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Safety Data Sheet EN

Acetonitrile

CAS 75-05-8

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Acetonitrile
Product Code
271004

Regulatory Identifiers

CAS Number
75-05-8 Check regulations →
REACH No.
01-2119471307-38-XXXX

Identified Uses

Laboratory chemicals, Manufacture of substances

Manufacturers & Suppliers

S

Sigma-Aldrich Chemie GmbH

manufacturer

Eschenstrasse 5, D-82024 TAUFKIRCHEN

+49 (0)89 6513-1130

Emergency Contacts

CHEMTREC Deutschland

0800 181 7059

CHEMTREC weltweit

+49 (0)696 43508409

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Flam. Liq. Cat. 2 H225
Acute Tox. Cat. 4 H302
Acute Tox. Cat. 4 H332
Acute Tox. Cat. 4 H312
Eye Irrit. Cat. 2 H319

GHS Pictograms

GHS02 - Flammable

GHS02

GHS07 - Health hazard

GHS07

Hazard Statements

H225 Highly flammable liquid and vapor.
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled.
H319 Causes serious eye irritation.

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor if you feel unwell.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Acetonitrile EC: 200-835-2 75-05-8 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Fresh air. If breathing stops: mouth-to-mouth breathing or artificial respiration. Oxygen if necessary. Immediately call in physician.

Skin contact

Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

Eye contact

Rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

Ingestion

Immediately make victim drink water (two glasses at most). Consult a physician.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water, Foam, Carbon dioxide (CO2), Dry powder

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Combustible. Fire may cause evolution of: nitrogen oxides, Hydrogen cyanide (hydrocyanic acid). Pay attention to flashback. Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Instructions

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental

Do not let product enter drains. Risk of explosion.

Cleanup methods

Take up with liquid-absorbent material (e.g. Chemizorb®). Clean up affected area.

Materials: liquid-absorbent material (e.g. Chemizorb®)

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Filled under nitrogen. Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Storage

Keep container tightly closed in a dry and well-ventilated place.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Fire prevention

Keep away from open flames, hot surfaces and sources of ignition.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Full contact: Material: butyl-rubber, Minimum layer thickness: 0,7 mm, Break through time: 480 min, Material tested: Butoject® (KCL 898). Splash contact: Material: Chloroprene, Minimum layer thickness: 0,65 mm, Break through time: 10 min, Material tested: KCL 720 Camapren®. This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Eyes

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Respiratory

Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds. The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Skin/Body

Flame retardant antistatic protective clothing.

Environmental

Do not let product enter drains. Risk of explosion.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
clear, liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
---
Colour
colorless
Colour Intensity
---
Form
---
Odor
ether-like
Odor Threshold
---
Ph
No data available
Melting Point
-48 °C
Boiling Point
81 - 82 °C
Flash Point
2,0 °C - closed cup
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
---
Vapor Pressure
98,64 hPa at 20 °C
Vapor Density
---
Relative Density
No data available
Bulk Density
---
Density
0,786 g/mL at 25 °C
Flammability
No data available
Upper Explosive Limit
16 %(V)
Lower Explosive Limit
4,4 %(V)
Explosive Limits
---
Auto Ignition Temperature
No data available
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
log Pow: -0,54 at 25 °C - Bioaccumulation is not expected.
Solubility In Water
1.000 g/l at 25 °C completely soluble
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
0,350 Pas at 20,00 °C
Kinematic Viscosity
No data available
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

Vapors may form explosive mixture with air.

Hazardous reactions

Violent reactions possible with: Strong bases, strong reducing agents. Risk of explosion with: nitrates, perchlorates, perchloric acid, conc. sulfuric acid, with Heat. Risk of ignition or formation of inflammable gases or vapours with: Oxidizing agents, Nitric acid, nitrogen dioxide, with Catalyst. Generates dangerous gases or fumes in contact with: Acids

Avoid

Heat, Catalyst

Incompatible

Strong bases, strong reducing agents, nitrates, perchlorates, perchloric acid, conc. sulfuric acid, Oxidizing agents, Nitric acid, nitrogen dioxide, Acids

Decomposition

In the event of fire: see section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1 Toxicity

Toxicity to fish flow-through test LC50 - Pimephales promelas (fathead minnow) - 1.640 mg/l - 96 h Remarks: (ECHA) Toxicity to algae static test NOEC - Phaeodactylum tricornutum - 400 mg/l - 72 h (ISO 10253) static test ErC50 - Phaeodactylum tricornutum - 9.696 mg/l - 72 h Sigma-Aldrich 271004 The life science business of Merck operates as MilliporeSigma in the US and Canada Page 10 of 14 (ISO 10253) Toxicity to bacteria Toxicity to flow-through test NOEC - Oryzias latipes - 102 mg/l - 21 d fish (Chronic toxicity) (OECD Test Guideline 204)

12.2 Persistence and degradability

Biodegradability Result: 70 % - Readily biodegradable. (OECD Test Guideline 310)

12.3 Bioaccumulative potential

12.3 Bioaccumulative potential

No bioaccumulation is to be expected (log Pow <= 4).

No bioaccumulation is to be expected (log Pow <= 4).

12.4 Mobility in soil

Not expected to adsorb on soil.

12.5 Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

The substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Endocrine disrupting properties

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

Avoid release to the environment. Stability in water DT50 - > 9.999 d pH 7 at 25 °C Remarks: (calculated) Hydrolyzes slowly.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

No data available

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
1648
Shipping Name
ACETONITRILE
Transport Class
3
Packing Group
II
ADR

Tunnel restriction code : (D/E)

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Acetonitrile?

The signal word is danger.

What is the physical form of Acetonitrile?

Acetonitrile is a clear, liquid with colorless color. It has ether-like odor.

What is Acetonitrile used for?

Laboratory chemicals, Manufacture of substances

What are the hazard statements for Acetonitrile?

This substance has 3 hazard statements:

  • H225: Highly flammable liquid and vapor.
  • H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.
  • H319: Causes serious eye irritation.

What is the melting point of Acetonitrile?

The melting point is -48 °C and the boiling point is 81 - 82 °C.