Identification
Product identifiers, regulatory numbers, and supplier information
Product Information
- Product Name
- Tris(hydroxymethyl)aminomethane (Trometamol) suitable for use as excipient EMPROVE® exp Ph Eur,BP,JPC,USP
- Product Code
- 108386
Regulatory Identifiers
- CAS Number
- 77-86-1 Check regulations →
- REACH No.
- 01-2119957659-16-XXXX
Identified Uses
Pharmaceutical production, Cosmetic raw material
Manufacturers & Suppliers
Merck KGaA
manufacturer
64271 Darmstadt, Germany
+49 6151 72-0
Hazard Identification
GHS classification, signal word, pictograms, and hazard statements
Hazard Classifications
GHS Pictograms
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Composition / Information on Ingredients
Chemical components, concentration ranges, and hazardous substance identification
Formula H₂NC(CH₃OH)₃ C₄H₁₁NO₃ (Hill) EC-No. 201-064-4 Molar mass 121,14 g/mol Remarks No disclosure requirement according to Regulation (EC) No. 1907/2006.
| Chemical Name | CAS Number | Concentration | Hazardous |
|---|---|---|---|
| Tris(hydroxymethyl)aminomethane (Trometamol) EC: 201-064-4 | --- | --- | No |
First Aid Measures
Emergency procedures for chemical exposure incidents
fresh air.
Symptoms: Mucosal irritations, coughing, and dyspnoea
Take off immediately all contaminated clothing. Rinse skin with water/shower.
Symptoms: irritations
rinse out with plenty of water.
Symptoms: irritations
make victim drink water (two glasses at most). Consult doctor if feeling unwell.
Symptoms: Nausea, Vomiting, Convulsions, Diarrhoea
Firefighting Measures
Extinguishing media, specific hazards, and firefighter protection
Water, Foam, Carbon dioxide (CO2), Dry powder
For this substance/mixture no limitations of extinguishing agents are given.
Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.
Suppress (knock down) gases/vapours/mists with a water spray jet.
Firefighter Protection
In the event of fire, wear self-contained breathing apparatus.
Accidental Release Measures
Spill cleanup procedures, containment, and environmental protection
Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert.
Do not let product enter drains.
Take up dry.
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Similar products with comparable safety profiles
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Handling and Storage
Safe handling precautions, storage conditions, and workplace requirements
Observe label precautions.
Tightly closed. Dry.
Change contaminated clothing. Wash hands after working with substance.
Exposure Controls / PPE
Occupational exposure limits, engineering controls, and protective equipment
Technical measures and appropriate working operations should be given priority over the use of personal protective equipment. See section 7.1.
full contact: Glove material: Nitrile rubber, Glove thickness: 0,11 mm, Break through time: > 480 min; splash contact: Glove material: Nitrile rubber, Glove thickness: 0,11 mm, Break through time: > 480 min. The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact), KCL 741 Dermatril® L (splash contact). The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types. This recommendation applies only to the product stated in the safety data sheet supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Safety glasses
required when dusts are generated. Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances. The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Protective clothing needs to be selected specifically for the workplace, depending on concentrations and quantities of the hazardous substances handled.
Do not let product enter drains.
Physical and Chemical Properties
Appearance, physical state, melting point, boiling point, and material characteristics
Stability and Reactivity
Chemical stability, hazardous reactions, and incompatible materials
The product is chemically stable under standard ambient conditions (room temperature).
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Violent reactions possible with: Oxidizing agents, Bases. Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitosamines!
no information available
Oxidizing agents, Bases, nitrites, nitrates, nitrous acid
nitosamines
Ecological Information
Environmental toxicity, biodegradation, and bioaccumulation data
The data for this section has not been processed yet.
Disposal Considerations
Waste treatment methods, disposal recommendations, and waste codes
The data for this section has not been processed yet.
Transport Information
UN numbers, shipping names, transport classes, and regulatory requirements
Regulatory Information
Chemical regulations, safety assessments, and compliance status
The data for this section has not been processed yet.
Frequently Asked Questions
Common questions about safety, handling, and properties
What is the hazard signal word for Tris(hydroxymethyl)aminomethane (Trometamol) suitable for use as excipient EMPROVE® exp Ph Eur,BP,JPC,USP?
The signal word is no signal word.
What is the physical form of Tris(hydroxymethyl)aminomethane (Trometamol) suitable for use as excipient EMPROVE® exp Ph Eur,BP,JPC,USP?
Tris(hydroxymethyl)aminomethane (Trometamol) suitable for use as excipient EMPROVE® exp Ph Eur,BP,JPC,USP is a solid with white color. It has odourless odor.
What is Tris(hydroxymethyl)aminomethane (Trometamol) suitable for use as excipient EMPROVE® exp Ph Eur,BP,JPC,USP used for?
Pharmaceutical production, Cosmetic raw material
What is the melting point of Tris(hydroxymethyl)aminomethane (Trometamol) suitable for use as excipient EMPROVE® exp Ph Eur,BP,JPC,USP?
The melting point is 168 - 172 °C and the boiling point is 219 - 220 °C.