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Safety Data Sheet EN

PreciControl Thyro Sensitive

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
PreciControl Thyro Sensitive
Product Code
06445918190

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Laboratory chemicals, Refer to product literature for further details.

Manufacturers & Suppliers

R

Roche Diagnostics Deutschland GmbH

manufacturer

Sandhoferstrasse 116, 68305 Mannheim, Deutschland

+496217590

Emergency Contacts

Central Works Security

+49(0)621-759-2203

Centre for detoxification: Mainz

+49(0)6131-19240

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Skin Irrit. Cat. 2 H315
Eye Dam. Cat. 1 H318
Skin Sens. Cat. 1 H317
Aquatic Chronic Cat. 3 H412

GHS Pictograms

GHS05 - Corrosive

GHS05

GHS07 - Health hazard

GHS07

Hazard Statements

H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H412 Harmful to aquatic life with long lasting effects.

Precautionary Statements

P261 Avoid breathing dust.
P264 Wash skin thoroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.
P333 + P313 If skin irritation or rash occurs: Get medical advice/ attention.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture
Chemical Name CAS Number Concentration Hazardous
2-methyl-2H-isothiazol-3-one hydrochloride EC: 247-499-3 26172-54-3 1 - 2.5% Yes
hydroxyl-2-pyridone EC: 212-506-0 822-89-9 1 - 3% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Consult a physician after significant exposure. If unconscious, place in recovery position and seek medical advice.

Skin contact

If skin irritation persists, call a physician. If on skin, rinse well with water. If on clothes, remove clothes.

Symptoms: skin irritation

Eye contact

In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Continue rinsing eyes during transport to hospital. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing. If eye irritation persists, consult a specialist.

Symptoms: Small amounts splashed into eyes can cause irreversible tissue damage and blindness.

Ingestion

Clean mouth with water and drink afterwards plenty of water. Keep respiratory tract clear. Do NOT induce vomiting. Do not give milk or alcoholic beverages. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician. Take victim immediately to hospital.

Immediate Medical Attention

Consult a physician after significant exposure. If skin irritation persists, call a physician. If eye irritation persists, consult a specialist. If symptoms persist, call a physician. Take victim immediately to hospital.

Medical Treatment

Treat symptomatically.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable media

High volume water jet

Specific hazards

Do not allow run-off from fire fighting to enter drains or water courses.

Firefighter Protection

Wear self-contained breathing apparatus for firefighting if necessary.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Refer to protective measures listed in sections 7 and 8.

Environmental

Prevent product from entering drains. Prevent further leakage or spillage if safe to do so. If the product contaminates rivers and lakes or drains inform respective authorities.

Cleanup methods

Keep in suitable, closed containers for disposal.

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid formation of respirable particles. Do not breathe vapours/dust. Avoid exposure - obtain special instructions before use. Avoid contact with skin and eyes. For personal protection see section 8. Smoking, eating and drinking should be prohibited in the application area. Persons susceptible to skin sensitisation problems or asthma, allergies, chronic or recurrent respiratory disease should not be employed in any process in which this mixture is being used.

Storage

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Hygiene

When using do not eat or drink. When using do not smoke. Wash hands before breaks and at the end of workday.

Fire prevention

Avoid dust formation. Provide appropriate exhaust ventilation at places where dust is formed.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

No data available

Hands

Material : In case of contact through splashing: Nitrile rubber. Break through time : > 30 min. Glove thickness : > 0,11 mm. : In case of full contact: Material : butyl-rubber. Break through time : > 480 min. Glove thickness : > 0,4 mm. Remarks : Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. Also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion, and the contact time. This recommendation is only valid for the product mentioned in the safety data sheet and provided by us and for the application specified by us. The suitability for a specific workplace should be discussed with the producers of the protective gloves. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Eyes

Use eye protection according to EN 166. Eye wash bottle with pure water. Tightly fitting safety goggles. Wear face-shield and protective suit for abnormal processing problems.

Respiratory

Use respiratory protection unless adequate local exhaust ventilation is provided or exposure assessment demonstrates that exposures are within recommended exposure guidelines. Equipment should conform to EN 143. Filter type : Particulates type (P)

Skin/Body

Dust impervious protective suit. Choose body protection according to the amount and concentration of the dangerous substance at the work place.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
solid, (lyophilised)
Physical State Data
solid
State Under Standard Conditions
---
Appearance
---
Colour
white, light yellow
Colour Intensity
---
Form
---
Odor
odourless
Odor Threshold
Not applicable
Ph
7,4
Melting Point
No data available
Boiling Point
No data available
Flash Point
does not flash
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No data available
Vapor Pressure
No data available
Vapor Density
---
Relative Density
No data available
Bulk Density
---
Density
1,026 g/cm3
Flammability
---
Upper Explosive Limit
No data available
Lower Explosive Limit
No data available
Explosive Limits
---
Auto Ignition Temperature
No data available
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
No data available
Solubility In Water
soluble
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
Not applicable
Kinematic Viscosity
Not applicable
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

No dangerous reaction known under conditions of normal use.

Hazardous reactions

No decomposition if stored and applied as directed.

Avoid

No data available

Incompatible

Not applicable

Decomposition

No hazardous decomposition products are known.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

Product: Ecotoxicology Assessment Toxicity Data on Soil : Not expected to adsorb on soil. Other organisms relevant to the environment : No data available

12.1 Toxicity

2-methyl-2H-isothiazol-3-one hydrochloride: Toxicity to fish : LC50 (Oncorhynchus mykiss (rainbow trout)): 4,77 mg/l Exposure time: 96 h Test Type: flow-through test Method: OECD Test Guideline 203 The value is given in analogy to the following substances: 2-methylisothiazol-3(2H)-one Toxicity to daphnia and other aquatic invertebrates : EC50 (Daphnia magna (Water flea)): 2,33 mg/l Exposure time: 48 h Test Type: static test Method: OECD Test Guideline 202 Toxicity to algae/aquatic plants : ErC50 (Pseudokirchneriella subcapitata (green algae)): 0,289 mg/l Exposure time: 72 h Test Type: static test Method: OECD Test Guideline 201 M-Factor (Acute aquatic toxicity) : 1 Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity) : NOEC: 0,0442 mg/l Exposure time: 21 d Species: Daphnia magna (Water flea) Method: OECD Test Guideline 211 The value is given in analogy to the following substances: 2-methylisothiazol-3(2H)-one M-Factor (Chronic aquatic toxicity) : 1

12.1 Toxicity

hydroxyl-2-pyridone: Toxicity to fish : LC50 (Lepomis macrochirus (Bluegill sunfish)): > 97,8 mg/l End point: mortality Exposure time: 96 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 203 GLP: yes Toxicity to daphnia and other aquatic invertebrates : EC50 (Daphnia magna (Water flea)): 78,6 mg/l End point: Immobilization Exposure time: 48 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 202 GLP: yes Toxicity to algae/aquatic plants : EC50 (Pseudokirchneriella subcapitata (green algae)): 6,60 mg/l End point: Growth rate Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes Toxicity to microorganisms: EC50 (activated sludge): 320,8 mg/l End point: Respiration inhibition Exposure time: 3 h Test Type: static test Analytical monitoring: no Method: OECD Test Guideline 209 GLP: yes

12.2 Persistence and degradability

2-methyl-2H-isothiazol-3-one hydrochloride: Biodegradability: Test Type: aerobic Result: Not readily biodegradable. Biodegradation: 0 % Exposure time: 28 d Method: OECD Test Guideline 301B

12.2 Persistence and degradability

Biodegradability: Test Type: aerobic Inoculum: activated sludge Concentration: 22,2 mg/l Result: Readily biodegradable. Biodegradation: 94 % Exposure time: 29 d Method: OECD Test Guideline 301B GLP: yes

Readily biodegradable.

12.3 Bioaccumulative potential

2-methyl-2H-isothiazol-3-one hydrochloride: Bioaccumulation: Remarks: No bioaccumulation is to be expected (log Pow <= 4). Partition coefficient: n-octanol/water : log Pow: ca. -0,44 (20 °C) Method: OECD Test Guideline 107

12.3 Bioaccumulative potential

hydroxyl-2-pyridone: Partition coefficient: n-octanol/water : log Pow: -0,489 (25 °C) pH: 4,99 Method: OECD Test Guideline 107 GLP: yes log Pow: -2,73 (25 °C) pH: 9 Method: OECD Test Guideline 107 GLP: yes log Pow: -1,59 (25 °C) pH: 7 Method: OECD Test Guideline 107 GLP: yes

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

Assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

The substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Endocrine disrupting properties

Assessment: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

The substance/mixture does not contain components considered to have endocrine disrupting properties at levels of 0.1% or higher.

12.7 Other adverse effects

Additional ecological information: An environmental hazard cannot be excluded in the event of unprofessional handling or disposal. Harmful to aquatic life with long lasting effects.

An environmental hazard cannot be excluded in the event of unprofessional handling or disposal. Harmful to aquatic life with long lasting effects.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Send to a licensed waste management company.

Disposal

The product should not be allowed to enter drains, water courses or the soil. Do not contaminate ponds, waterways or ditches with chemical or used container.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

Safety, health and environmental regulations/legislation specific for the substance or mixture

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for PreciControl Thyro Sensitive?

The signal word is danger.

What is the physical form of PreciControl Thyro Sensitive?

PreciControl Thyro Sensitive is a solid, (lyophilised) with white, light yellow color. It has odourless odor.

What is PreciControl Thyro Sensitive used for?

Laboratory chemicals, Refer to product literature for further details.

What are the hazard statements for PreciControl Thyro Sensitive?

This substance has 4 hazard statements:

  • H315: Causes skin irritation.
  • H317: May cause an allergic skin reaction.
  • H318: Causes serious eye damage.
  • H412: Harmful to aquatic life with long lasting effects.

What is the melting point of PreciControl Thyro Sensitive?

The melting point is No data available and the boiling point is No data available.