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Safety Data Sheet EN

Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis
Product Code
109253

Regulatory Identifiers

CAS Number
N/A
REACH No.
This product is a mixture. REACH Registration Number see section 3.

Identified Uses

In vitro diagnostic reagent, Reagent for analysis For additional information on uses please refer to the Merck Chemicals portal (www.merckgroup.com).

Manufacturers & Suppliers

M

Merck KGaA

manufacturer

64271 Darmstadt, Germany

+49 6151 72-0

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Eye Dam. Cat. 1 H318

GHS Pictograms

GHS05 - Corrosive

GHS05

Hazard Statements

H318 Causes serious eye damage.

Precautionary Statements

P280 Wear eye protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture

Mixture of inorganic and organic compounds

Chemical Name CAS Number Concentration Hazardous
ethylene glycol 107-21-1 1 - 10% Yes
ethanol 64-17-5 3 - 10% Yes
aluminium sulfate 10043-01-3 3 - 5% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

fresh air.

Skin contact

Take off immediately all contaminated clothing. Rinse skin with water/ shower.

Eye contact

rinse out with plenty of water. Immediately call in ophthalmologist.

Symptoms: Risk of serious damage to eyes.

Ingestion

immediately make victim drink water (two glasses at most). Consult a physician.

Immediate Medical Attention

Immediately call in ophthalmologist (after eye contact). Consult a physician (after swallowing).

Medical Treatment

No information available.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Not combustible. Ambient fire may liberate hazardous vapours.

Instructions

Suppress (knock down) gases/vapours/mists with a water spray jet.

Firefighter Protection

In the event of fire, wear self-contained breathing apparatus.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental

Do not let product enter drains.

Cleanup methods

Take up with liquid-absorbent and neutralising material. Clean up affected area.

Materials: liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No. 101595)

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Observe label precautions.

Storage

Tightly closed. Recommended storage temperature see product label.

Hygiene

Change contaminated clothing. Wash hands after working with substance.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Technical measures and appropriate working operations should be given priority over the use of personal protective equipment. See section 7.1.

Hands

For full contact: Glove material: Nitrile rubber, Glove thickness: 0,11 mm, Break through time: - 480 min. For splash contact: Glove material: Nitrile rubber, Glove thickness: 0,11 mm, Break through time: - 480 min. Protective gloves must comply with EC Directive 89/686/EEC and the related standard EN374, for example KCL 741 Dermatril L.

Eyes

Tightly fitting safety goggles

Respiratory

Required when vapours/aerosols are generated. Recommended Filter type: filter ABEK. The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer and properly documented.

Skin/Body

protective clothing

Environmental

Do not let product enter drains.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
---
Colour
reddish-violet
Colour Intensity
---
Form
liquid
Odor
odourless
Odor Threshold
Not applicable
Ph
2,5 - 3,0 at 20 C
Melting Point
No information available.
Boiling Point
ca. 100 C at 1.013 hPa
Flash Point
No information available.
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No information available.
Vapor Pressure
No information available.
Vapor Density
---
Relative Density
No information available.
Bulk Density
---
Density
1,04 g/cm3 at 20 C
Flammability
No information available.
Upper Explosive Limit
No information available.
Lower Explosive Limit
No information available.
Explosive Limits
---
Auto Ignition Temperature
No information available.
Decomposition Temperature
No information available.
Solubility
---
Partition Coefficient
No information available.
Solubility In Water
soluble
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
No information available.
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

See section 10.3

Hazardous reactions

Violent reactions possible with: The generally known reaction partners of water.

Avoid

no information available

Incompatible

no information available

Decomposition

no information available

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

The Safety Data Sheets for catalogue items are available at www.merckgroup.com No information available.

No information available.

12.2 Persistence and degradability

No information available.

12.3 Bioaccumulative potential

No information available.

12.4 Mobility in soil

No information available.

No information available.

12.5 Results of PBT and vPvB assessment

Substance(s) in the mixture do(es) not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII, or a PBT/vPvB assessment was not conducted.

Substance(s) in the mixture do(es) not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII, or a PBT/vPvB assessment was not conducted.

12.1 Toxicity

ethylene glycol: Toxicity to fish LC50 Oncorhynchus mykiss (rainbow trout): > 18.500 mg/l; 96 h. Toxicity to daphnia and other aquatic invertebrates static test Daphnia magna (Water flea): > 100 mg/l; 48 h. Toxicity to algae IC5 Scenedesmus quadricauda (Green algae): > 10.000 mg/l; 7 d. Toxicity to bacteria static test EC5 Pseudomonas putida: > 10.000 mg/l; 16 h. ethanol: Toxicity to fish LC50 Leuciscus idus (Golden orfe): 8.140 mg/l; 48 h. Toxicity to daphnia and other aquatic invertebrates EC5 E.sulcatum: 65 mg/l; 72 h. EC50 Daphnia magna (Water flea): 9.268 - 14.221 mg/l; 48 h. Toxicity to algae IC5 Scenedesmus quadricauda (Green algae): 5.000 mg/l; 7 d. Toxicity to bacteria EC5 Pseudomonas putida: 6.500 mg/l; 16 h. Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity) semi-static test NOEC Daphnia magna (Water flea): 9,6 mg/l; 9 d. aluminium sulfate: Toxicity to fish static test LC50 Pimephales promelas (fathead minnow): 27,9 mg/l; 96 h. Toxicity to daphnia and other aquatic invertebrates semi-static test LC50 Daphnia magna (Water flea): 242 mg/l; 48 h. semi-static test NOEC Daphnia magna (Water flea): 48,4 mg/l; 48 h. Toxicity to algae static test EC50 plankton: 19.091 mg/l; 5 d. static test NOEC plankton: 3.818 mg/l; 5 d. Toxicity to bacteria Respiration inhibition EC50 microorganisms: 0,5 mg/l; 396 d. Respiration inhibition NOEC microorganisms: 0,1 mg/l; 396 d. Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity) Reproduction Test NOEC Daphnia magna (Water flea): 12 mg/l; 28 d.

12.2 Persistence and degradability

ethylene glycol: Biodegradability 100 %; 10 d; aerobic. Biochemical Oxygen Demand (BOD) 780 mg/g (5 d). Chemical Oxygen Demand (COD) 1.190 mg/g. Theoretical oxygen demand (ThOD) 1.290 mg/g. Ratio BOD/ThBOD BOD5 60 %. ethanol: Biodegradability 94 %. Biochemical Oxygen Demand (BOD) 930 - 1.670 mg/g (5 d). Theoretical oxygen demand (ThOD) 2.100 mg/g. Ratio COD/ThBOD 90 %.

12.3 Bioaccumulative potential

ethanol: Partition coefficient: n-octanol/water log Pow: -0,31 (experimental) (Lit.) Bioaccumulation is not expected.

12.4 Mobility in soil

12.5 Results of PBT and vPvB assessment

Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.

12.6 Endocrine disrupting properties

12.7 Other adverse effects

Discharge into the environment must be avoided.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis?

The signal word is danger.

What is the physical form of Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis?

Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis is a liquid with reddish-violet color. It has odourless odor.

What is Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis used for?

In vitro diagnostic reagent, Reagent for analysis For additional information on uses please refer to the Merck Chemicals portal (www.merckgroup.com).

What are the hazard statements for Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis?

This substance has 1 hazard statement:

  • H318: Causes serious eye damage.

What is the melting point of Papanicolaou's solution 1a Harris' hematoxylin solution for cytological cancer and cycle diagnosis?

The melting point is No information available. and the boiling point is ca. 100 C at 1.013 hPa.