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Safety Data Sheet EN

Sevoflurane

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Sevoflurane
Product Code
1612540
Chemical Name
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Specified quality tests and assay use only.

Uses advised against

Not for use as a drug. Not for administration to humans or animals.

Manufacturers & Suppliers

U. S. Pharmacopeia logo

U. S. Pharmacopeia

manufacturer

12601 Twinbrook Parkway, Rockville, MD 20852-1790, US

301-816-8129

http://www.usp.org

Emergency Contacts

CHEMTREC within US & Canada

1-800-424-9300

CHEMTREC outside US & Canada

+1 703-527-3887

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified warning

Hazard Classifications

Eye Irrit. Cat. 2A
Repr. Cat. 2
STOT SE Cat. 3

GHS Pictograms

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

Hazard Statements

H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
H361 Suspected of damaging fertility or the unborn child.

Precautionary Statements

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P233 Keep container tightly closed.
P261 Avoid breathing mist or vapor.
P264 Wash thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304 + P340 If inhaled: Remove person to fresh air and keep comfortable for breathing.
P305 + P351 + P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313 If exposed or concerned: Get medical advice/attention.
P312 Call a poison center/doctor if you feel unwell.
P337 + P313 If eye irritation persists: Get medical advice/attention.
P403 Store in a well-ventilated place.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type Substance
Chemical Name CAS Number Concentration Hazardous
Sevoflurane 28523-86-6 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Call a physician if symptoms develop or persist.

Symptoms: Difficulty breathing.

Skin contact

Rinse skin with water/shower. Get medical attention if irritation develops and persists.

Symptoms: Irritation.

Eye contact

Rinse with water. Get medical attention if irritation develops and persists.

Symptoms: Irritation of eyes.

Ingestion

Rinse mouth. If ingestion of a large amount does occur, call a poison control center immediately.

Symptoms: Irritation of mucous membranes. Narcotic effects.

Immediate Medical Attention

Call a physician if symptoms develop or persist (inhalation). Get medical attention if irritation develops and persists (skin/eye). If ingestion of a large amount does occur, call a poison control center immediately. Persons developing serious hypersensitivity (anaphylactic) reactions must receive immediate medical attention.

Medical Treatment

Provide general supportive measures and treat symptomatically. Treatment of halogenated hydrocarbon anesthetic overdose may include the following: Perform gastric lavage soon after ingestion (within 1 hour). Administer activated charcoal as a slurry. For circulatory depression or severe hypotension, infuse isotonic fluids and place in Trendelenburg position. If hypotension persists, administer dopamine or norepinephrine. For bradycardia, administer atropine. For respiratory depression, establish a clear airway and administer 100% oxygen. For malignant hyperthermia, administer 100% oxygen and dantrolene sodium, and reduce body temperature with external cooling methods, if needed. For metabolic acidosis, administer sodium bicarbonate. For hyperkalemia, administer oxygen, bicarbonate, and glucose and insulin. For bronchospasms and wheezing, administer a bronchodilator. For seizures, administer a benzodiazepine. If seizures persist, administer phenobarbital or propofol.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

The data for this section has not been processed yet.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

The data for this section has not been processed yet.

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Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

The data for this section has not been processed yet.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Airborne exposure should be controlled primarily by engineering controls such as general dilution ventilation, local exhaust ventilation, or process enclosure. Local exhaust ventilation is generally preferred to general exhaust because it can control the contaminant at its source, preventing dispersion into the work area. An industrial hygiene survey involving air monitoring may be used to determine the effectiveness of engineering controls. Effectiveness of engineering controls intended for use with highly potent materials should be assessed by use of nontoxic surrogate materials.

Hands

Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy.

Eyes

Safety glasses with sideshields are recommended. Face shields or goggles may be required if splash potential exists or if corrosive materials are present. Approved eye protection (e.g., bearing the ANSI Z87 or CSA stamp) is preferred. Maintain eyewash facilities in the work area.

Respiratory

Where respirators are deemed necessary to reduce or control occupational exposures, use NIOSH-approved respiratory protection and have an effective respirator program in place (applicable U.S. regulation OSHA 29 CFR 1910.134).

Skin/Body

For handling of laboratory scale quantities, a cloth lab coat is recommended. Where significant quantities are handled, work clothing may be necessary to prevent take-home contamination.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Colour Intensity
---
Kinematic Viscosity
---
Partition Coefficient
Not available.
Physical State Data
liquid
Appearance
Clear, colorless, volatile liquid.
Auto Ignition Temperature
Not available.
Vapor Density
6.94 (Air = 1)
Density
1.52 - 1.525
Evaporation Rate
- 1
Odor Threshold
Not available.
Solubility In Fat
---
Relative Density
1.1
Ph
7 - 7.5
Form
Liquid.
Freezing Point
32 - 77 F (0 - 25 C)
Crystallisation Point
---
Cloud Point
---
Bulk Density
---
Softening Point
---
Molecular Weight
200.05
State Under Standard Conditions
---
Upper Explosive Limit
Not available.
Flash Point
Not available.
Solidification Point
---
Vapor Pressure
25.73 kPa at 25 C 197 - 200 mm Hg
Lower Explosive Limit
Not available.
Boiling Point
136.4 - 137.48 F (58 - 58.6 C)
Properties Status
---
Metal Corrosion
---
Solubility
Soluble in ethanol, in chloroform, and in ether; miscible with petroleum benzene.
Melting Point
32 - 77 F (0 - 25 C)
Physical State
Liquid.
Voc Content
---
Solubility In Water
Slightly soluble.
Odor
Nonpungent odor.
Flammability
Not applicable.
Explosive Limits
---
Colour
colorless
Dynamic Viscosity
---
Decomposition Temperature
Not available.
Relative Evaporation Rate
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

The data for this section has not been processed yet.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
UN3334
Shipping Name
Aviation regulated liquid, n.o.s. (Sevoflurane)
Transport Class
9
Packing Group
III
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Sevoflurane?

The signal word is warning.

What is the physical form of Sevoflurane?

Sevoflurane is a liquid. appearing as clear, colorless, volatile liquid. with colorless color. It has nonpungent odor. odor.

What is the solubility of Sevoflurane?

Soluble in ethanol, in chloroform, and in ether; miscible with petroleum benzene.

What is Sevoflurane used for?

Specified quality tests and assay use only.

What are the hazard statements for Sevoflurane?

This substance has 3 hazard statements:

  • H319: Causes serious eye irritation.
  • H336: May cause drowsiness or dizziness.
  • H361: Suspected of damaging fertility or the unborn child.

What is the melting point of Sevoflurane?

The melting point is 32 - 77 F (0 - 25 C) and the boiling point is 136.4 - 137.48 F (58 - 58.6 C).