Identification
Product identifiers, regulatory numbers, and supplier information
Product Information
- Product Name
- CICLOSPORIN
- Chemical Name
- CICLOSPORIN
- Synonyms
- CYCLO[[E)-(2 S,3 R,4 R)-3-HYDROXY-4-METHYL-2-(METHYLAMINO)-6-OCTEONYL]- L-2-AMINOBUTYRYL-N-METHYLGLYCYL-N-METHYL-L-LEUCYL-L-VALYL-N-METHYL-L-LEUCYL- L-ALANYL-D-ALANYL-N-METHYL-L-LEUCYL-N-METHYL-L-LEUCYL-N-METHYL-L-VALYL] * Cyclosporine
Regulatory Identifiers
- CAS Number
- 59865-13-3 Check regulations →
Identified Uses
Active Pharmaceutical Ingredient. Pharmacological action: Immunosuppressant, Transplantation of organs.
Uses advised against
None known.
Manufacturers & Suppliers
Novartis Pharma AG
manufacturer
Novartis Campus, CH-4056, Basel, Switzerland
Novartis Ireland Limited
importer
Vista Building, Elm Park Business Park, Merrion Road, Dublin 4, Ireland
Emergency Contacts
3E Global Incident
+1 760 476 3962
24 hours a day, 7 days a week, 365 days a year.
Hazard Identification
GHS classification, signal word, pictograms, and hazard statements
Hazard Classifications
GHS Pictograms
GHS07
GHS08
Hazard Statements
Precautionary Statements
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Composition / Information on Ingredients
Chemical components, concentration ranges, and hazardous substance identification
| Chemical Name | CAS Number | Concentration | Hazardous |
|---|---|---|---|
| Cyclosporin | 59865-13-3 | 100% | Yes |
Notes
The full text for all H-statements is displayed in section 16.
First Aid Measures
Emergency procedures for chemical exposure incidents
Move to fresh air. Call a physician if symptoms develop or persist.
Symptoms: Dusts may irritate the respiratory tract.
Wash off with soap and water. Get medical attention if irritation develops and persists.
Symptoms: Dusts may irritate the skin.
Do not rub eyes. Rinse with water. Get medical attention if irritation develops and persists.
Symptoms: Dusts may irritate the eyes.
Rinse mouth. If vomiting occurs, keep head low so that stomach content doesn't get into the lungs. Get medical advice/attention if you feel unwell.
Medical Treatment
Provide general supportive measures and treat symptomatically.
Firefighting Measures
Extinguishing media, specific hazards, and firefighter protection
Avoid high pressure media which could cause the formation of a potentially explosive dust-air mixture. Water fog. Foam. Dry chemical powder. Carbon dioxide (CO2). Apply extinguishing media carefully to avoid creating airborne dust.
Do not use water jet as an extinguisher, as this will spread the fire.
Avoid generating dust; fine dust dispersed in air in sufficient concentrations and in the presence of an ignition source is a potential dust explosion hazard. During fire, gases hazardous to health may be formed.
In case of fire and/or explosion do not breathe fumes. Move containers from fire area if you can do so without risk. Use standard firefighting procedures and consider the hazards of other involved materials.
Firefighter Protection
Self-contained breathing apparatus and full protective clothing must be worn in case of fire.
Accidental Release Measures
Spill cleanup procedures, containment, and environmental protection
For non-emergency personnel: Dust deposits should not be allowed to accumulate on surfaces, as these may form an explosive mixture if they are released into the atmosphere in sufficient concentration. For emergency responders: Keep unnecessary personnel away. Use only non-sparking tools. Ensure adequate ventilation.
Sweep up or vacuum up spillage and collect in suitable container for disposal. Clean surface thoroughly to remove residual contamination.
Wet down with water and dike for later disposal. Shovel the material into waste container. Following product recovery, flush area with water.
Avoid release to the environment. Inform appropriate managerial or supervisory personnel of all environmental releases. Prevent further leakage or spillage if safe to do so.
Related Products
Similar products with comparable safety profiles
Handling and Storage
Safe handling precautions, storage conditions, and workplace requirements
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not taste or swallow. Avoid prolonged exposure. When using, do not eat, drink or smoke. Pregnant or breastfeeding women must not handle this product. Wear appropriate personal protective equipment. Wash hands thoroughly after handling.
Store locked up. Keep containers tightly closed in a dry, cool and well-ventilated place.
When using, do not eat, drink or smoke. Wash hands thoroughly after handling. Observe good industrial hygiene practices.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Exposure Controls / PPE
Occupational exposure limits, engineering controls, and protective equipment
Explosion-proof general and local exhaust ventilation. Good general ventilation should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level. It is recommended that all dust control equipment such as local exhaust ventilation and material transport systems involved in handling of this product contain explosion relief vents or an explosion suppression system or an oxygen-deficient environment. Ensure that dust-handling systems (such as exhaust ducts, dust collectors, vessels, and processing equipment) are designed in a manner to prevent the escape of dust into the work area (i.e., there is no leakage from the equipment). Use only appropriately classified electrical equipment and powered industrial trucks.
Wear appropriate chemical resistant gloves. Select suitable chemical resistant protective gloves (EN 374) with a protective index 6 (>480min permeation time). Nitrile gloves are recommended.
Wear safety glasses with side shields (or goggles).
If engineering controls do not maintain airborne concentrations below recommended exposure limits (where applicable) or to an acceptable level (in countries where exposure limits have not been established), an approved respirator must be worn. Use filtering half-face mask according to EN 140 with filter type 3 (EN143) or disposable fine dust protection mask (EN374).
Wear suitable protective clothing. Use of an impervious apron is recommended.
Inform appropriate managerial or supervisory personnel of all environmental releases. Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. Fume scrubbers, filters or engineering modifications to the process equipment may be necessary to reduce emissions to acceptable levels.
Physical and Chemical Properties
Appearance, physical state, melting point, boiling point, and material characteristics
Stability and Reactivity
Chemical stability, hazardous reactions, and incompatible materials
The product is stable and non-reactive under normal conditions of use, storage and transport.
The product is stable and non-reactive under normal conditions of use, storage and transport.
No dangerous reaction known under conditions of normal use.
Keep away from heat, sparks and open flame. Avoid temperatures exceeding the decomposition temperature. Contact with incompatible materials. Minimise dust generation and accumulation.
Reaction with Water: no violent reaction.
Carbon oxides. Nitrogen oxides (NOx).
Ecological Information
Environmental toxicity, biodegradation, and bioaccumulation data
The data for this section has not been processed yet.
Disposal Considerations
Waste treatment methods, disposal recommendations, and waste codes
The data for this section has not been processed yet.
Transport Information
UN numbers, shipping names, transport classes, and regulatory requirements
Regulatory Information
Chemical regulations, safety assessments, and compliance status
The data for this section has not been processed yet.
Frequently Asked Questions
Common questions about safety, handling, and properties
What other names is CICLOSPORIN known by?
CICLOSPORIN is also known as: CYCLO[[E)-(2 S,3 R,4 R)-3-HYDROXY-4-METHYL-2-(METHYLAMINO)-6-OCTEONYL]- L-2-AMINOBUTYRYL-N-METHYLGLYCYL-N-METHYL-L-LEUCYL-L-VALYL-N-METHYL-L-LEUCYL- L-ALANYL-D-ALANYL-N-METHYL-L-LEUCYL-N-METHYL-L-LEUCYL-N-METHYL-L-VALYL] * Cyclosporine
What is the hazard signal word for CICLOSPORIN?
The signal word is warning.
What is the physical form of CICLOSPORIN?
CICLOSPORIN is a solid. with white color. It has odourless. odor.
What is CICLOSPORIN used for?
Active Pharmaceutical Ingredient. Pharmacological action: Immunosuppressant, Transplantation of organs.
What are the hazard statements for CICLOSPORIN?
This substance has 4 hazard statements:
- H302: Harmful if swallowed.
- H351: Suspected of causing cancer.
- H361: Suspected of damaging fertility or the unborn child.
- H373: May cause damage to organs through prolonged or repeated exposure.
What is the melting point of CICLOSPORIN?
The melting point is 148 - 151 °C (298.4 - 303.8 °F) and the boiling point is Not available..