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Safety Data Sheet EN

Clozapine 1.0 mg/ml in Acetonitrile

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Clozapine 1.0 mg/ml in Acetonitrile
Product Code
LGCAMP0480.00-11

Regulatory Identifiers

CAS Number
N/A

Identified Uses

This product is for research and development only

Uses advised against

Not to be used for human or animal consumption

Manufacturers & Suppliers

VHG LGC Standards logo

VHG LGC Standards

manufacturer

276 Abby Road, Manchester, NH 03103, UNITED STATES OF AMERICA

+1 (603) 622-7660

http://lgcstandards.com

Emergency Contacts

CHEMTREC

1-800-424-9300

CHEMTREC

+1 703-741-5970

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Acute Tox. Cat. 4
Acute Tox. Cat. 4
Acute Tox. Cat. 4
Eye Irrit. Cat. 2
Repr. Cat. 2
Lact.
Flam. Liq. Cat. 2

GHS Pictograms

GHS02 - Flammable

GHS02

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

Hazard Statements

H225 Highly flammable liquid and vapor
H302 Harmful if swallowed
H312 Harmful in contact with skin
H319 Causes serious eye irritation
H332 Harmful if inhaled
H361 Suspected of damaging fertility or the unborn child
H362 May cause harm to breast-fed children

Precautionary Statements

P201 Obtain special instructions before use
P202 Do not handle until all safety precautions have been read and understood
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking
P233 Keep container tightly closed
P240 Ground and bond container and receiving equipment
P242 Use only non-sparking tools
P243 Take action to prevent static discharges
P260 Do not breathe dusts or mists
P263 Avoid contact during pregnancy and while nursing
P264 Wash face, hands and any exposed skin thoroughly after handling
P270 Do not eat, drink or smoke when using this product
P271 Use only outdoors or in a well-ventilated area
P280 Wear protective gloves/clothing and eye/face protection
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower
P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P308 + P313 IF exposed or concerned: Get medical advice/attention
P312 Call a POISON CENTER or doctor if you feel unwell
P330 Rinse mouth
P337 + P313 If eye irritation persists: Get medical advice/attention
P363 Wash contaminated clothing before reuse
P370 + P378 In case of fire: Use CO2, dry chemical, or foam to extinguish
P403 + P235 Store in a well-ventilated place. Keep cool
P405 Store locked up
P501 Dispose of contents/container to an approved waste disposal plant

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture

Mixture of organic compounds.

Chemical Name CAS Number Concentration Hazardous
Acetonitrile 75-05-8 80 - 100% No
Clozapine 5786-21-0 0.1 - 1% No
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Remove to fresh air. If symptoms persist, call a physician. If breathing has stopped, give artificial respiration. Get medical attention immediately.

Symptoms: Coughing and/ or wheezing. Difficulty in breathing.

Skin contact

Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. If symptoms persist, call a physician.

Symptoms: Burning sensation.

Eye contact

Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Keep eye wide open while rinsing. Do not rub affected area. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical attention if irritation develops and persists.

Symptoms: Redness and tearing of the eyes.

Ingestion

Do NOT induce vomiting. Rinse mouth. Never give anything by mouth to an unconscious person. Get medical attention.

Immediate Medical Attention

Get medical attention immediately (inhalation). Get medical attention if irritation develops and persists (eye contact). Get medical attention (ingestion).

Medical Treatment

Treat symptomatically.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Dry chemical. Carbon dioxide (CO2). Water spray. Alcohol resistant foam. CAUTION: Use of water spray when fighting fire may be inefficient.

Unsuitable media

Do not scatter spilled material with high pressure water streams.

Specific hazards

Risk of ignition. Keep product and empty container away from heat and sources of ignition.

Instructions

In the event of fire, cool tanks with water spray.

Firefighter Protection

Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. Use personal protection equipment.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Pay attention to flashback. Do not touch or walk through spilled material.

Environmental

Keep out of drains, sewers, ditches and waterways.

Cleanup methods

Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.

Materials: inert absorbent material

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Use personal protection equipment. Avoid breathing vapors or mists. Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this product. Remove contaminated clothing and shoes. In case of insufficient ventilation, wear suitable respiratory equipment.

Storage

Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat, sparks, flame and other sources of ignition. Keep in properly labeled containers. Do not store near combustible materials. Keep in an area equipped with sprinklers.

Hygiene

Handle in accordance with good industrial hygiene and safety practice. Do not eat, drink or smoke when using this product. Remove contaminated clothing and shoes.

Fire prevention

Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Use grounding and bonding connection when transferring this material to prevent static discharge, fire or explosion. Use spark-proof tools and explosion-proof equipment. Keep in an area equipped with sprinklers.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Showers, Eyewash stations, Ventilation systems.

Hands

Wear protective butyl rubber gloves. The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374. Wear suitable gloves. Impervious gloves.

Eyes

Avoid contact with eyes. Wear safety glasses with side shields (or goggles). Tight sealing safety goggles.

Respiratory

No protective equipment is needed under normal use conditions. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required.

Skin/Body

Wear suitable protective clothing. Long sleeved clothing. Chemical resistant apron. Antistatic boots.

Environmental

Do not allow into any sewer, on the ground or into any body of water.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Physical State
Liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
Liquid
Colour
colorless
Colour Intensity
---
Form
---
Odor
Aromatic
Odor Threshold
No information available
Ph
No data available
Melting Point
-45.72 °C / -50.3 °F
Boiling Point
81.61 °C / 178.9 °F
Flash Point
2 °C / 35.6 °F
Freezing Point
---
Softening Point
No information available
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
No data available
Vapor Pressure
94.51 - 98.64 hPa @ 20°C
Vapor Density
---
Relative Density
0.7857
Bulk Density
No information available
Density
No information available
Flammability
No data available
Upper Explosive Limit
17 Vol%
Lower Explosive Limit
3 Vol% - 50 g/m³
Explosive Limits
---
Auto Ignition Temperature
524 °C / 975.2 °F
Decomposition Temperature
---
Solubility
---
Partition Coefficient
-0.34
Solubility In Water
No data available
Solubility In Fat
---
Molecular Weight
No information available
Voc Content
No information available
Metal Corrosion
---
Dynamic Viscosity
0.35 mPa s @ 25°C
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

No information available.

Hazardous reactions

None under normal processing.

Avoid

Heat, flames and sparks. Excessive heat.

Incompatible

None known based on information supplied.

Decomposition

None known based on information supplied.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

Acetonitrile 75-05-8: LC50: 1600 - 1690mg/L (96h, Pimephales promelas) LC50: ≈1000mg/L (96h, Pimephales promelas) LC50: ≈1850mg/L (96h, Lepomis macrochirus) LC50: ≈1650mg/L (96h, Poecilia reticulata) EC50: 3,600 mg/l (48h, daphnia)

12.2 Persistence and degradability

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

No data available

12.6 Endocrine disrupting properties

No data available

12.7 Other adverse effects

No data available

12.3 Bioaccumulative potential

Partition coefficient: -0.34

12.1 Toxicity

No data available.

12.2 Persistence and degradability

No data available.

12.3 Bioaccumulative potential

Partition coefficient: 3.23

12.4 Mobility in soil

No data available.

12.5 Results of PBT and vPvB assessment

No data available.

12.6 Endocrine disrupting properties

No data available.

12.7 Other adverse effects

No data available.

Other adverse effects

No information available.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Disposal

Should not be released into the environment. Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
UN1648
Shipping Name
Acetonitrile mixture
Transport Class
3
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

LGC has not confirmed that the chemical substances in this product are on the TSCA Inventory, and LGC is distributing this product solely for use either in applications statutorily exempt from TSCA and regulated under other laws (e.g., FFDCA, FIFRA) or in research and development activities in accordance with the TSCA Inventory R&D exemption provided at 40 CFR 720.36. It is the end-user's responsibility to understand and follow the requirements that apply to its use of this product.

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Clozapine 1.0 mg/ml in Acetonitrile?

The signal word is danger.

What is the physical form of Clozapine 1.0 mg/ml in Acetonitrile?

Clozapine 1.0 mg/ml in Acetonitrile is a liquid appearing as liquid with colorless color. It has aromatic odor.

What is Clozapine 1.0 mg/ml in Acetonitrile used for?

This product is for research and development only

What are the hazard statements for Clozapine 1.0 mg/ml in Acetonitrile?

This substance has 7 hazard statements:

  • H225: Highly flammable liquid and vapor
  • H302: Harmful if swallowed
  • H312: Harmful in contact with skin
  • H319: Causes serious eye irritation
  • H332: Harmful if inhaled
  • H361: Suspected of damaging fertility or the unborn child
  • H362: May cause harm to breast-fed children

What is the melting point of Clozapine 1.0 mg/ml in Acetonitrile?

The melting point is -45.72 °C / -50.3 °F and the boiling point is 81.61 °C / 178.9 °F.