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Safety Data Sheet EN

NucleoSpin DNA RapidLyse (50)

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
NucleoSpin DNA RapidLyse (50)
Product Code
740100.50

Regulatory Identifiers

CAS Number
N/A
REACH No.
A registration number for the substance(s) does not exist because the annual tonnage does not require registration or the substance or its use is excluded from registration.
UFI Code
TTWV-43C9-R202-NTGN, D0HW-E3PF-P200-V61A, GXGW-X302-C20G-6UF8

Identified Uses

Product for analytical use. Exposure Scenario Classification according REACH, RIP 3.2 Codes: SU 0-2, PC 21, PROC 15, AC 0 The exposure scenario is integrated into sections 1-16.

Uses advised against

not described

Manufacturers & Suppliers

M

MACHEREY-NAGEL GmbH & Co. KG

manufacturer

Valenciennen Str. 11, 52355 Düren, Germany

+49 2421 969 0

Emergency Contacts

Gemeinsames Giftinformationszentrum (GGIZ)

+49 361 730 730

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Flam. Liq. Cat. 3 H226
Acute Tox. Cat. 4 H302
Skin Corr. Cat. 1B H314
Skin Sens. Cat. 1 H317
Eye Dam. Cat. 1 H318
Aquatic Chronic Cat. 2 H411
Aquatic Chronic Cat. 3 H412
Eye Irrit. Cat. 2 H319
Aquatic Chronic Cat. 3 H412
Resp. Sens. Cat. 1 H334

GHS Pictograms

GHS02 - Flammable

GHS02

GHS05 - Corrosive

GHS05

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

GHS09 - Environmental hazard

GHS09

Hazard Statements

H314 Causes severe skin burns and eye damage.
H317 May cause an allergic skin reaction.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statements

P260 Do not breathe dust/vapours.
P264 Wash hands thoroughly after handling.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/eye protection.
P284 [In case of inadequate ventilation] wear respiratory protection.
P310 Immediately call a POISON CENTER/doctor.
P405 Store locked up.
P501 Dispose of contents/container to regulated waste treatment.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
If skin irritation or rash occurs: Get medical advice/attention.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture

NucleoSpin DNA RapidLyse (50) is a kit containing multiple components (RLB, RLY, RLW, RLE, Proteinase K).

Chemical Name CAS Number Concentration Hazardous
1-dodecylpyridiniumchloride EC: 203-232-2 104-74-5 2.5 - 5% Yes
guanidinium thiocyanate EC: 209-812-1 593-84-0 30 - 45% Yes
ethanol EC: 200-578-6 64-17-5 5 - 20% Yes
dodecyl sulfate, sodium salt EC: 205-788-1 151-21-3 2.5 - 3% Yes
dodecyl sulfate, sodium salt EC: 205-788-1 151-21-3 1 - 2.5% No
proteinase K, liquid EC: 254-457-8 39450-01-6 1 - 3% Yes
glycerole EC: 200-289-5 56-81-5 10 - 50% No
chemicals/mixture until 1% --- 0.1 - 1% No

Notes

When not listed, mixtures are added with water [CAS No. 7732-18-5] to 100%.

04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

After inhalation of foam or vapour fresh air should be inhaled. Keep airways free. If vomiting and if insensible place patient in recovery position and keep airways free. Administer a Dexamethasone spray as soon as possible. Ensure quiet, warmth, and provide resuscitation if necessary. In the event of respiratory distress ensure that the patient inhales oxygen. Secure the breathing, heart and circulatory function.

Symptoms: respiratory distress

Skin contact

Remove contaminated clothing immediately. Rinse the affected skin or mucous membrane thoroughly for min. 15 minutes under running water. (If possible) use soap. Avoid neutralisation. Then apply a loose bandage.

Symptoms: Rapid penetration and destruction of the skin. Especially in the heated form. Causes severe skin burns.

Eye contact

After contact with the eyes rinse thoroughly under running water with the eyelid wide open for min. 10 minutes with eye washing bottle, eye douche or running water (protect intact eye). Before (if possible) apply eye drops Proxymetacaine 0.5%, if the opening the eyelid convulsion is painful. Further treatment to be carried out by an eye specialist.

Symptoms: convulsion

Ingestion

After oral intake lots of water with activated charcoal supplement should be drunk after it has been ingested. Do not induce vomiting under any circumstances. Do not make any efforts to neutralise it. Contact medical advice for possible consequences.

Immediate Medical Attention

Contact medical advice for possible consequences. Take to a doctor, in a raised position if there are breathing difficulties.

Medical Treatment

Further treatment to be carried out by an eye specialist. Administer a Dexamethasone spray as soon as possible. In the event of respiratory distress ensure that the patient inhales oxygen. Secure the breathing, heart and circulatory function.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Fire extinguishers appropriate to the fire classification, and, if applicable, a fire blanket must be available in a prominent location in the work area. All extinguishers like FOAM, WATER SPRAY, DRY POWDER, CARBON DIOXIDE can be used.

Unsuitable media

no data available

Specific hazards

Flammable (GHS regulation). May form explosive vapour-air mixtures. Formation of hazardous and caustic vapour-air mixtures possible.

Instructions

Spray any vapours released with water. Retent fire water. Use only acid-resistant safety equipment.

Firefighter Protection

For great amount - if necessary - protective breathing apparatus which is independent of the ambient air (isolated equipment), and sealed protective clothing is necessary in the event of a large-scale formation of toxic substances.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Regular staff training is necessary, indicating hazards and precautions on the basis of operating instructions. Restrictions on activity must be observed.

Small spill

Collect small amounts of leaked liquid and flush with water into drains.

Environmental

Should not be released into the environment.

Cleanup methods

Clean any contaminated equipment and floors with plenty of water.

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Handling in accordance with the test instruction, that comes with the product.

Storage

Safe storage is guaranteed in the original packaging from MACHEREY-NAGEL. Keep original product packages tightly closed during handling and storage.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Good ventilation and extraction system in the room, floor resistant to chemicals with floor drainage and washing facilities.

Hands

Yes, gloves according EN 374 (permeation time >30 min - level 2), consist of PVC, natural latex, Neopren, or Nitril (f.ex. from Ansell or KCL). Use for short times chemical resistant latex gloves with code EN 374-3 level 1.

Eyes

Yes, safety glasses according EN 166 with integrated side shields or wrap-around protection or face protection.

Respiratory

Use for open access of these substances for example a protection filter, class A/AX. No additional recommendations.

Skin/Body

Recommended to avoid clothing damage, and to avoid contamination with these hazards.

Environmental

Do not release product into environment.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Upper Explosive Limit
no data available
Freezing Point
---
Crystallisation Point
---
Relative Density
---
Cloud Point
---
Voc Content
---
Solubility
---
Melting Point
no data available
Partition Coefficient
---
Decomposition Temperature
no data available
Lower Explosive Limit
no data available
Molecular Weight
---
Properties Status
---
Form
---
Evaporation Rate
---
Softening Point
---
Flammability
no data available
Solubility In Fat
---
Colour Intensity
---
Odor Threshold
---
Solidification Point
---
Ph
8.5-9.5 (RLY), 6.5-7.5 (RLB), 7-8 (RLW), 8-9 (RLE), 7-8 (Proteinase K)
Flash Point
no data available
Kinematic Viscosity
no data available
Bulk Density
---
Boiling Point
no data available
Physical State
liquid
Dynamic Viscosity
---
Relative Evaporation Rate
---
Auto Ignition Temperature
---
Colour
colourless (RLY, RLW, RLE, Proteinase K), slightly yellow (RLB)
State Under Standard Conditions
---
Density
1.01 g/cm³ (RLY), 1.00 g/cm³ (RLW), 1.0 g/cm³ (RLE), 1.1 g/cm³ (Proteinase K)
Appearance
---
Explosive Limits
---
Physical State Data
liquid
Vapor Density
---
Solubility In Water
0-100 % (Proteinase K), no data available (others)
Metal Corrosion
highly corrosive
Vapor Pressure
no data available
Odor
odorless (RLY, RLW, RLE, Proteinase K), alcoholic (RLB)
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

no known instability.

Reactivity

no further data available.

Hazardous reactions

Can react violently with organic material. Note: Can form very reactive substances with oxidizing agents. Possible: &H:EUH031&

Avoid

No more required.

Incompatible

no additional data available

Decomposition

In the original package all parts/all reagents are safety and separated stored. Decompositions are not observed during the expiration period under recommended conditions.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for NucleoSpin DNA RapidLyse (50)?

The signal word is danger.

What is the physical form of NucleoSpin DNA RapidLyse (50)?

NucleoSpin DNA RapidLyse (50) is a liquid with colourless (rly, rlw, rle, proteinase k), slightly yellow (rlb) color. It has odorless (rly, rlw, rle, proteinase k), alcoholic (rlb) odor.

What is NucleoSpin DNA RapidLyse (50) used for?

Product for analytical use. Exposure Scenario Classification according REACH, RIP 3.2 Codes: SU 0-2, PC 21, PROC 15, AC 0 The exposure scenario is integrated into sections 1-16.

What are the hazard statements for NucleoSpin DNA RapidLyse (50)?

This substance has 3 hazard statements:

  • H314: Causes severe skin burns and eye damage.
  • H317: May cause an allergic skin reaction.
  • H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

What is the melting point of NucleoSpin DNA RapidLyse (50)?

The melting point is no data available and the boiling point is no data available.