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Safety Data Sheet EN

R1

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
R1

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Laboratory chemicals, Refer to product literature for further details.

Manufacturers & Suppliers

R

Roche Diagnostics Deutschland GmbH

national supplier

Sandhoferstrasse 116, 68305 Mannheim, Deutschland

+496217590

Emergency Contacts

Central Works Security, Roche Diagnostics GmbH

+49(0)621-759-2203

Centre for detoxification

+49(0)6131-19240

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified warning

Hazard Classifications

Skin Sens. Cat. 1 H317
Aquatic Chronic Cat. 3 H412

GHS Pictograms

GHS07 - Health hazard

GHS07

Hazard Statements

H317 May cause an allergic skin reaction.
H412 Harmful to aquatic life with long lasting effects.

Precautionary Statements

P261 Avoid breathing mist or vapours.
P273 Avoid release to the environment.
P280 Wear protective gloves.
P333 + P313 If skin irritation or rash occurs: Get medical advice/ attention.
P362 + P364 Take off contaminated clothing and wash it before reuse.
P501 Dispose of contents/ container to an approved waste disposal plant.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture
Chemical Name CAS Number Concentration Hazardous
reaction mass of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-one (3:1) 55965-84-9 0.0025 - 0.025% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

If unconscious, place in recovery position and seek medical advice. If symptoms persist, call a physician.

Skin contact

If on skin, rinse well with water.

Symptoms: May cause an allergic skin reaction.

Eye contact

Flush eyes with water as a precaution. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing.

Ingestion

Keep respiratory tract clear. Do not give milk or alcoholic beverages. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician.

Immediate Medical Attention

If eye irritation persists, consult a specialist.

Medical Treatment

Treat symptomatically.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable media

High volume water jet

Firefighter Protection

Wear self-contained breathing apparatus for firefighting if necessary.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Use personal protective equipment. Refer to protective measures listed in sections 7 and 8.

Environmental

Prevent product from entering drains. Prevent further leakage or spillage if safe to do so. If the product contaminates rivers and lakes or drains inform respective authorities.

Cleanup methods

Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Keep in suitable, closed containers for disposal.

Materials: inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust)

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Do not breathe vapours/dust. Avoid exposure - obtain special instructions before use. Avoid contact with skin and eyes. For personal protection see section 8. Smoking, eating and drinking should be prohibited in the application area. Dispose of rinse water in accordance with local and national regulations. Persons susceptible to skin sensitisation problems or asthma, allergies, chronic or recurrent respiratory disease should not be employed in any process in which this mixture is being used.

Storage

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Hygiene

Wash hands before breaks and at the end of workday.

Fire prevention

Normal measures for preventive fire protection.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Protective gloves. Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. Also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion, and the contact time. This recommendation is only valid for the product mentioned in the safety data sheet and provided by us and for the application specified by us. The suitability for a specific workplace should be discussed with the producers of the protective gloves. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Eyes

Eye wash bottle with pure water. Tightly fitting safety goggles.

Skin/Body

Impervious clothing. Choose body protection according to the amount and concentration of the dangerous substance at the work place.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
---
Colour
No data available
Colour Intensity
---
Form
---
Odor
No data available
Odor Threshold
No data available
Ph
5,5
Melting Point
No data available
Boiling Point
No data available
Flash Point
does not flash
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No data available
Vapor Pressure
No data available
Vapor Density
---
Relative Density
No data available
Bulk Density
---
Density
---
Flammability
The product is not flammable., Does not sustain combustion. Does not sustain combustion.
Upper Explosive Limit
No data available
Lower Explosive Limit
No data available
Explosive Limits
---
Auto Ignition Temperature
No data available
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
No data available
Solubility In Water
completely miscible
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
No data available
Kinematic Viscosity
No data available
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

No dangerous reaction known under conditions of normal use.

Hazardous reactions

No decomposition if stored and applied as directed.

Avoid

No data available

Incompatible

No data available

Decomposition

No hazardous decomposition products are known.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

Product: Ecotoxicology Assessment Toxicity Data on Soil: Not expected to adsorb on soil. Other organisms relevant to the environment: No data available Components: reaction mass of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-one (3:1):

No specific toxicity data provided for the product or components in this section.

12.2 Persistence and degradability

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

No data available

12.6 Endocrine disrupting properties

No data available

12.7 Other adverse effects

No data available

12.1 Toxicity

reaction mass of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-one (3:1): - Toxicity to fish: LC50 (Oncorhynchus mykiss (rainbow trout)): 0,19 mg/l Exposure time: 96 h Test Type: flow-through test - Toxicity to daphnia and other aquatic invertebrates: EC50 (Daphnia magna (Water flea)): 0,16 mg/l Exposure time: 48 h Test Type: flow-through test - Toxicity to algae/aquatic plants: ErC50 (Skeletonema costatum (marine diatom)): 0,0063 mg/l Exposure time: 72 h Test Type: static test Method: OECD Test Guideline 201 - M-Factor (Acute aquatic toxicity): 100 - Toxicity to fish (Chronic toxicity): NOEC: 0,02 mg/l Exposure time: 38 d Species: Cyprinodon sp. (minnow) Test Type: semi-static test Method: OECD Test Guideline 210 - Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity): NOEC: 0,1 mg/l Exposure time: 21 d Species: Daphnia (water flea) GLP: yes - M-Factor (Chronic aquatic): 100

12.2 Persistence and degradability

Components: reaction mass of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-one (3:1): Biodegradability : Result: Inherently biodegradable. Remarks: The 10 day time window criterion is not fulfilled. Result: Not readily biodegradable. Method: OECD Test Guideline 301B GLP: yes

12.3 Bioaccumulative potential

12.3 Bioaccumulative potential

## Components: Bioaccumulation : Species: Lepomis macrochirus (Bluegill sunfish) Temperature: 20 °C Concentration: ca. 0,01 mg/l Bioconcentration factor (BCF): 54 Partition coefficient: n-octanol/water : log Pow: 0,75

12.4 Mobility in soil

No data available

No data available

12.5 Results of PBT and vPvB assessment

Assessment : This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

The substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Endocrine disrupting properties

Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at 13/37 SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006, as amended by Commission Regulation (EU) 2020/878 Roche # VALP2 Version 2.2 Revision Date: 21.04.2026 Date of last issue: 21.04.2026 Date of first issue: 05.07.2012 levels of 0.1% or higher.

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

An environmental hazard cannot be excluded in the event of unprofessional handling or disposal. Harmful to aquatic life with long lasting effects.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Disposal

Send to a licensed waste management company.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

Safety, health and environmental regulations/legislation specific for the substance or mixture

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for R1?

The signal word is warning.

What is the physical form of R1?

R1 is a liquid with no data available color. It has no data available odor.

What is R1 used for?

Laboratory chemicals, Refer to product literature for further details.

What are the hazard statements for R1?

This substance has 2 hazard statements:

  • H317: May cause an allergic skin reaction.
  • H412: Harmful to aquatic life with long lasting effects.

What is the melting point of R1?

The melting point is No data available and the boiling point is No data available.