12.1. Toxicity
Toxicity (Fish): The mixture is classified based on calculation method referring to the classified substances present in the mixture.
12.2. Persistence and degradability
12.3. Bioaccumulative potential
12.4. Mobility in soil
12.5. Results of PBT and vPvB assessment
12.6. Endocrine disrupting properties
12.7. Other adverse effects
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Hydrocarbons, C15-C20, n-alkanes, isoalkanes, cyclics, < 0.03% aromatics 1335203-17-2 | LC50 | > 1.028 mg/l | 96 h | Scophthalmus maximus | OECD Guideline 203 (Fish, Acute Toxicity Test) |
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Titanium dioxide 13463-67-7 | LC50 | Toxicity > Water solubility | 48 h | Leuciscus idus | OECD Guideline 203 (Fish, Acute Toxicity Test) |
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| titanium dioxide 1317-70-0 | LC50 | > 1.000 mg/l | 96 h | Fundulus heteroclitus | OECD Guideline 203 (Fish, Acute Toxicity Test) |
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Ti-oxide rutile 1317-80-2 | LC50 | Toxicity > Water solubility | 96 h | Oncorhynchus mykiss | OECD Guideline 203 (Fish, Acute Toxicity Test) |
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Decamethylcyclopentasiloxane 541-02-6 | LC50 | Toxicity > Water solubility | 96 h | Leuciscus idus | OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study) |
| Decamethylcyclopentasiloxane 541-02-6 | NOEC | Toxicity > Water solubility | 90 d | Oncorhynchus mykiss | OECD Guideline 210 (fish early lite stage toxicity test) |
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Dodecamethylcyclohexasiloxane 540-97-6 | NOEC | Toxicity > Water solubility | 90 d | Oncorhynchus mykiss | OECD Guideline 210 (fish early lite stage toxicity test) |
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Dioctyltin dilaurate 3648-18-8 | LC50 | Toxicity > Water solubility | 96 h | | OECD Guideline 203 (Fish, Acute Toxicity Test) |
12.1. Toxicity
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| octamethylcyclotetrasiloxane 556-67-2 | NOEC | 0.0044 mg/l | 93 d | Salmo gairdneri (new name: Oncorhynchus mykiss) | EPA OPPTS 797.1600 (Fish Early Life Stage Toxicity Test) |
| octamethylcyclotetrasiloxane 556-67-2 | LC50 | Toxicity > Water solubility | 96 h | Oncorhynchus mykiss | EPA OTS 797.1400 (Fish Acute Toxicity Test) |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Hydrocarbons, C15-C20, n-alkanes, isoalkanes, cyclics, < 0.03% aromatics 1335203-17-2 | LL50 | > 3.193 mg/l | 48 h | Acartia tonsa | other guideline: |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| N,N-Dimethyl-3-(trimethoxysilyl)propylamine 2530-86-1 | EC50 | > 100,1 mg/l | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Titanium dioxide 13463-67-7 | EC50 | Toxicity > Water solubility | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| titanium dioxide 1317-70-0 | EC50 | > 1.000 mg/l | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Ti-oxide rutile 1317-80-2 | LC50 | Toxicity > Water solubility | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Decamethylcyclopentasiloxane 541-02-6 | EC50 | Toxicity > Water solubility | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Dioctyltin dilaurate 3648-18-8 | EC50 | Toxicity > Water solubility | 48 h | Daphnia magna | OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) |
Toxicity
Toxicity (Daphnia):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| octamethylcyclotetrasiloxane 556-67-2 | EC50 | Toxicity > Water solubility | 48 h | Daphnia magna | EPA OTS 797.1300 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids) |
12.1 Toxicity
# Chronic toxicity to aquatic invertebrates
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Titanium dioxide 13463-67-7 | NOEC | Toxicity > Water solubility | 21 d | Daphnia magna | OECD Guideline 202 (Daphnia sp. Chronic Immobilisation Test) |
12.1 Toxicity
Chronic toxicity to aquatic invertebrates: Decamethylcyclopentasiloxane 541-02-6, NOEC, Toxicity > Water solubility, 21 d, Daphnia magna, OECD 211 (Daphnia magna, Reproduction Test)
12.1 Toxicity
Chronic toxicity to aquatic invertebrates
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Dodecamethylcyclohexasiloxane 540-97-6 | NOEC | Toxicity > Water solubility | 21 d | Daphnia magna | OECD 211 (Daphnia magna, Reproduction Test) |
12.1 Toxicity
Chronic toxicity to aquatic invertebrates: octamethylcyclotetrasiloxane 556-67-2, NOEC 7.9 μg/l, 21 d, Daphnia magna, EPA OTS 797.1330 (Daphnid Chronic Toxicity Test)
12.1 Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Hydrocarbons, C15-C20, n-alkanes, isoalkanes, cyclics, < 0.03% aromatics 1335203-17-2 | EL50 | > 10.000 mg/l | 72 h | Skeletonema costatum | ISO 10253 (Water quality) |
Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| N,N-Dimethyl-3-(trimethoxysilyl)propylamine 2530-86-1 | EC50 | > 311 mg/l | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |
| N,N-Dimethyl-3-(trimethoxysilyl)propylamine 2530-86-1 | NOEC | 32,4 mg/l | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |
Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Titanium dioxide 13463-67-7 | EC50 | Toxicity > Water solubility | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |
| Titanium dioxide 13463-67-7 | NOEC | Toxicity > Water solubility | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |
12.1 Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Ti-oxide rutile 1317-80-2 | EC50 | Toxicity > Water solubility | 72 h | Pseudokirchneriella subcapitata | other guideline: |
| Ti-oxide rutile 1317-80-2 | EC10 | Toxicity > Water solubility | 72 h | Pseudokirchneriella subcapitata | other guideline: |
12.1 Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Decamethylcyclopentasiloxane 541-02-6 | NOEC | Toxicity > Water solubility | 96 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | OECD Guideline 201 (Alga, Growth Inhibition Test) |
| Decamethylcyclopentasiloxane 541-02-6 | EC50 | Toxicity > Water solubility | 96 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | OECD Guideline 201 (Alga, Growth Inhibition Test) |
Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Dodecamethylcyclohexasiloxane 540-97-6 | NOEC | Toxicity > Water solubility | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |
| Dodecamethylcyclohexasiloxane 540-97-6 | EC50 | Toxicity > Water solubility | 72 h | Pseudokirchneriella subcapitata | OECD Guideline 201 (Alga, Growth Inhibition Test) |
Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Dioctyltin dilaurate 3648-18-8 | NOEC | Toxicity > Water solubility | 72 h | Desmodesmus subspicatus (reported as Scenedesmus subspicatus) | OECD Guideline 201 (Alga, Growth Inhibition Test) |
Toxicity
Toxicity (Algae):
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| octamethylcyclotetrasiloxane 556-67-2 | EC50 | Toxicity > Water solubility | 96 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | EPA OTS 797.1050 (Algal Toxicity, Tiers I and II) |
| octamethylcyclotetrasiloxane 556-67-2 | EC10 | 0,022 mg/l | 96 h | Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) | EPA OTS 797.1050 (Algal Toxicity, Tiers I and II) |
Toxicity
Toxicity to microorganisms
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Hydrocarbons, C15-C20, n-alkanes, isoalkanes, cyclics, < 0.03% aromatics 1335203-17-2 | EC 50 | > 100 mg/l | 3 h | activated sludge of a predominantly domestic sewage | OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test) |
12.1 Toxicity
Toxicity to microorganisms
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Titanium dioxide 13463-67-7 | EC0 | Toxicity > Water solubility | 24 h | Pseudomonas fluorescens | DIN 38412, part 8 (Pseudomonas Zellvermehrungshemm-Test) |
12.1 Toxicity
Toxicity to microorganisms: EC0 10.000 mg/l, 24 h, not specified.
Toxicity
Toxicity to microorganisms
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Ti-oxide rutile 1317-80-2 | EC0 | 10.000 mg/l | 24 h | | not specified |
12.1 Toxicity
Toxicity to microorganisms
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| Decamethylcyclopentasiloxane 541-02-6 | EC50 | > 2.000 mg/l | 3 h | activated sludge, domestic | EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test) |
Toxicity to microorganisms
Toxicity to microorganisms
| Hazardous substances CAS-No. | Value type | Value | Exposure time | Species | Method |
| octamethylcyclotetrasiloxane 556-67-2 | EC50 | Toxicity > Water solubility | 3 h | activated sludge | ISO 8192 (Test for Inhibition of Oxygen Consumption by Activated Sludge) |
12.2. Persistence and degradability
| Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method |
| Hydrocarbons, C15-C20, n-alkanes, isosalkanes, cyclics, < 0.03% aromatics 1335203-17-2 | readily biodegradable | aerobic | 74 % | 28 d | OECD Guideline 306 (Biodegradability in Seawater) |
12.2. Persistence and degradability
Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method |
N,N-Dimethyl-3-(trimethoxysilyl)propylamine 2530-86-1 | not readily biodegradable. | aerobic | 24 % | 28 d | OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
12.2. Persistence and degradability
| Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method |
| Decamethylcyclopentasiloxane 541-02-6 | not readily biodegradable. | aerobic | 0,14 % | 28 d | OECD Guideline 310 (Ready BiodegradabilityCO2 in Sealed Vessels (Headspace Test) |
12.2. Persistence and degradability
Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method |
Dodecamethylcyclohexasiloxane 540-97-6 | not readily biodegradable. | aerobic | 4,47 % | 28 d | OECD Guideline 310 (Ready BiodegradabilityCO2 in Sealed Vessels (Headspace Test)
12.2. Persistence and degradability
| Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method |
| Dioctyltin dilaurate 3648-18-8 | not readily biodegradable. | aerobic | 1,9 % | 28 day | OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) |
12.2. Persistence and degradability
| Hazardous substances CAS-No. | Result | Test type | Degradability | Exposure time | Method |
| octamethylcyclotetrasiloxane 556-67-2 | not readily biodegradable. | aerobic | 3,7 % | 29 d | OECD Guideline 310 (Ready BiodegradabilityCO2 in Sealed Vessels (Headspace Test) |
12.3. Bioaccumulative potential
| Hazardous substances CAS-No. | Bioconcentration factor (BCF) | Exposure time | Temperature | Species | Method |
| Decamethylcyclopentasiloxane 541-02-6 | 7.060 | 35 d | | Pimephales promelas | OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) |
12.3. Bioaccumulative potential
| Hazardous substances CAS-No. | Bioconcentration factor (BCF) | Exposure time | Temperature | Species | Method |
| Dodecamethylcyclohexasiloxane 540-97-6 | 1.160 | 49 d | | Pimephales promelas | OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) |
12.3. Bioaccumulative potential
| Hazardous substances CAS-No. | Bioconcentration factor (BCF) | Exposure time | Temperature | Species | Method |
| Dioctyltin dilaurate 3648-18-8 | < 100 | 30 day | | Salmo irideus | OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) |
12.3. Bioaccumulative potential
12.3. Bioaccumulative potential
| Hazardous substances CAS-No. | Bioconcentration factor (BCF) | Exposure time | Temperature | Species | Method |
| octamethylcyclotetrasiloxane 556-67-2 | 12.400 | 28 d | | Pimephales promelas | EPA OTS 797.1520 (Fish Bioconcentration Test-Rainbow Trout) |
12.4. Mobility in soil
| Hazardous substances CAS-No. | LogPow | Temperature | Method |
| --- | --- | --- | --- |
| N,N-Dimethyl-3-(trimethoxysilyl)propylamine 2530-86-1 | 0,51 | 25 °C | QSAR (Quantitative Structure Activity Relationship) |
| Decamethylcyclopentasiloxane 541-02-6 | 8,07 | 24,6 °C | other guideline: |
| Dodecamethylcyclohexasiloxane 540-97-6 | 8,87 | 23,6 °C | other guideline: |
| Dioctyltin dilaurate 3648-18-8 | 14,56 | | not specified |
| octamethylcyclotetrasiloxane 556-67-2 | 6,98 | 21,7 °C | other guideline: |
12.5. Results of PBT and vPvB assessment
Hazardous substances CAS-No. | PBT / vPvB
--- | ---
Hydrocarbons, C15-C20, n-alkanes, isoalkanes, cyclics, < 0.03% aromatics 1335203-17-2 | Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria.
N,N-Dimethyl-3-(trimethoxysilyl)propylamine 2530-86-1 | Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria.
Titanium dioxide 13463-67-7 | According to Annex XIII of regulation (EC) 1907/2006 a PBT and vPvB assessment shall not be conducted for inorganic substances.
titanium dioxide 1317-70-0 | According to Annex XIII of regulation (EC) 1907/2006 a PBT and vPvB assessment shall not be conducted for inorganic substances.
Ti-oxide rutile 1317-80-2 | According to Annex XIII of regulation (EC) 1907/2006 a PBT and vPvB assessment shall not be conducted for inorganic substances.
Decamethylcyclopentasiloxane 541-02-6 | Fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria.
Dodecamethylcyclohexasiloxane 540-97-6 | Fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria.
Dioctyltin dilaurate 3648-18-8 | Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria.
octamethylcyclotetrasiloxane 556-67-2 | Fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria.
The PBT and vPvB assessment results indicate that Decamethylcyclopentasiloxane, Dodecamethylcyclohexasiloxane, and octamethylcyclotetrasiloxane fulfill the PBT/vPvB criteria, while others do not or are exempt as inorganic substances.
12.6. Endocrine disrupting properties
not applicable
12.7. Other adverse effects
No data available.