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Safety Data Sheet EN

Bortezomib

CAS 179324-69-7

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Bortezomib
Product Code
5.04314, 504314
Chemical Name
Bortezomib

Regulatory Identifiers

CAS Number
179324-69-7 Check regulations →

Identified Uses

Biochemical research/analysis

Manufacturers & Suppliers

S

Sigma-Aldrich Chemie GmbH

national supplier

Eschenstrasse 5, D-82024 TAUFKIRCHEN

+49 (0)89 6513-1130

Emergency Contacts

CHEMTREC Deutschland

0800 181 7059

CHEMTREC weltweit

+49 (0)696 43508409

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified warning

Hazard Classifications

Skin Irrit. Cat. 2 H315
Eye Irrit. Cat. 2 H319
Repr. Cat. 2 H361fd
STOT RE Cat. 2 H373

GHS Pictograms

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

Hazard Statements

H315 Causes skin irritation.
H319 Causes serious eye irritation.
H361fd Suspected of damaging fertility. Suspected of damaging the unborn child.
H373 May cause damage to organs (Gastro-intestinal system, Nervous system, Blood, Liver, Kidney) through prolonged or repeated exposure.

Precautionary Statements

P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust.
P264 Wash skin thoroughly after handling.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
PS-341 179324-69-7 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

After inhalation: fresh air. Call in physician.

Skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

Eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

Ingestion

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.

Instructions

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental

Do not let product enter drains.

Cleanup methods

Take up dry. Clean up affected area.

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Work under hood. Do not inhale substance/mixture.

Storage

Tightly closed. Dry.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Full contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: KCL 741 Dermatril® L. Splash contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: KCL 741 Dermatril® L. This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Eyes

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Respiratory

required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3. The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Skin/Body

protective clothing

Environmental

Do not let product enter drains.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
solid
Physical State Data
solid
State Under Standard Conditions
---
Appearance
---
Colour
off-whiteoff-white
Colour Intensity
---
Form
---
Odor
No data available
Odor Threshold
---
Ph
No data available
Melting Point
No data available
Boiling Point
No data available
Flash Point
Not applicable
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
---
Vapor Pressure
No data available
Vapor Density
---
Relative Density
No data available
Bulk Density
---
Density
No data available
Flammability
---
Upper Explosive Limit
No data available
Lower Explosive Limit
No data available
Explosive Limits
---
Auto Ignition Temperature
No data available
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
No data available
Solubility In Water
No data available
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
No data available
Kinematic Viscosity
No data available
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Hazardous reactions

No data available

Avoid

no information available

Incompatible

Strong oxidizing agents

Decomposition

In the event of fire: see section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

No data available

12.2 Persistence and degradability

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

The substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Endocrine disrupting properties

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

No data available

No data available

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

No data available

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.

Chemical Safety Assessment Not performed
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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Bortezomib?

The signal word is warning.

What is the physical form of Bortezomib?

Bortezomib is a solid with off-whiteoff-white color. It has no data available odor.

What is Bortezomib used for?

Biochemical research/analysis

What are the hazard statements for Bortezomib?

This substance has 4 hazard statements:

  • H315: Causes skin irritation.
  • H319: Causes serious eye irritation.
  • H361fd: Suspected of damaging fertility. Suspected of damaging the unborn child.
  • H373: May cause damage to organs (Gastro-intestinal system, Nervous system, Blood, Liver, Kidney) through prolonged or repeated exposure.

What is the melting point of Bortezomib?

The melting point is No data available and the boiling point is No data available.