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Safety Data Sheet EN

Cycloheximide

CAS 66-81-9
EC 200-636-0

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Cycloheximide
Product Code
J66901
Chemical Name
Cycloheximide
Synonyms
Actidione

Regulatory Identifiers

CAS Number
66-81-9 Check regulations →
EC Number
200-636-0 Check regulations →

Identified Uses

Laboratory chemicals.

Uses advised against

No Information available

Manufacturers & Suppliers

T

Thermo Fisher (Kandel) GmbH

manufacturer

Erlenbachweg 2, 76870 Kandel, Germany

+49 (0) 721 84007 280

Fisher Scientific AG logo

Fisher Scientific AG

distributor

Neuhofstrasse 11, CH 4153 Reinach

+41 (0) 56 618 41 11

https://www.fishersci.ch/ch/en/customer-help-support/forms/email-us.html

Emergency Contacts

Emergency Contact

001-800-227-6701

Emergency Contact

+32 14 57 52 11

Emergency Contact

001-201-796-7100

Emergency Contact

+32 14 57 52 99

CHEMTREC

001-800-424-9300

CHEMTREC

001-703-527-3887

Tox Info Suisse

145

24hr

Tox Info Suisse

+41-44 251 51 51

Chemtrec

0800 564 402

Chemtrec

+41-43 508 20 11

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Acute Tox. Cat. 2 H300
Muta. Cat. 2 H341
Repr. Cat. 1B H360D
Aquatic Chronic Cat. 2 H411

GHS Pictograms

GHS06 - Acute toxicity

GHS06

GHS08 - Serious health hazard

GHS08

GHS09 - Environmental hazard

GHS09

Hazard Statements

H300 Fatal if swallowed
H341 Suspected of causing genetic defects
H360D May damage the unborn child
H411 Toxic to aquatic life with long lasting effects

Precautionary Statements

P201 Obtain special instructions before use
P264 Wash face, hands and any exposed skin thoroughly after handling
P280 Wear protective gloves/protective clothing/eye protection/face protection
P301 + P330 + P331 IF SWALLOWED: rinse mouth. Do NOT induce vomiting
P308 + P313 IF exposed or concerned: Get medical advice/attention
P405 Store locked up

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Cycloheximide EC: 200-636-0 66-81-9 95% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Remove to fresh air. If not breathing, give artificial respiration. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Immediate medical attention is required.

Skin contact

Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

Eye contact

In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Ingestion

Do NOT induce vomiting. Call a physician or poison control center immediately.

Immediate Medical Attention

Immediate medical attention is required.

Medical Treatment

Treat symptomatically.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam.

Unsuitable media

No information available.

Specific hazards

Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition.

Firefighter Protection

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas.

Environmental

Do not flush into surface water or sanitary sewer system.

Cleanup methods

Sweep up and shovel into suitable containers for disposal.

Materials: suitable containers

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Avoid dust formation. Use only under a chemical fume hood. Do not breathe (dust, vapor, mist, gas). Do not ingest. If swallowed then seek immediate medical assistance.

Storage

Keep containers tightly closed in a dry, cool and well-ventilated place.

Hygiene

Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do not eat, drink or smoke when using this product. Remove and wash contaminated clothing and gloves, including the inside, before re-use. Wash hands before breaks and after work.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source

Hands

Protective gloves. Glove material: Nitrile rubber, Neoprene, Natural rubber, PVC. Breakthrough time: See manufacturers recommendations. EU standard: EN 374. Glove comments: (minimum requirement)

Eyes

Goggles (European standard - EN 166)

Respiratory

When workers are facing concentrations above the exposure limit they must use appropriate certified respirators. To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly. Large scale/emergency use: Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended Filter type: Particulates filter conforming to EN 143. Small scale/Laboratory use: Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended half mask: Particle filtering: EN149:2001. When RPE is used a face piece Fit Test should be conducted

Skin/Body

Wear appropriate protective gloves and clothing to prevent skin exposure. Inspect gloves before use. observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. (Refer to manufacturer/supplier for information) gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g. sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion. gloves with care avoiding skin contamination.

Environmental

Prevent product from entering drains. Do not allow material to contaminate ground water system.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
Powder Solid
Physical State Data
solid
State Under Standard Conditions
---
Appearance
Beige
Colour
---
Colour Intensity
---
Form
---
Odor
No information available
Odor Threshold
No data available
Ph
No information available
Melting Point
107 - 114 °C / 224.6 - 237.2 °F
Boiling Point
No information available
Flash Point
No information available
Freezing Point
---
Softening Point
No data available
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
Not applicable - Solid
Vapor Pressure
No data available
Vapor Density
Not applicable
Relative Density
---
Bulk Density
No data available
Density
No data available
Flammability
No information available
Upper Explosive Limit
---
Lower Explosive Limit
---
Explosive Limits
---
Auto Ignition Temperature
Not applicable
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
Cycloheximide: 0.55
Solubility In Water
2.1 g/100ml (2 °C)
Solubility In Fat
---
Molecular Weight
281.35
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
---
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

None known, based on information available

Hazardous reactions

Hazardous polymerization does not occur. None under normal processing.

Avoid

Avoid dust formation. Incompatible products. Excess heat.

Incompatible

Strong oxidizing agents. Strong bases. Acid anhydrides. Acid chlorides.

Decomposition

Nitrogen oxides (NOx). Carbon monoxide (CO). Carbon dioxide (CO₂).

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1. Toxicity

Ecotoxicity effects Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. The product contains following substances which are hazardous for the environment.

12.2. Persistence and degradability

Persistence Deratization in sewage treatment plant Persistence is unlikely. Contains substances known to be hazardous to the environment or not degradable in waste water treatment plants.

12.3. Bioaccumulative potential

Bioaccumulation is unlikely | Component | log Pow | Bioconcentration factor (BCF) | | --- | --- | --- |

12.3. Bioaccumulative potential

| Component | log Pow | Bioconcentration factor (BCF) | | --- | --- | --- | | Cycloheximide | 0.55 | No data available |

12.4. Mobility in soil

The product is water soluble, and may spread in water systems. Will likely be mobile in the environment due to its water solubility. Highly mobile in soils

12.5. Results of PBT and vPvB assessment

No data available for assessment.

12.6. Endocrine disrupting properties

Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors

12.7. Other adverse effects

Persistent Organic Pollutant Ozone Depletion Potential This product does not contain any known or suspected substance This product does not contain any known or suspected substance
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations.

Disposal

Waste is classified as hazardous.

Waste Codes

Not product specific Waste Codes are not product specific, but application specific. EWC
14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
UN2811
Shipping Name
TOXIC SOLID, ORGANIC, N.O.S.
Transport Class
6.1
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

?

Frequently Asked Questions

Common questions about safety, handling, and properties

What other names is Cycloheximide known by?

Cycloheximide is also known as: Actidione

What is the hazard signal word for Cycloheximide?

The signal word is danger.

What is the physical form of Cycloheximide?

Cycloheximide is a powder solid appearing as beige . It has no information available odor.

What is Cycloheximide used for?

Laboratory chemicals.

What are the hazard statements for Cycloheximide?

This substance has 4 hazard statements:

  • H300: Fatal if swallowed
  • H341: Suspected of causing genetic defects
  • H360D: May damage the unborn child
  • H411: Toxic to aquatic life with long lasting effects

What is the melting point of Cycloheximide?

The melting point is 107 - 114 °C / 224.6 - 237.2 °F and the boiling point is No information available.