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Safety Data Sheet EN

Acetonitrile

CAS 75-05-8
EC 200-835-2

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Acetonitrile
Product Code
448390000; 448391000
Chemical Name
Acetonitrile
Synonyms
AN; Methyl cyanide; Ethanenitrile

Regulatory Identifiers

CAS Number
75-05-8 Check regulations →
EC Number
200-835-2 Check regulations →
REACH No.
01-2119471307-38

Identified Uses

Laboratory chemicals. SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites; PC21 - Laboratory chemicals; PROC15 - Use as a laboratory reagent; ERC6a - Industrial use resulting in manufacture of another substance (use of intermediates)

Uses advised against

No Information available

Manufacturers & Suppliers

T

Thermo Fisher Scientific

manufacturer

Janssen Pharmaceuticalaan 3a, 2440 Geel, Belgium

F

Fisher Scientific UK

distributor

Bishop Meadow Road, Loughborough, Leicestershire LE11 5RG, United Kingdom

F

Fisher Scientific AG

distributor

Neuhofstrasse 11, CH 4153 Reinach

+41 (0) 56 618 41 11

Emergency Contacts

Thermo Fisher Scientific (US Info)

001-800-227-6701

Thermo Fisher Scientific (Europe Info)

+32 14 57 52 11

Thermo Fisher Scientific (US Emergency)

001-201-796-7100

Thermo Fisher Scientific (Europe Emergency)

+32 14 57 52 99

CHEMTREC

001-800-424-9300

CHEMTREC

001-703-527-3887

Tox Info Suisse

145

24hr

Tox Info Suisse

+41-44 251 51 51

Chemtrec

0800 564 402

24h

Chemtrec

+41-43 508 20 11

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Flam. Liq. Cat. 2 H225
Acute Tox. Cat. 4 H302
Acute Tox. Cat. 4 H312
Acute Tox. Cat. 4 H332
Eye Irrit. Cat. 2 H319

GHS Pictograms

GHS02 - Flammable

GHS02

GHS07 - Health hazard

GHS07

Hazard Statements

H225 Highly flammable liquid and vapor
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
H319 Causes serious eye irritation

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking
P280 Wear protective gloves/protective clothing/eye protection/face protection
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P302 + P352 IF ON SKIN: Wash with plenty of soap and water
P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Acetonitrile EC: 200-835-2 75-05-8 95% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Remove to fresh air. If breathing is irregular or stopped, administer artificial respiration. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Immediate medical attention is required.

Symptoms: Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting.

Skin contact

Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

Eye contact

Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.

Ingestion

Do NOT induce vomiting. Call a physician or poison control center immediately.

Symptoms: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.

Immediate Medical Attention

Immediate medical attention is required. Call a physician or poison control center immediately.

Medical Treatment

Treat symptomatically. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water spray. CO₂, dry chemical, dry sand, alcohol-resistant foam. Water mist may be used to cool closed containers.

Unsuitable media

Do not use a solid water stream as it may scatter and spread fire.

Specific hazards

Flammable. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Containers may explode when heated. Vapors may form explosive mixtures with air.

Instructions

Thermal decomposition can lead to release of irritating gases and vapors.

Firefighter Protection

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Remove all sources of ignition. Take precautionary measures against static discharges. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Ensure adequate ventilation. Use personal protective equipment as required.

Environmental

Should not be released into the environment.

Cleanup methods

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Materials: inert absorbent material

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Wear personal protective equipment/face protection. Ensure adequate ventilation. Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges. Do not get in eyes, on skin, or on clothing. Do not breathe mist/vapors/spray. Use spark-proof tools and explosion-proof equipment. Use only non-sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded.

Storage

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat, sparks and flame. Flammables area.

Hygiene

When using do not eat, drink or smoke. Provide regular cleaning of equipment, work area and clothing.

Fire prevention

Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Use explosion-proof electrical/ventilating/lighting/equipment. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source

Hands

Protective gloves. Glove material: Butyl rubber, Breakthrough time: >480 minutes, Glove thickness: 0.35 mm, EU standard: EN 374, Glove comments: As tested under EN374-3 Determination of Resistance to Permeation by Chemicals. Neoprene gloves, Breakthrough time: <60 minutes, Glove thickness: 0.45 mm, EU standard: Level 6.

Eyes

Goggles (European standard - EN 166)

Respiratory

When workers are facing concentrations above the exposure limit they must use appropriate certified respirators. To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly. Large scale/emergency use: Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended Filter type: low boiling organic solvent Type AX Brown conforming to EN371. Small scale/Laboratory use: Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141

Skin/Body

Wear appropriate protective gloves and clothing to prevent skin exposure. Inspect gloves before use. observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. (Refer to manufacturer/supplier for information) gloves are suitable for the task: Chemical compatibility, Dexterity, Operational conditions, User susceptibility, e.g. sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion. gloves with care avoiding skin contamination.

Environmental

No information available.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Physical State
Liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
Colorless
Colour
---
Colour Intensity
---
Form
---
Odor
aromatic
Odor Threshold
170 ppm
Ph
No information available
Melting Point
-46 °C / -50.8 °F
Boiling Point
81 - 82 °C / 177.8 - 179.6 °F
Flash Point
12.8 °C / 55 °F
Freezing Point
---
Softening Point
No data available
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
5.79 - (Butyl Acetate = 1.0)
Vapor Pressure
97 mbar @ 20 °C
Vapor Density
1.42
Relative Density
---
Bulk Density
Not applicable
Density
0.781
Flammability
Highly flammable
Upper Explosive Limit
16 vol %
Lower Explosive Limit
3 vol %
Explosive Limits
---
Auto Ignition Temperature
525 °C / 977 °F
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
-0.34
Solubility In Water
Miscible
Solubility In Fat
---
Molecular Weight
41.05
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
0.36 cP at 20 °C
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

None known, based on information available

Hazardous reactions

Hazardous polymerization does not occur. No information available.

Avoid

Incompatible products. Keep away from open flames, hot surfaces and sources of ignition. Exposure to moisture.

Incompatible

Strong oxidizing agents. Strong acids. Reducing Agent. Bases.

Decomposition

Hydrogen cyanide (hydrocyanic acid). Nitrogen oxides (NOx). Carbon monoxide (CO). Carbon dioxide (CO₂).

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
UN1648
Shipping Name
ACETONITRILE
Transport Class
3
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What other names is Acetonitrile known by?

Acetonitrile is also known as: AN; Methyl cyanide; Ethanenitrile

What is the hazard signal word for Acetonitrile?

The signal word is danger.

What is the physical form of Acetonitrile?

Acetonitrile is a liquid appearing as colorless . It has aromatic odor.

What is Acetonitrile used for?

Laboratory chemicals. SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites; PC21 - Laboratory chemicals; PROC15 - Use as a laboratory reagent; ERC6a - Industrial use resulting in manufacture of another substance (use of intermediates)

What are the hazard statements for Acetonitrile?

This substance has 3 hazard statements:

  • H225: Highly flammable liquid and vapor
  • H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled
  • H319: Causes serious eye irritation

What is the melting point of Acetonitrile?

The melting point is -46 °C / -50.8 °F and the boiling point is 81 - 82 °C / 177.8 - 179.6 °F.