NextSDS Logo
Safety Data Sheet EN

Ketoconazole

CAS 65277-42-1

Get a free compliance audit

Upload your SDS inventory and get a detailed compliance report.

Get Free Audit
01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Ketoconazole
Product Code
K1003
Chemical Name
Ketoconazole

Regulatory Identifiers

CAS Number
65277-42-1 Check regulations →
REACH No.
A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

Identified Uses

Laboratory chemicals, Manufacture of substances

Manufacturers & Suppliers

S

Sigma

manufacturer

S

Sigma-Aldrich BVBA/SPRL

manufacturer

Pegasuslaan 5, B-1831 DIEGEM

+32 3 899 1301

Emergency Contacts

Emergency Contact

070 245245

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Acute Tox. Cat. 3 H301
Repr. Cat. 1B H360F
STOT RE Cat. 2 H373
Aquatic Acute Cat. 1 H400
Aquatic Chronic Cat. 1 H410

GHS Pictograms

GHS06 - Acute toxicity

GHS06

GHS08 - Serious health hazard

GHS08

GHS09 - Environmental hazard

GHS09

Hazard Statements

H301 Toxic if swallowed.
H360F May damage fertility.
H373 May cause damage to organs through prolonged or repeated exposure.
H410 Very toxic to aquatic life with long lasting effects.

Precautionary Statements

P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P501 Dispose of contents/ container to an approved waste disposal plant.

Get a free compliance audit

Upload your SDS inventory and get a detailed compliance report

Free Audit
03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Ketoconazole EC: 265-667-4 65277-42-1 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

Skin contact

Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

Eye contact

Flush eyes with water as a precaution.

Ingestion

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Immediate Medical Attention

Consult a physician. Take victim immediately to hospital.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Specific hazards

Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas

Firefighter Protection

Wear self contained breathing apparatus for fire fighting if necessary.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Evacuate personnel to safe areas.

Environmental

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Cleanup methods

Pick up and arrange disposal without creating dust. Sweep up and shovel.

Materials: suitable, closed containers

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.

Storage

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M). Splash contact Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M). data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374. If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Eyes

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Respiratory

Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Skin/Body

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Environmental

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Physical State
solid
Physical State Data
solid
State Under Standard Conditions
---
Appearance
Form: solid Colour: white, light brown
Colour
white, light brown
Colour Intensity
---
Form
solid
Odor
---
Odor Threshold
---
Ph
---
Melting Point
147 °C
Boiling Point
---
Flash Point
---
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
---
Vapor Pressure
---
Vapor Density
---
Relative Density
---
Bulk Density
---
Density
---
Flammability
---
Upper Explosive Limit
---
Lower Explosive Limit
---
Explosive Limits
---
Auto Ignition Temperature
---
Decomposition Temperature
---
Solubility
---
Partition Coefficient
log Pow: 3,507
Solubility In Water
---
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
---
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under recommended storage conditions.

Reactivity

no data available

Hazardous reactions

no data available

Avoid

no data available

Incompatible

Strong oxidizing agents

Decomposition

Other decomposition products - no data available. In the event of fire: see section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
2811
Shipping Name
TOXIC SOLID, ORGANIC, N.O.S. (Ketoconazole)
Transport Class
6.1
Packing Group
III
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Ketoconazole?

The signal word is danger.

What is the physical form of Ketoconazole?

Ketoconazole is a solid appearing as form: solid colour: white, light brown with white, light brown color.

What is Ketoconazole used for?

Laboratory chemicals, Manufacture of substances

What are the hazard statements for Ketoconazole?

This substance has 4 hazard statements:

  • H301: Toxic if swallowed.
  • H360F: May damage fertility.
  • H373: May cause damage to organs through prolonged or repeated exposure.
  • H410: Very toxic to aquatic life with long lasting effects.

What is the melting point of Ketoconazole?

The melting point is 147 °C .