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Safety Data Sheet EN

Cal 1

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Cal 1

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Laboratory chemicals, Refer to product literature for further details.

Manufacturers & Suppliers

R

Roche Diagnostics Deutschland GmbH

national supplier

Sandhoferstrasse 116 68305 Mannheim Deutschland

+496217590

Emergency Contacts

Central Works Security, Roche Diagnostics GmbH

+49(0)621-759-2203

Centre for detoxification

+49(0)6131-19240

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified warning

Hazard Classifications

Skin Sens. Cat. 1 H317
Aquatic Chronic Cat. 3 H412

GHS Pictograms

GHS07 - Health hazard

GHS07

Hazard Statements

H317 May cause an allergic skin reaction.
H412 Harmful to aquatic life with long lasting effects.

Precautionary Statements

P261 Avoid breathing dust.
P273 Avoid release to the environment.
P280 Wear protective gloves.
P333 + P313 If skin irritation or rash occurs: Get medical advice/ attention.
P362 + P364 Take off contaminated clothing and wash it before reuse.
P501 Dispose of contents/ container to an approved waste disposal plant.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture
Chemical Name CAS Number Concentration Hazardous
2-methyl-2H-isothiazol-3-one hydrochloride EC: 247-499-3 26172-54-3 0.25 - 1% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

If unconscious, place in recovery position and seek medical advice. If symptoms persist, call a physician.

Skin contact

If on skin, rinse well with water.

Symptoms: May cause an allergic skin reaction.

Eye contact

Flush eyes with water as a precaution. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing. If eye irritation persists, consult a specialist.

Ingestion

Keep respiratory tract clear. Do not give milk or alcoholic beverages. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician.

Medical Treatment

Treat symptomatically.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable media

High volume water jet

Firefighter Protection

Wear self-contained breathing apparatus for firefighting if necessary.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Refer to protective measures listed in sections 7 and 8.

Environmental

Prevent product from entering drains. Prevent further leakage or spillage if safe to do so.

Cleanup methods

Keep in suitable, closed containers for disposal.

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid formation of respirable particles. Do not breathe vapours/dust. Avoid exposure - obtain special instructions before use. Avoid contact with skin and eyes. For personal protection see section 8. Smoking, eating and drinking should be prohibited in the application area. Dispose of rinse water in accordance with local and national regulations. Persons susceptible to skin sensitisation problems or asthma, allergies, chronic or recurrent respiratory disease should not be employed in any process in which this mixture is being used.

Storage

Keep container tightly closed in a dry and well-ventilated place. No decomposition if stored and applied as directed.

Hygiene

Wash hands before breaks and at the end of workday.

Fire prevention

Avoid dust formation.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Material : Protective gloves. Remarks : Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. Also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion, and the contact time. This recommendation is only valid for the product mentioned in the safety data sheet and provided by us and for the application specified by us. The suitability for a specific workplace should be discussed with the producers of the protective gloves. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Eyes

Eye wash bottle with pure water. Tightly fitting safety goggles

Skin/Body

Dust impervious protective suit. Choose body protection according to the amount and concentration of the dangerous substance at the work place.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
solid
Physical State Data
solid
State Under Standard Conditions
---
Appearance
---
Colour
light yellow
Colour Intensity
---
Form
solid, (lyophilised)
Odor
characteristic
Odor Threshold
Not applicable
Ph
Not applicable
Melting Point
No data available
Boiling Point
No data available
Flash Point
does not flash
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No data available
Vapor Pressure
---
Vapor Density
---
Relative Density
---
Bulk Density
1.000 - 2.000 g/cm3
Density
---
Flammability
Sustains combustion
Upper Explosive Limit
No data available
Lower Explosive Limit
No data available
Explosive Limits
---
Auto Ignition Temperature
No data available
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
No data available
Solubility In Water
soluble
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
Not applicable
Kinematic Viscosity
Not applicable
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

No dangerous reaction known under conditions of normal use.

Hazardous reactions

No decomposition if stored and applied as directed.

Avoid

No data available

Incompatible

None. Not applicable

Decomposition

No hazardous decomposition products are known.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

Product: Ecotoxicology Assessment Toxicity Data on Soil : Not expected to adsorb on soil. Other organisms relevant to the environment : No data available

12.1 Toxicity

Toxicity to fish: LC50 (Oncorhynchus mykiss (rainbow trout)): 4,77 mg/l, Exposure time: 96 h, Test Type: flow-through test, Method: OECD Test Guideline 203. Toxicity to daphnia and other aquatic invertebrates: EC50 (Daphnia magna (Water flea)): 2,33 mg/l, Exposure time: 48 h, Test Type: static test, Method: OECD Test Guideline 202. Toxicity to algae/aquatic plants: ErC50 (Pseudokirchneriella subcapitata (green algae)): 0,289 mg/l, Exposure time: 72 h, Test Type: static test, Method: OECD Test Guideline 201. M-Factor (Acute aquatic): 1. Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity): NOEC: 0,0442 mg/l, Exposure time: 21 d, Species: Daphnia magna (Water flea), Method: OECD Test Guideline 211. M-Factor (Chronic aquatic toxicity): 1.

12.2 Persistence and degradability

Components: 2-methyl-2H-isothiazol-3-one hydrochloride: Biodegradability : Test Type: aerobic Result: Not readily biodegradable. Biodegradation: 0 % Exposure time: 28 d Method: OECD Test Guideline 301B

12.3 Bioaccumulative potential

Components:

12.3 Bioaccumulative potential

Components: 2-methyl-2H-isothiazol-3-one hydrochloride: Bioaccumulation : Remarks: No bioaccumulation is to be expected (log Pow <= 4). Partition coefficient: n-octanol/water : log Pow: ca. -0,44 (20 °C) Method: OECD Test Guideline 107

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

Assessment : This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

The substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Endocrine disrupting properties

Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

The substance/mixture does not contain components considered to have endocrine disrupting properties at levels of 0.1% or higher.

12.7 Other adverse effects

An environmental hazard cannot be excluded in the event of unprofessional handling or disposal. Harmful to aquatic life with long lasting effects.

An environmental hazard cannot be excluded in the event of unprofessional handling or disposal. Harmful to aquatic life with long lasting effects.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Send to a licensed waste management company.

Disposal

The product should not be allowed to enter drains, water courses or the soil. Do not contaminate ponds, waterways or ditches with chemical or used container.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

Regulatory information for sFlt-1 CalSet including REACH restrictions, German national regulations (WGK, TA Luft), and inventory status.

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Cal 1?

The signal word is warning.

What is the physical form of Cal 1?

Cal 1 is a solid with light yellow color. It has characteristic odor.

What is Cal 1 used for?

Laboratory chemicals, Refer to product literature for further details.

What are the hazard statements for Cal 1?

This substance has 2 hazard statements:

  • H317: May cause an allergic skin reaction.
  • H412: Harmful to aquatic life with long lasting effects.

What is the melting point of Cal 1?

The melting point is No data available and the boiling point is No data available.