

Hygiene

Wash hands before work breaks and after finishing work. Do not eat, drink or smoke while working. Good industrial hygiene practices should be observed.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Ensure good ventilation/extraction.

Hands

Chemical-resistant protective gloves (EN 374). Suitable materials for short-term contact or splashes (recommended: at least protection index 2, corresponding to > 30 minutes permeation time as per EN 374): nitrile rubber (NBR; >= 0.4 mm thickness) Suitable materials for longer, direct contact (recommended: protection index 6, corresponding to > 480 minutes permeation time as per EN 374): nitrile rubber (NBR; >= 0.4 mm thickness) This information is based on literature references and on information provided by glove manufacturers, or is derived by analogy with similar substances. Please note that in practice the working life of chemical-resistant protective gloves may be considerably shorter than the permeation time determined in accordance with EN 374 as a result of the many influencing factors (e.g. temperature). If signs of wear and tear are noticed then the gloves should be replaced.

Eyes

Wear protective glasses. Protective eye equipment should conform to EN166.

Respiratory

Use only in well-ventilated areas. An approved mask or respirator fitted with an organic vapour cartridge should be worn if the product is used in a poorly ventilated area. Filter type: A (EN 14387)

Skin/Body

Wear suitable protective clothing. Protective clothing should conform to EN 14605 for liquid splashes or to EN 13982 for dusts.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Physical State
liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
liquid, green
Colour
---
Colour Intensity
---
Form
---
Odor
characteristic
Odor Threshold
No data available / Not applicable
Ph
Not applicable
Melting Point
No data available / Not applicable
Boiling Point
No data available / Not applicable
Flash Point
> 100 °C (> 212 °F)
Freezing Point
---
Softening Point
---
Solidification Point
No data available / Not applicable
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No data available / Not applicable
Vapor Pressure
No data available / Not applicable
Vapor Density
---
Relative Density
---
Bulk Density
No data available / Not applicable
Density
1,098 g/cm3
Flammability
No data available / Not applicable
Upper Explosive Limit
No data available / Not applicable
Lower Explosive Limit
No data available / Not applicable
Explosive Limits
---
Auto Ignition Temperature
No data available / Not applicable
Decomposition Temperature
No data available / Not applicable
Solubility
No data available / Not applicable
Partition Coefficient
No data available / Not applicable
Solubility In Water
Not miscible
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
115 - 135 mPa.s (Cone and plate; Instrument: Haake cone and plate, RV1, C35/2"Ti; speed of rotation: 500 min-1)
Kinematic Viscosity
No data available / Not applicable
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under recommended storage conditions.

Reactivity

Reacts with strong oxidants.

Hazardous reactions

See section reactivity

Incompatible

See section reactivity.

Decomposition

carbon oxides. May produce fumes when heated to decomposition. Fumes may contain carbon monoxide and other toxic fumes.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1. Toxicity

Toxicity (Fish): The mixture is classified based on calculation method referring to the classified substances present in the mixture. | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | --- | --- | --- | --- | --- | --- |

Toxicity

Toxicity (Fish): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | 2,2'-Ethylenedioxydiethyl dimethacrylate 109-16-0 | LC50 | 16,4 mg/l | 96 h | Danio rerio | OECD Guideline 203 (Fish, Acute Toxicity Test) |

Toxicity

Toxicity (Fish): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | 2-Hydroxyethyl methacrylate 868-77-9 | LC50 | > 100 mg/l | 96 h | Oryzias latipes | OECD Guideline 203 (Fish, Acute Toxicity Test) |

Toxicity

Toxicity (Fish): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | Coumarone-indene resins 63393-89-5 | LC50 | 10.000 mg/l | 96 h | not specified | OECD Guideline 203 (Fish, Acute Toxicity Test) |

Toxicity

Toxicity (Fish): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | Cumene hydroperoxide 80-15-9 | LC50 | 3,9 mg/l | 96 h | Oncorhynchus mykiss | OECD Guideline 203 (Fish, Acute Toxicity Test) |

12.1 Toxicity

Toxicity (Fish): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | N,N-dimethyl-o-toluidine 609-72-3 | LC 50 | 46 mg/l | 96 h | Fathead minnow (Pimephales promelas) | |

Toxicity

Toxicity (Fish): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | methacrylic acid 79-41-4 | LC50 | 85 mg/l | 96 h | Salmo gairdneri (new name: Oncorhynchus mykiss) | EPA OTS 797.1400 (Fish Acute Toxicity Test) |

Toxicity

Toxicity (Daphnia): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | 2-Hydroxyethyl methacrylate 868-77-9 | EC50 | 380 mg/l | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |

The EC50 for Daphnia magna is 380 mg/l after 48 hours.

Toxicity

Toxicity (Daphnia): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | Cumene hydroperoxide 80-15-9 | EC50 | 18 mg/l | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |

Toxicity

Toxicity (Daphnia): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | methacrylic acid 79-41-4 | EC50 | > 130 mg/l | 48 h | Daphnia magna | EPA OTS 797.1300 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids) |

Chronic toxicity to aquatic invertebrates

2,2'-Ethylenedioxydiethyl dimethacrylate 109-16-0 | NOEC | 32 mg/l | 21 d | Daphnia magna | OECD 211 (Daphnia magna, Reproduction Test)

12.1 Toxicity

Chronic toxicity to aquatic invertebrates: 2-Hydroxyethyl methacrylate 868-77-9 | NOEC | 24,1 mg/l | 21 d | Daphnia magna | OECD 211 (Daphnia magna, Reproduction Test)

Toxicity

Toxicity (Algae): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | 2,2'-Ethylenedioxydiethyl dimethacrylate 109-16-0 | EC50 | > 100 mg/l | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) | | 2,2'-Ethylenedioxydiethyl dimethacrylate 109-16-0 | NOEC | 18,6 mg/l | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |

Toxicity

Toxicity (Algae): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | 2-Hydroxyethyl methacrylate 868-77-9 | EC50 | 836 mg/l | 72 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | OECD Guideline 201 (Alga, Growth Inhibition Test) | | 2-Hydroxyethyl methacrylate 868-77-9 | NOEC | 400 mg/l | 72 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | OECD Guideline 201 (Alga, Growth Inhibition Test) |

Toxicity

Toxicity (Algae): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | Cumene hydroperoxide 80-15-9 | ErC50 | 3,1 mg/l | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |

Toxicity

Toxicity (Algae): | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | methacrylic acid 79-41-4 | NOEC | 8,2 mg/l | 72 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | OECD Guideline 201 (Alga, Growth Inhibition Test) | | methacrylic acid 79-41-4 | EC50 | 45 mg/l | 72 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | OECD Guideline 201 (Alga, Growth Inhibition Test) |

12.1 Toxicity

Toxicity to microorganisms: 2-Hydroxyethyl methacrylate 868-77-9 | EC0 | > 3.000 mg/l | 16 h | Pseudomonas fluorescens | other guideline:

12.2 Persistence and degradability

12.3 Bioaccumulative potential

12.4 Mobility in soil

12.5 Results of PBT and vPvB assessment

12.6 Endocrine disrupting properties

12.7 Other adverse effects

12.1 Toxicity

Toxicity to microorganisms | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | Cumene hydroperoxide 80-15-9 | EC10 | 70 mg/l | 30 min | | not specified |

Toxicity

Toxicity to microorganisms | Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method | | methacrylic acid 79-41-4 | EC10 | 100 mg/l | 17 h | | not specified |

12.2. Persistence and degradability

The product is not biodegradable. | Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method | | --- | --- | --- | --- | --- | --- |

The product is not biodegradable.

12.2. Persistence and degradability

| Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method | | 2,2'-Ethylenedioxydiethyl dimethacrylate 109-16-0 | readily biodegradable | aerobic | 85 % | 28 d | OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test) |

12.2. Persistence and degradability

Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method | 2-Hydroxyethyl methacrylate 868-77-9 | readily biodegradable | aerobic | 92 - 100 % | 14 d | OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))

12.2. Persistence and degradability

| Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method | | Cumene hydroperoxide 80-15-9 | | no data | 0 % | 28 d | OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test) |

12.2. Persistence and degradability

Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method | methacrylic acid 79-41-4 | inherently biodegradable | aerobic | 100 % | 14 d | OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test) | methacrylic acid 79-41-4 | readily biodegradable | aerobic | 86 % | 28 d | OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test) |

12.3. Bioaccumulative potential

Hazardous substances CAS-No. | Bioconcentration factor (BCF) | Exposure time | Temperature | Species | Method |

12.3. Bioaccumulative potential

| Hazardous substances CAS-No. | Bioconcentration factor (BCF) | Exposure time | Temperature | Species | Method | | Cumene hydroperoxide 80-15-9 | 9,1 | | | calculation | OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) |

12.4. Mobility in soil

Cured adhesives are immobile. | Hazardous substances CAS-No. | LogPow | Temperature | Method | | --- | --- | --- | --- | | 2,2'-Ethylenedioxydiethyl dimethacrylate 109-16-0 | 2,3 | | OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method) | | 2-Hydroxyethyl methacrylate 868-77-9 | 0,42 | 25 °C | OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method) | | Cumene hydroperoxide 80-15-9 | 2,16 | | not specified | | methacrylic acid 79-41-4 | 0,93 | 22 °C | OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method) |

12.5. Results of PBT and vPvB assessment

| Hazardous substances CAS-No. | PBT / vPvB | | --- | --- | | 2,2'-Ethylenedioxydiethyl dimethacrylate 109-16-0 | Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria. | | 2-Hydroxyethyl methacrylate 868-77-9 | Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria. | | Cumene hydroperoxide 80-15-9 | Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria. | | methacrylic acid 79-41-4 | Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria. |

12.6. Other adverse effects

No data available.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Collection and delivery to recycling enterprise or other registered elimination institution.

Disposal

Dispose of in accordance with local and national regulations.

Waste Codes

08 04 09 waste adhesives and sealants containing organic solvents and other dangerous substances EWC
14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for LOCTITE 601?

The signal word is warning.

What is the physical form of LOCTITE 601?

LOCTITE 601 is a liquid appearing as liquid, green . It has characteristic odor.

What is the solubility of LOCTITE 601?

No data available / Not applicable

What is LOCTITE 601 used for?

Threadlocker

What are the hazard statements for LOCTITE 601?

This substance has 4 hazard statements:

  • H315: Causes skin irritation.
  • H317: May cause an allergic skin reaction.
  • H319: Causes serious eye irritation.
  • H335: May cause respiratory irritation.

What is the melting point of LOCTITE 601?

The melting point is No data available / Not applicable and the boiling point is No data available / Not applicable.