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Safety Data Sheet EN

Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis
Product Code
109271

Regulatory Identifiers

CAS Number
N/A
REACH No.
This product is a mixture. REACH Registration Number see section 3.

Identified Uses

In vitro diagnostic reagent, Reagent for analysis

Manufacturers & Suppliers

M

Merck KGaA

manufacturer

64271 Darmstadt, Germany

+49 6151 72-0

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Flam. Liq. Cat. 2 H225
Acute Tox. Cat. 4 H302
Acute Tox. Cat. 4 H332
Acute Tox. Cat. 4 H312
STOT SE Cat. 1 H370

GHS Pictograms

GHS02 - Flammable

GHS02

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

Hazard Statements

H225 Highly flammable liquid and vapour.
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
H370 Causes damage to organs (Eyes).

Precautionary Statements

P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P403 + P235 Store in a well-ventilated place. Keep cool.
IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture

Ethanolic-methanolic dye solution.

Chemical Name CAS Number Concentration Hazardous
methanol 67-56-1 10 - 20% Yes
ethylene glycol 107-21-1 1 - 10% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Move to fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

Skin contact

Wash off with plenty of water. Remove contaminated clothing. Consult a physician.

Eye contact

Rinse out with plenty of water with the eyelid held wide open. Call in ophthalmologist if necessary.

Ingestion

Move to fresh air. Make victim drink ethanol (e.g. 1 drinking glass of a 40% alcoholic beverage). Call a doctor immediately (mention methanol ingestion). Only in exceptional cases, if no medical care is available within one hour, induce vomiting (only in fully conscious persons) and make victim drink ethanol again (approx. 0.3 ml of a 40% alcoholic beverage/kg body weight/hour).

Immediate Medical Attention

No information available.

Medical Treatment

No information available.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Carbon dioxide (CO2), Foam, Dry powder

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Combustible. Vapours are heavier than air and may spread along floors. Forms explosive mixtures with air at ambient temperatures. Pay attention to flashback. Development of hazardous combustion gases or vapours possible in the event of fire.

Instructions

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapours/mists with a water spray jet.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental

Do not let product enter drains. Risk of explosion.

Cleanup methods

Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No. 101595).

Materials: liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No. 101595)

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. Observe label precautions.

Storage

Keep container tightly closed in a dry and well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Fire prevention

Keep away from open flames, hot surfaces and sources of ignition.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Technical measures and appropriate working operations should be given priority over the use of personal protective equipment. See section 7.1.

Hands

full contact: Glove material: butyl-rubber Glove thickness: 0,7 mm Break through time: - 480 min splash contact: Glove material: Viton (R) Glove thickness: 0,70 mm Break through time: - 120 min The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374, for example KCL 898 Butoject (full contact), KCL 890 Vitoject (splash contact). The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types. This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g., KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Eyes

Safety glasses

Respiratory

required when vapours/aerosols are generated. Recommended Filter type: filter ABEK The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Skin/Body

Flame retardant antistatic protective clothing

Environmental

Do not let product enter drains. Risk of explosion.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
---
Colour
greenish-blue
Colour Intensity
---
Form
liquid
Odor
of ethanol
Odor Threshold
No information available.
Ph
5,0 - 5,5 at 20 C
Melting Point
No information available.
Boiling Point
No information available.
Flash Point
17 C
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No information available.
Vapor Pressure
No information available.
Vapor Density
---
Relative Density
0,82 g/cm at 20 C
Bulk Density
---
Density
---
Flammability
No information available.
Upper Explosive Limit
No information available.
Lower Explosive Limit
No information available.
Explosive Limits
---
Auto Ignition Temperature
No information available.
Decomposition Temperature
No information available.
Solubility
---
Partition Coefficient
No information available.
Solubility In Water
soluble
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
No information available.
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

Vapours may form explosive mixture with air.

Hazardous reactions

Risk of explosion with: chromium(VI) oxide, hydrogen peroxide, uranium hexafluoride, nitrogen dioxide, Nitric acid, Oxides of phosphorus, permanganic acid, perchloric acid, perchlorates, Fluorine, Ethylene oxide, chromyl chloride, halogen-halogen compounds, Strong oxidizing agents, alkali oxides, Alkaline earth metals, Alkali metals, potassium permanganate, sulphuric acid. Risk of ignition or formation of inflammable gases or vapours with: chromium(VI) oxide, hydrogen peroxide, uranium hexafluoride, nitrogen dioxide, Nitric acid, Oxides of phosphorus, permanganic acid, perchloric acid, perchlorates, Fluorine, Ethylene oxide, chromyl chloride, halogen-halogen compounds, Strong oxidizing agents, alkali oxides, Alkaline earth metals, Alkali metals, potassium permanganate, sulphuric acid.

Avoid

Warming. A range from approx. 15 Kelvin below the flash point is to be rated as critical.

Incompatible

chromium(VI) oxide, hydrogen peroxide, uranium hexafluoride, nitrogen dioxide, Nitric acid, Oxides of phosphorus, permanganic acid, perchloric acid, perchlorates, Fluorine, Ethylene oxide, chromyl chloride, halogen-halogen compounds, Strong oxidizing agents, alkali oxides, Alkaline earth metals, Alkali metals, potassium permanganate, sulphuric acid

Decomposition

no information available

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

No information available.

12.2 Persistence and degradability

No information available.

12.3 Bioaccumulative potential

No information available.

12.4 Mobility in soil

No information available.

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.

12.1 Toxicity

Components: methanol: Toxicity to fish: LC50 Lepomis macrochirus (Bluegill sunfish): 15.400 mg/l; 96 h (in soft water) (ECOTOX Database). Toxicity to daphnia and other aquatic invertebrates: EC5 E.sulcatum: > 10.000 mg/l; 72 h (Lit.); EC50 Daphnia magna (Water flea): > 10.000 mg/l; 48 h (IUCLID). Toxicity to algae: EC50 Pseudokirchneriella subcapitata (green algae): ca. 22.000 mg/l; 96 h (External MSDS); IC5 Scenedesmus quadricauda (Green algae): 8.000 mg/l; 8 d (IUCLID). Toxicity to bacteria: EC5 Pseudomonas fluorescens: 6.600 mg/l; 16 h (IUCLID). Toxicity to fish (Chronic toxicity): NOEC Oryzias latipes (Orange-red killifish): 7.900 mg/l; 200 h (External MSDS). ethylene glycol: Toxicity to fish: LC50 Oncorhynchus mykiss (rainbow trout): > 18.500 mg/l; 96 h (External MSDS). Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea): 74.000 mg/l; 24 h (Lit.); EC5 E.sulcatum: > 10.000 mg/l; 72 h (Lit.). Toxicity to algae: IC5 Scenedesmus quadricauda (Green algae): > 10.000 mg/l; 7 d (Lit.). Toxicity to bacteria: microtox test EC50 Photobacterium phosphoreum: 112.000 mg/l; 5 min; EC5 Pseudomonas putida: > 10.000 mg/l; 16 h (Lit.); EC50 Pseudomonas putida: > 10.000 mg/l; 16 h (Lit.).

12.2 Persistence and degradability

methanol: Biodegradability: 99 %; 30 d, OECD Test Guideline 301D, Readily biodegradable. Biochemical Oxygen Demand (BOD): 600 - 1.120 mg/g (5 d) (IUCLID). Chemical Oxygen Demand (COD): 1.420 mg/g (IUCLID). Theoretical oxygen demand (ThOD): 1.500 mg/g (Lit.). Ratio BOD/ThBOD: BOD5 76%, Closed Bottle test. Stability in water: 2,2 yr, reaction with hydroxyl radicals (IUCLID). ethylene glycol: Biodegradability: 83 - 96 %; 14 d, OECD Test Guideline 301C, Readily biodegradable. Biochemical Oxygen Demand (BOD): 780 mg/g (5 d) (IUCLID). Chemical Oxygen Demand (COD): 1.190 mg/g (IUCLID). Theoretical oxygen demand (ThOD): 1.290 mg/g (IUCLID). Ratio BOD/ThBOD: BOD5 60% (IUCLID).

12.5 Results of PBT and vPvB assessment

Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.

12.7 Other adverse effects

Discharge into the environment must be avoided.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
UN 1992
Shipping Name
FLAMMABLE LIQUID, TOXIC, N.O.S. (CONT. METHANOL, ETHANOL)
Transport Class
3
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

Regulatory information regarding Seveso III, occupational restrictions, and chemical regulations.

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis?

The signal word is danger.

What is the physical form of Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis?

Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis is a liquid with greenish-blue color. It has of ethanol odor.

What is Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis used for?

In vitro diagnostic reagent, Reagent for analysis

What are the hazard statements for Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis?

This substance has 3 hazard statements:

  • H225: Highly flammable liquid and vapour.
  • H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled
  • H370: Causes damage to organs (Eyes).

What is the melting point of Papanicolaou's solution 3a polychromatic solution EA 31 for cytological cancer and cycle diagnosis?

The melting point is No information available. and the boiling point is No information available..