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Safety Data Sheet EN

Dabrafenib (GSK2118436)

CAS 1195765-45-7

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Dabrafenib (GSK2118436)
Product Code
S2807

Regulatory Identifiers

CAS Number
1195765-45-7 Check regulations →

Identified Uses

Laboratory chemicals, manufacture of substances.

Manufacturers & Suppliers

S

Selleck Chemicals

manufacturer

+1 832 582-8158

Emergency Contacts

Emergency Contact

+1 832 582-8158

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified warning

Hazard Classifications

Repr. Cat. 2 H361
STOT RE Cat. 2 H373
Aquatic Acute Cat. 1 H400
Aquatic Chronic Cat. 2 H411

GHS Pictograms

GHS08 - Serious health hazard

GHS08

GHS09 - Environmental hazard

GHS09

Hazard Statements

H361 Suspected of damaging fertility or the unborn child.
H373 Causes damage to organs through prolonged or repeated exposure.
H400 Very toxic to aquatic life.
H411 Toxic to aquatic life with long lasting effects.

Precautionary Statements

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapors/spray.
P273 Avoid release to the environment.
P281 Use personal protective equipment as required.
P308 + P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 1195765-45-7 --- No
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Immediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.

Skin contact

Rinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.

Eye contact

Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.

Ingestion

Wash out mouth with water; Do NOT induce vomiting; call a physician.

Immediate Medical Attention

Promptly call a physician.

Medical Treatment

Treat symptomatically.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use water spray, dry chemical, foam, and carbon dioxide fire extinguisher.

Specific hazards

During combustion, may emit irritant fumes.

Firefighter Protection

Wear self-contained breathing apparatus and protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Use full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.

Environmental

Try to prevent further leakage or spillage. Keep the product away from drains or water courses.

Cleanup methods

Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol

Materials: finely-powdered liquid-binding material (diatomite, universal binders)

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.

Storage

Keep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition. Store at -20°C (powder) or -80°C (in solvent)

Fire prevention

Keep away from sources of ignition.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Ensure adequate ventilation. Provide accessible safety shower and eye wash station.

Hands

Protective gloves.

Eyes

Safety goggles with side-shields.

Respiratory

Suitable respirator.

Skin/Body

Impervious clothing.

Environmental

Keep the product away from drains, water courses or the soil. Clean spillages in a safe way as soon as possible.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
solid
Physical State Data
solid
State Under Standard Conditions
---
Appearance
solid
Colour
---
Colour Intensity
---
Form
---
Odor
No data available
Odor Threshold
No data available
Ph
No data available
Melting Point
No data available
Boiling Point
No data available
Flash Point
No data available
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No data available
Vapor Pressure
No data available
Vapor Density
No data available
Relative Density
No data available
Bulk Density
---
Density
---
Flammability
No data available
Upper Explosive Limit
No data available
Lower Explosive Limit
No data available
Explosive Limits
---
Auto Ignition Temperature
No data available
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
No data available
Solubility In Water
<1 mg/mL
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
No data available
Kinematic Viscosity
No data available
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under recommended storage conditions.

Reactivity

No data available.

Hazardous reactions

No data available.

Avoid

No data available.

Incompatible

Strong acids/alkalis, strong oxidising/reducing agents.

Decomposition

Under fire conditions, may decompose and emit toxic fumes. Other decomposition products - no data available.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

No data available.

No data available.

12.2 Persistence and degradability

No data available.

No data available.

12.3 Bioaccumulative potential

No data available.

No data available.

12.4 Mobility in soil

No data available.

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.

PBT/vPvB assessment is unavailable as a chemical safety assessment was not required or not conducted.

12.6 Other adverse effects

No data available.

No data available.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Dispose substance in accordance with prevailing country, federal, state and local regulations.

Disposal

Dispose substance in accordance with prevailing country, federal, state and local regulations.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
3077
Shipping Name
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Transport Class
9
Packing Group
III
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

No data available.

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Dabrafenib (GSK2118436)?

The signal word is warning.

What is the physical form of Dabrafenib (GSK2118436)?

Dabrafenib (GSK2118436) is a solid appearing as solid . It has no data available odor.

What is Dabrafenib (GSK2118436) used for?

Laboratory chemicals, manufacture of substances.

What are the hazard statements for Dabrafenib (GSK2118436)?

This substance has 4 hazard statements:

  • H361: Suspected of damaging fertility or the unborn child.
  • H373: Causes damage to organs through prolonged or repeated exposure.
  • H400: Very toxic to aquatic life.
  • H411: Toxic to aquatic life with long lasting effects.

What is the melting point of Dabrafenib (GSK2118436)?

The melting point is No data available and the boiling point is No data available.