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Safety Data Sheet EN

Abemaciclib

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Abemaciclib
Product Code
TRC-A115153-10MG

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Laboratory use

Uses advised against

No information available

Manufacturers & Suppliers

T

Toronto Research Chemicals

manufacturer

2 Brisbane Road, Toronto, ON, M3J 2J8

Emergency Contacts

Toronto Research Chemicals

+1(416) 665-9696

0800-1700 (GMT-5)

CHEMTREC

1-800-424-9300

CHEMTREC

+1 703-741-5970

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Repr. Cat. 1B
STOT RE Cat. 2
Aquatic Acute Cat. 1
Aquatic Chronic Cat. 1

GHS Pictograms

GHS08 - Serious health hazard

GHS08

GHS09 - Environmental hazard

GHS09

Hazard Statements

H360 May damage fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
H410 Very toxic to aquatic life with long lasting effects

Precautionary Statements

P201 Obtain special instructions before use
P202 Do not handle until all safety precautions have been read and understood
P261 Do not breathe dust, fume, gas, mist, vapors and spray
P273 Avoid release to the environment
P280 Wear protective gloves, protective clothing, eye protection and face protection
P308 + P313 IF exposed or concerned: Get medical advice/attention
P391 Collect spillage
P405 Store locked up
P501 Dispose of contents and container to an approved waste disposal plant

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Abemaciclib 1231929-97-7 90 - 100% No
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Remove to fresh air.

Skin contact

Wash skin with soap and water.

Eye contact

Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a doctor.

Ingestion

Rinse mouth.

Medical Treatment

Treat symptomatically.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable media

Do not scatter spilled material with high pressure water streams.

Specific hazards

No information available.

Firefighter Protection

Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. Use personal protection equipment.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Ensure adequate ventilation. Use personal protective equipment as required. Evacuate personnel to safe areas.

Cleanup methods

Pick up and transfer to properly labelled containers.

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Handle in accordance with good industrial hygiene and safety practice. Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this product. Remove contaminated clothing and shoes. Ensure adequate ventilation.

Storage

Please refer to the manufacturer's certificate for specific storage and transport temperature conditions. Store only in the original receptacle unless other advice is given on the CoA. Store locked up.

Hygiene

Handle in accordance with good industrial hygiene and safety practice. Do not eat, drink or smoke when using this product. Remove contaminated clothing and shoes.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Showers, Eyewash stations, Ventilation systems.

Hands

The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374. Wear suitable gloves. Wear protective Viton™ gloves.

Eyes

Avoid contact with eyes. Wear safety glasses with side shields (or goggles).

Respiratory

No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required.

Skin/Body

Wear suitable protective clothing.

Environmental

Do not allow into any sewer, on the ground or into any body of water.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Lower Explosive Limit
No data available
Physical State Data
---
Evaporation Rate
No data available
Crystallisation Point
---
Explosive Limits
---
Relative Density
No data available
Boiling Point
No data available
Physical State
No information available
Softening Point
No information available
Decomposition Temperature
---
Melting Point
175 - 178 °C / 347 - 352.4 °F
Solubility In Water
Slightly soluble
Vapor Pressure
No data available
Kinematic Viscosity
No data available
Molecular Weight
506.59
Relative Evaporation Rate
---
Solubility In Fat
---
Cloud Point
---
Freezing Point
175 - 178 °C / 347 - 352.4 °F
State Under Standard Conditions
---
Odor Threshold
No information available
Upper Explosive Limit
No data available
Voc Content
No information available
Flammability
No data available
Properties Status
---
Colour
No information available
Partition Coefficient
No data available
Ph
No data available
Form
---
Colour Intensity
---
Dynamic Viscosity
No data available
Auto Ignition Temperature
No data available
Flash Point
No data available
Vapor Density
---
Density
No information available
Metal Corrosion
---
Bulk Density
No information available
Appearance
No information available
Solidification Point
---
Solubility
No data available
Odor
No information available
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

No information available.

Hazardous reactions

None under normal processing.

Avoid

None known based on information supplied.

Incompatible

None known based on information supplied.

Decomposition

None known based on information supplied.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation.

Disposal

Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
UN3077
Shipping Name
Environmentally hazardous substances, solid, n.o.s. (Abemaciclib)
Transport Class
9
Packing Group
III
IMDG

274, 335, 966, 967, 969

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Abemaciclib?

The signal word is danger.

What is the physical form of Abemaciclib?

Abemaciclib is a no information available appearing as no information available with no information available color. It has no information available odor.

What is the solubility of Abemaciclib?

No data available

What is Abemaciclib used for?

Laboratory use

What are the hazard statements for Abemaciclib?

This substance has 3 hazard statements:

  • H360: May damage fertility or the unborn child
  • H373: May cause damage to organs through prolonged or repeated exposure
  • H410: Very toxic to aquatic life with long lasting effects

What is the melting point of Abemaciclib?

The melting point is 175 - 178 °C / 347 - 352.4 °F and the boiling point is No data available.