NextSDS Logo
Safety Data Sheet EN

NEONATAL Biotinidase Screening Assay

Keep this SDS organized and up to date

Add this SDS to your NextSDS library and keep all its safety information in one place.

Add to my SDS library for free
01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
NEONATAL Biotinidase Screening Assay
Product Code
E-KH-480-1920

Regulatory Identifiers

CAS Number
N/A

Identified Uses

For in vitro diagnostic use only

Manufacturers & Suppliers

L

LaCAR MDx technologies

manufacturer

Liège Science Park, Rue des Chasseurs Ardennais,10, 4031 Liège, Belgium

+32 (0) 4 287 39 44

Emergency Contacts

Emergency Contact

+1 703 527 3887

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Repr. Cat. 1B H360FD
Met. Corr. Cat. 1 H290
Skin Corr. Cat. 1A H314
Eye Dam. Cat. 1 H318
STOT SE Cat. 3 H335
Aquatic Acute Cat. 1 H400
Aquatic Chronic Cat. 1 H410

GHS Pictograms

GHS05 - Corrosive

GHS05

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

GHS09 - Environmental hazard

GHS09

Hazard Statements

H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
H318 Causes serious eye damage.
H335 May irritate the respiratory tract.
H360FD May damage fertility. May damage the unborn child.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic organisms, causes effects.

Precautionary Statements

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P234 Keep only in original packaging.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P330 + P331 IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P310 Immediately call a POISON CENTER/doctor/...
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.

Still copying SDS data manually?Free

You don't have to. NextSDS reads this SDS and adds the information to your library automatically.

Let NextSDS do it for me
03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture
Chemical Name CAS Number Concentration Hazardous
EDTA EC: 205-358-3 6381-92-6 1% Yes
Sodium nitrite EC: 231-555-9 7632-00-0 --- Yes
Boric acid EC: 233-139-2 10043-35-3 100% Yes
Sulfuric acid EC: 231-639-5 7664-93-9 15% Yes
NED EC: 215-981-2 1465-25-4 1% Yes
Tricholoracetic acid (TCA) EC: 200-927-2 76-03-9 1% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Move to fresh air. Call a physician. If breathing is difficult, supply oxygen.

Skin contact

Take off immediately all contaminated clothing. Rinse skin with water/shower. For specific reagents: wash abundantly with soap and water, rinse thoroughly, and disinfect with a 1/10 dilution of 12% liquid bleach. Leave the disinfectant in contact for 5 minutes. Consult a hospital emergency medical department immediately.

Eye contact

Rinse immediately with plenty of water, keeping the eyelids wide open for at least 15 minutes. Remove contact lenses. Call in ophthalmologist or doctor immediately.

Ingestion

Make victim drink water (two glasses at most). Do not induce vomiting (risk of perforation). Do not attempt to neutralise. Consult a physician or hospital emergency medical department immediately.

Immediate Medical Attention

Consult a physician or hospital emergency medical department immediately.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Boric acid: Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Sulfuric acid: Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Trichloroacetic acid: Water, Foam, Carbon dioxide (CO2), Dry powder.

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Borane/boron oxides, Sulfur oxides, Carbon oxides, Hydrogen chloride gas. Fire may cause evolution of boron compounds, sulfur oxides, and hazardous combustion gases or vapours.

Instructions

Suppress (knock down) gases / vapors / mists with a water spray jet.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental

Do not let product enter drains.

Cleanup methods

Take up carefully. Dispose of properly. Clean up affected area. Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No. 101595).

Materials: liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No. 101595)

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Work under hood. Do not inhale substance/mixture.

Storage

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. No metal containers.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Boric acid: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: KCL 741 Dermatril® L. Sulfuric acid: Full contact: Viton®, Minimum layer thickness: 0,7 mm, Break through time: 480 min, Material tested: Vitoject® (KCL 890 / Aldrich Z677698, Size M); Splash contact: butyl-rubber, Minimum layer thickness: 0,7 mm, Break through time: 120 min, Material tested: Butoject® (KCL 898). Trichloroacetic acid: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: KCL 741 Dermatril® L.

Eyes

Boric acid: Safety glasses (tested and approved under NIOSH (US) or EN 166(EU)). Sulfuric acid: Tightly fitting safety goggles (tested and approved under NIOSH (US) or EN 166(EU)). Trichloroacetic acid: Tightly fitting safety goggles (tested and approved under NIOSH (US) or EN 166(EU)).

Respiratory

Boric acid: Required when dusts are generated, Filter type P3. Sulfuric acid: Required when vapours/aerosols are generated, Filter B-(P2). Trichloroacetic acid: Filter type B. Standards: DIN EN 143, DIN 14387 and other accompanying standards.

Skin/Body

Boric acid: Protective clothing. Sulfuric acid: Acid-resistant protective clothing. Trichloroacetic acid: Acid-resistant protective clothing.

Environmental

Do not let product enter drains.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
Solid, Liquid, Solid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
White (Boric acid), Colorless (Sulfuric acid), Off-White (Trichloroacetic acid)
Colour
White, Colorless, Off-White
Colour Intensity
---
Form
Solid, Liquid, Crystalline
Odor
Odorless, Odorless, Stinging
Odor Threshold
No data available
Ph
5,1 at 1,8 g/l (Boric acid); 0,3 at 49 g/l (Sulfuric acid); 1 at 81.7 g/L (Trichloroacetic acid)
Melting Point
Boric acid: > 1.000 °C - Regulation (EC) No. 440/2008, Annex, A.1; Sulfuric acid: -20 °C; Trichloroacetic acid: 54-58°C – lit
Boiling Point
Trichloroacetic acid: 196°C - lit
Flash Point
Trichloroacetic acid: > 113°C – closed cup
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
---
Vapor Pressure
< 0,1 hPa at 25 °C - Regulation (EC) No. 440/2008, Annex, A.4 (Boric acid); ca.0,0001 hPa at 20 °C (Sulfuric acid); 1 hPa at 51°C (Trichloroacetic acid)
Vapor Density
---
Relative Density
1,49 at 23 °C - Regulation (EC) No. 440/2008, Annex, A.3 (Boric acid)
Bulk Density
Boric acid: ca.400 - 600 kg/m3; sulfuric acid: Not applicable
Density
1,48 g/cm3 at 23 °C - OECD Test Guideline 109 (Boric acid); 1,84 g/cm3 at 20 °C (Sulfuric acid)
Flammability
The product is not flammable. - Flammability (solids) (Boric acid); Non-flammable (Trichloroacetic acid)
Upper Explosive Limit
---
Lower Explosive Limit
---
Explosive Limits
---
Auto Ignition Temperature
Does not ignite (Trichloroacetic acid)
Decomposition Temperature
---
Solubility
---
Partition Coefficient
log Pow: -1,09 at 22 °C - Regulation (EC) No. 440/2008, Annex, A.8 - Bioaccumulation is not expected. (Boric acid); Log Pow: 1.33 – Bioaccumulation is not expected (Trichloroacetic acid)
Solubility In Water
49,2 g/l at 20 °C - Regulation (EC) No. 440/2008, Annex, A.6- completely soluble (Boric acid); at 20 °C soluble, (caution ! development of heat) (Sulfuric acid); 81.7 g/L at 20°C – completely soluble (Trichloroacetic acid)
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
ca.24 mPa.s at 20 °C (Sulfuric acid)
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The products are chemically stable under standard ambient conditions (room temperature).

Reactivity

Boric acid (CAS-No: 10043-35-3): No data available; Sulfuric acid (CAS-No: 7664-93-9): Has a corrosive effect Strong oxidising agent; Tricholoracetic acid (CAS No: 76-03-9): The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Hazardous reactions

Boric acid: Risk of explosion with: Acetic anhydride; Violent reactions possible with: Strong oxidising agents, Bases. Sulfuric acid: A risk of explosion and/or of toxic gas formation exists with the following substances: Alkali metals, Alkali compounds, Ammonia, Aldehydes, Acetonitrile, Alkaline earth metals, Alkalines, Acids, Alkaline earth compounds, Metals, Metal alloys, Oxides of phosphorus, Phosphorus, Hydrides, Halogen-halogen compounds, Oxyhalogenic compounds, Permanganates, nitrates, Carbides, Combustible substances, Organic solvent, Acetylidene, Nitriles, Organic nitro compounds, Anilines, Peroxides, Picrates, Nitrides, Lithium silicide, Iron(III) compounds, Bromates, Chlorates, Amines, Perchlorates, Hydrogen peroxide. Trichloroacetic acid: Risk of explosion with: Silver salt; Exothermic reaction with: alkalines, alkali hydroxides, Amines, Strong oxidizing agents, sulfoxides, dimethyl sulfoxide with Copper.

Avoid

Boric acid: no information available; Sulfuric acid: no information available; Tricholoracetic acid: Exposure to moisture, Heat.

Incompatible

Boric acid: Potassium, Acid anhydrides; Sulfuric acid: Animal/vegetable tissues, Metals (Contact with metals liberates hydrogen gas); Trichloroacetic acid: Metals

Decomposition

In the event of fire: see section 5.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

12.1. Toxicity

Boric acid (CAS-No: 10043-35-3): Toxicity to fish: static test LC50 - Pimephales promelas (fathead minnow) - 79,7 mg/l - 96 h Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - 133 mg/l - 48 h. Remarks: (ECOTOX Database). Toxicity to algae: static test EC50 - Pseudokirchneriella subcapitata (green algae) - 52,4 mg/l - 74,5 h (OECD Test Guideline 201)

12.1. Toxicity

Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h (sulphuric acid) (OECD Test Guideline 202) Toxicity to algae: static test ErC50 - Desmodesmus subspicatus (green algae) - > 100 mg/l - 72 h (sulphuric acid) (OECD Test Guideline 201)

12.2. Persistence and degradability

The methods for determining the biological degradability are not applicable to inorganic substances. No data available for Tricholoracetic acid (CAS No: 76-03-9).

12.3. Bioaccumulative potential

No data available

12.4. Mobility in soil

No data available

12.5. Results of PBT and vPvB assessment

All the substances/mixtures contain no components considered to be either PBT or vPvB at levels of 0.1% or higher.

The substances/mixtures do not contain PBT or vPvB components at concentrations of 0.1% or higher.

12.6. Endocrine disrupting properties

| Boric acid (CAS-No: 10043-35-3) | Sulfuric acid (CAS-No: 7664-93-9) | Tricholoracetic acid (CAS No: 76-03-9) | | --- | --- | --- | | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. | No data available |

The substances listed do not contain components considered to have endocrine disrupting properties at levels of 0.1% or higher, with the exception of Tricholoracetic acid for which no data is available.

12.7. Other adverse effects

Boric acid (CAS-No: 10043-35-3): Discharge into the environment must be avoided. Sulfuric acid (CAS-No: 7664-93-9): Biological effects: Harmful effect due to pH shift. Caustic even in diluted form. Does not cause biological oxygen deficit. Endangers drinking-water supplies if allowed to enter soil and/or waters in large quantities. Neutralisation possible in waste water treatment plants. Discharge into the environment must be avoided. Tricholoracetic acid (CAS No: 76-03-9): Biological effects: Caustic even in diluted form. Discharge into the environment must be avoided.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Disposal

No data available for Boric acid (CAS-No: 10043-35-3)

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
1830
Shipping Name
SULPHURIC ACID
Transport Class
8
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

This safety datasheet complies with the requirement of Regulation (EC) No 1907/2006.

Chemical Safety Assessment Not performed
?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for NEONATAL Biotinidase Screening Assay?

The signal word is danger.

What is the physical form of NEONATAL Biotinidase Screening Assay?

NEONATAL Biotinidase Screening Assay is a solid, liquid, solid appearing as white (boric acid), colorless (sulfuric acid), off-white (trichloroacetic acid) with white, colorless, off-white color. It has odorless, odorless, stinging odor.

What is NEONATAL Biotinidase Screening Assay used for?

For in vitro diagnostic use only

What are the hazard statements for NEONATAL Biotinidase Screening Assay?

This substance has 7 hazard statements:

  • H290: May be corrosive to metals.
  • H314: Causes severe skin burns and eye damage.
  • H318: Causes serious eye damage.
  • H335: May irritate the respiratory tract.
  • H360FD: May damage fertility. May damage the unborn child.
  • H400: Very toxic to aquatic life.
  • H410: Very toxic to aquatic organisms, causes effects.

What is the melting point of NEONATAL Biotinidase Screening Assay?

The melting point is Boric acid: > 1.000 °C - Regulation (EC) No. 440/2008, Annex, A.1; Sulfuric acid: -20 °C; Trichloroacetic acid: 54-58°C – lit and the boiling point is Trichloroacetic acid: 196°C - lit.