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Safety Data Sheet EN

Doxorubicin (hydrochloride)

CAS 25316-40-9
EC 246-818-3

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Doxorubicin (hydrochloride)
Product Code
15007
Chemical Name
(8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride
Synonyms
DOX

Regulatory Identifiers

CAS Number
25316-40-9 Check regulations →
EC Number
246-818-3 Check regulations →

Identified Uses

This product is for research use - Not for human or veterinary diagnostic or therapeutic use.

Manufacturers & Suppliers

C

Cayman Chemical Co.

manufacturer

1180 E. Ellsworth Rd., Ann Arbor, MI 48108, USA

Emergency Contacts

Emergency Contact

+1 (734) 971-3335

During normal opening times

US/CANADA

800-424-9300

Outside US/CANADA

703-741-5970

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Carc. Cat. 1B H350
Acute Tox. Cat. 4 H302

GHS Pictograms

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

Hazard Statements

H302 Harmful if swallowed.
H350 May cause cancer.

Precautionary Statements

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P312 If swallowed: Call a poison center/doctor if you feel unwell.
P308 + P313 IF exposed or concerned: Get medical advice/attention.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Doxorubicin (hydrochloride) EC: 246-818-3 25316-40-9 --- No
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Supply fresh air; consult doctor in case of complaints.

Skin contact

Generally the product does not irritate the skin.

Eye contact

Rinse opened eye for several minutes under running water.

Ingestion

Immediately call a doctor.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use fire fighting measures that suit the environment.

Unsuitable media

A solid water stream may be inefficient.

Specific hazards

No further relevant information available.

Firefighter Protection

No special measures required.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Not required.

Environmental

Do not allow to enter sewers/ surface or ground water.

Cleanup methods

Dispose contaminated material as waste according to section 13.

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Ensure good ventilation/exhaustion at the workplace.

Storage

Store in accordance with information listed on the product insert.

Fire prevention

No special measures required.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

No further data; see section 7.

Hands

Protective gloves. The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation. The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.

Eyes

Tightly sealed goggles

Respiratory

In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

State Under Standard Conditions
---
Solubility In Fat
---
Appearance
Form: Solid, Color: Not determined.
Flammability
Product is not flammable.
Voc Content
---
Lower Explosive Limit
Not determined.
Cloud Point
---
Freezing Point
---
Melting Point
Undetermined.
Evaporation Rate
Not applicable.
Explosive Limits
---
Vapor Pressure
Not applicable.
Physical State Data
solid
Solubility In Water
Not determined.
Colour
Not determined.
Density
Not determined.
Ph
Not applicable.
Odor Threshold
Not determined.
Boiling Point
Undetermined.
Physical State
Solid
Molecular Weight
580 g/mol
Upper Explosive Limit
Not determined.
Metal Corrosion
---
Bulk Density
---
Relative Density
Not determined.
Auto Ignition Temperature
Not determined.
Colour Intensity
---
Vapor Density
Not applicable.
Partition Coefficient
Not determined.
Relative Evaporation Rate
---
Flash Point
Not applicable.
Crystallisation Point
---
Odor
Characteristic
Dynamic Viscosity
Not applicable.
Solubility
DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): >100μg/ml
Form
Solid
Kinematic Viscosity
Not applicable.
Softening Point
---
Solidification Point
---
Properties Status
---
Decomposition Temperature
Not determined.
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

No decomposition if used according to specifications.

Reactivity

No further relevant information available.

Hazardous reactions

No dangerous reactions known.

Avoid

No further relevant information available.

Incompatible

strong oxidizing agents

Decomposition

carbon oxides, nitrogen oxides

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Must not be disposed of together with household garbage. Do not allow product to reach sewage system.

Disposal

Must not be disposed of together with household garbage.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
not regulated
Shipping Name
not regulated
Transport Class
Class not regulated
Packing Group
not regulated
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What other names is Doxorubicin (hydrochloride) known by?

Doxorubicin (hydrochloride) is also known as: DOX

What is the hazard signal word for Doxorubicin (hydrochloride)?

The signal word is danger.

What is the physical form of Doxorubicin (hydrochloride)?

Doxorubicin (hydrochloride) is a solid appearing as form: solid, color: not determined. with not determined. color. It has characteristic odor.

What is the solubility of Doxorubicin (hydrochloride)?

DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): >100μg/ml

What is Doxorubicin (hydrochloride) used for?

This product is for research use - Not for human or veterinary diagnostic or therapeutic use.

What are the hazard statements for Doxorubicin (hydrochloride)?

This substance has 2 hazard statements:

  • H302: Harmful if swallowed.
  • H350: May cause cancer.

What is the melting point of Doxorubicin (hydrochloride)?

The melting point is Undetermined. and the boiling point is Undetermined..