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Safety Data Sheet EN

Acetonitrile

CAS 75-05-8

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Acetonitrile
Product Code
271004
Chemical Name
Acetonitrile

Regulatory Identifiers

CAS Number
75-05-8 Check regulations →

Identified Uses

Laboratory chemicals, Synthesis of substances

Manufacturers & Suppliers

S

Sigma-Aldrich Inc.

manufacturer

3050 SPRUCE ST, ST. LOUIS MO 63103, UNITED STATES

+1 314 771-5765

Emergency Contacts

CHEMTREC

800-424-9300

24 Hours/day; 7 Days/week

CHEMTREC

+1-703-527-3887

24 Hours/day; 7 Days/week

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Flam. Liq. Cat. 2 H225
Acute Tox. Cat. 4 H302
Acute Tox. Cat. 4 H332
Acute Tox. Cat. 4 H312
Eye Irrit. Cat. 2A H319

GHS Pictograms

GHS02 - Flammable

GHS02

GHS07 - Health hazard

GHS07

Hazard Statements

H225 Highly flammable liquid and vapor.
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled.
H319 Causes serious eye irritation.

Precautionary Statements

P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing mist or vapors.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P363 Wash contaminated clothing before reuse.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P403 + P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/ container to an approved waste disposal plant.
IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor if you feel unwell.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Acetonitrile EC: 200-835-2 75-05-8 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

After inhalation: fresh air. If breathing stops: mouth-to-mouth breathing or artificial respiration. Oxygen if necessary. Immediately call in physician.

Skin contact

Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

Eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

Ingestion

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water, Foam, Carbon dioxide (CO2), Dry powder

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Combustible. Fire may cause evolution of: nitrogen oxides, Hydrogen cyanide (hydrocyanic acid). Pay attention to flashback. Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Instructions

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental

Do not let product enter drains. Risk of explosion.

Cleanup methods

Take up with liquid-absorbent material (e.g. Chemizorb®). Clean up affected area.

Materials: liquid-absorbent material (e.g. Chemizorb®)

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Filled under nitrogen. Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Storage

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Fire prevention

Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Full contact: Material: butyl-rubber, Minimum layer thickness: 0.7 mm, Break through time: 480 min, Material tested: Butoject® (KCL 898). Splash contact: Material: Chloroprene, Minimum layer thickness: 0.65 mm, Break through time: 10 min, Material tested: KCL 720 Camapren®.

Eyes

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Respiratory

Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds. Required when vapours/aerosols are generated. Recommendations based on standards: DIN EN 143, DIN 14387.

Skin/Body

Flame retardant antistatic protective clothing.

Environmental

Do not let product enter drains. Risk of explosion.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Physical State
clear, liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
clear, liquid
Colour
colorless
Colour Intensity
---
Form
clear, liquid
Odor
ether-like
Odor Threshold
39.8 ppm
Ph
No data available
Melting Point
-48 °C (-54 °F)
Boiling Point
81 - 82 °C 178 - 180 °F
Flash Point
2.0 °C (35.6 °F) - closed cup
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
5.8
Vapor Pressure
98.64 hPa at 20 °C (68 °F)
Vapor Density
1.42 - (Air = 1.0)
Relative Density
No data available
Bulk Density
---
Density
0.786 g/mL at 25 °C (77 °F)
Flammability
No data available
Upper Explosive Limit
16 % (V)
Lower Explosive Limit
4.4 % (V)
Explosive Limits
---
Auto Ignition Temperature
No data available
Decomposition Temperature
No data available
Solubility
---
Partition Coefficient
log Pow: -0.54 at 25 °C (77 °F) - Bioaccumulation is not expected.
Solubility In Water
1,000 g/l at 25 °C (77 °F) completely soluble
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
---
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

Vapors may form explosive mixture with air.

Hazardous reactions

Violent reactions possible with: Strong bases, strong reducing agents. Risk of explosion with: nitrates, perchlorates, perchloric acid, conc. sulfuric acid, with Heat. Risk of ignition or formation of inflammable gases or vapours with: Oxidizing agents, Nitric acid, nitrogen dioxide, with Catalyst. Generates dangerous gases or fumes in contact with: Acids

Avoid

Warming.

Incompatible

No data available

Decomposition

In the event of fire: see section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Leave chemicals in original containers. No mixing with other waste.

Disposal

Waste material must be disposed of in accordance with the national and local regulations.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
1648
Shipping Name
Acetonitrile
Transport Class
3
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Acetonitrile?

The signal word is danger.

What is the physical form of Acetonitrile?

Acetonitrile is a clear, liquid appearing as clear, liquid with colorless color. It has ether-like odor.

What is Acetonitrile used for?

Laboratory chemicals, Synthesis of substances

What are the hazard statements for Acetonitrile?

This substance has 3 hazard statements:

  • H225: Highly flammable liquid and vapor.
  • H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.
  • H319: Causes serious eye irritation.

What is the melting point of Acetonitrile?

The melting point is -48 °C (-54 °F) and the boiling point is 81 - 82 °C 178 - 180 °F.