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Safety Data Sheet EN

TNA Lysis Buffer

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
TNA Lysis Buffer

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Laboratory Use

Manufacturers & Suppliers

Omega Bio-tek logo

Omega Bio-tek

manufacturer

400 Pinnacle Way, Suite 450 Georgia 30071 United States

+1 770 931 8400

http://www.omegabiotek.com/

Emergency Contacts

CHEMTREC

+1 800 424 9300

CHEMTREC

+1 703 527 3887

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Acute Tox. Cat. 4
Eye Dam. Cat. 1
Skin Sens. Cat. 1
Skin Corr. Cat. 1A
Aquatic Chronic Cat. 3
Aquatic Acute Cat. 2

GHS Pictograms

GHS05 - Corrosive

GHS05

GHS07 - Health hazard

GHS07

Hazard Statements

H302 Harmful if swallowed.
H312 Harmful in contact with skin.
H314 Causes severe skin burns and eye damage.
H317 May cause an allergic skin reaction.
H332 Harmful if inhaled.
H401 Toxic to aquatic life.
H412 Harmful to aquatic life with long lasting effects.

Precautionary Statements

P260 Do not breathe mist/vapours/spray.
P261 Avoid breathing mist/vapours/spray.
P264 Wash all exposed external body areas thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing must not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves, protective clothing, eye protection and face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER/doctor/physician/first aider/if you feel unwell.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P352 IF ON SKIN: Wash with plenty of water and soap.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER/doctor/physician/first aider.
P312 Call a POISON CENTER/doctor/physician/first aider/if you feel unwell.
P330 Rinse mouth.
P333 + P313 If skin irritation or rash occurs: Get medical advice/attention.
P362 + P364 Take off contaminated clothing and wash it before reuse.
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/container to authorised hazardous or special waste collection point in accordance with any local regulation.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type mixture
Chemical Name CAS Number Concentration Hazardous
quinidine thiocyanate 593-84-0 50 - 100% No
Anionic detergent --- 5 - 10% No
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

If fumes or combustion products are inhaled remove from contaminated area. Lay patient down. Keep warm and rested. Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures. Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary. Transport to hospital, or doctor.

Skin contact

Immediately flush body and clothes with large amounts of water, using safety shower if available. Quickly remove all contaminated clothing, including footwear. Wash skin and hair with running water. Continue flushing with water until advised to stop by the Poisons Information Centre. Transport to hospital, or doctor.

Eye contact

Immediately hold eyelids apart and flush the eye continuously with running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. Continue flushing until advised to stop by the Poisons Information Centre or a doctor, or for at least 15 minutes. Transport to hospital or doctor without delay. Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.

Ingestion

For advice, contact a Poisons Information Centre or a doctor at once. Urgent hospital treatment is likely to be needed. If swallowed do NOT induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. Observe the patient carefully. Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious. Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink. Transport to hospital or doctor without delay.

Immediate Medical Attention

Urgent hospital treatment is likely to be needed.

Medical Treatment

For thiocyanate poisonings haemodialysis is recommended as the treatment of choice. Phenobarbital protects poisoned animals against death. Thiocyanate ion is slowly excreted in the urine and is not decomposed to any appreciable degree to cyanide.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Foam. Dry chemical powder. BCF (where regulations permit). Carbon dioxide. Water spray or fog - Large fires only.

Specific hazards

Combustible. Slight fire hazard when exposed to heat or flame. Heating may cause expansion or decomposition leading to violent rupture of containers. Mists containing combustible materials may be explosive. May emit poisonous fumes. May emit corrosive fumes.

Instructions

Alert Fire Brigade and tell them location and nature of hazard. Prevent, by any means available, spillage from entering drains or water course. Use water delivered as a fine spray to control fire and cool adjacent area. Avoid spraying water onto liquid pools. DO NOT approach containers suspected to be hot. Cool fire exposed containers with water spray from a protected location. If safe to do so, remove containers from path of fire.

Firefighter Protection

Wear full body protective clothing with breathing apparatus.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Clear area of personnel and move upwind. Alert Fire Brigade. Stop leak if safe to do so.

Small spill

Remove all ignition sources. Clean up all spills immediately. Avoid breathing vapours and contact with skin and eyes. Control personal contact with the substance, by using protective equipment. Contain and absorb spill with sand, earth, inert material or vermiculite. Wipe up. Place in a suitable, labelled container for waste disposal.

Large spill

Clear area of personnel and move upwind. Alert Fire Brigade and tell them location and nature of hazard. Wear breathing apparatus plus protective gloves. Prevent, by any means available, spillage from entering drains or water course. No smoking, naked lights or ignition sources. Increase ventilation. Stop leak if safe to do so. Contain spill with sand, earth or vermiculite. Collect recoverable product into labelled containers for recycling. Absorb remaining product with sand, earth or vermiculite. Collect solid residues and seal in labelled drums for disposal. Wash area and prevent runoff into drains. If contamination of drains or waterways occurs, advise emergency services.

Environmental

Prevent, by any means available, spillage from entering drains or water course.

Cleanup methods

Wipe up. Collect recoverable product into labelled containers for recycling. Absorb remaining product with sand, earth or vermiculite. Collect solid residues and seal in labelled drums for disposal. Wash area and prevent runoff into drains.

Materials: sand, earth, inert material or vermiculite

—

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid all personal contact, including inhalation. Wear protective clothing when risk of exposure occurs. Use in a well-ventilated area. Prevent concentration in hollows and sumps. DO NOT enter confined spaces until atmosphere has been checked. Avoid smoking, naked lights or ignition sources. Avoid contact with incompatible materials. When handling, DO NOT eat, drink or smoke. Keep containers securely sealed when not in use. Avoid physical damage to containers. Always wash hands with soap and water after handling. Work clothes should be laundered separately. Use good occupational work practice. Observe manufacturer's storage and handling recommendations contained within this SDS. Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions. DO NOT allow clothing wet with material to stay in contact with skin

Storage

Store in original containers. Keep containers securely sealed. Store in a cool, dry, well-ventilated area. Store away from incompatible materials and foodstuff containers. Protect containers against physical damage and check regularly for leaks.

Hygiene

Always wash hands with soap and water after handling. Work clothes should be laundered separately. When handling, DO NOT eat, drink or smoke.

Fire prevention

Avoid smoking, naked lights or ignition sources.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed engineering controls can be highly effective in protecting workers and will typically be independent of worker interactions to provide this high level of protection. The basic types of engineering controls are: Process controls which involve changing the way a job activity or process is done to reduce the risk. Enclosure and/or isolation of emission source which keeps a selected hazard 'physically' away from the worker and ventilation that strategically 'adds' and 'removes' air in the work environment. Local exhaust ventilation usually required. Provide adequate ventilation in warehouse or closed storage area.

Hands

Elbow length PVC gloves. The selection of suitable gloves does not only depend on the material, but also on further marks of quality which vary from manufacturer to manufacturer. Where the chemical is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application. Select gloves tested to a relevant standard (e.g. Europe EN 374, US F739, AS/NZS 2161.1 or national equivalent). For general applications, gloves with a thickness typically greater than 0.35 mm, are recommended.

Eyes

Safety glasses with unperforated side shields may be used where continuous eye protection is desirable; Chemical goggles, whenever there is a danger of the material coming in contact with the eyes; Full face shield (20 cm, 8 in minimum) may be required for supplementary but never for primary protection of eyes. Alternatively a gas mask may replace splash goggles and face shields.

Respiratory

Type AB-P Filter of sufficient capacity. (AS/NZS 1716 & 1715, EN 143:2000 & 149:2001, ANSI Z88 or national equivalent). If risk of overexposure exists, wear approved respirator. Supplied-air type respirator may be required in special circumstances. An approved self contained breathing apparatus (SCBA) may be required in some situations.

Skin/Body

Overalls. P.V.C apron. Barrier cream. Skin cleansing cream. When handling corrosive liquids, wear trousers or overalls outside of boots, to avoid spills entering boots.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Language Code
---
Physical State
Liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
---
Colour
---
Colour Intensity
---
Form
---
Odor
---
Odor Threshold
---
Ph
---
Melting Point
---
Boiling Point
---
Flash Point
---
Freezing Point
---
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
---
Vapor Pressure
---
Vapor Density
---
Relative Density
---
Bulk Density
---
Density
---
Flammability
---
Upper Explosive Limit
---
Lower Explosive Limit
---
Explosive Limits
---
Auto Ignition Temperature
---
Decomposition Temperature
---
Solubility
---
Partition Coefficient
---
Solubility In Water
Immiscible
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
---
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

• Unstable in the presence of incompatible materials. • Product is considered stable. • Hazardous polymerisation will not occur.

Reactivity

See section 7

Hazardous reactions

See section 7

Avoid

See section 7

Incompatible

See section 7

Decomposition

See section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

Toxicity

| guanidine thiocyanate | | | | | | | | | Endpoint | Test Duration (hr) | Species | Value | Source | | | | EC50(ECx) | 48h | Crustacea | 42.4mg/l | 2 | | | EC50 | 72h | Algae or other aquatic plants | 130mg/l | 2 | | | EC50 | 48h | Crustacea | 42.4mg/l | 2 | | | LC50 | 96h | Fish | ~89.1mg/l | 2 |

12.1 Toxicity

Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Aquatic Fate: Biodegradation is a significant transformation process for thiocyanates in natural waters. Thiocyanate is toxic to microorganisms at high concentrations; however, acclimated cultures have increased tolerance to this compound. At concentrations up to 1.42 g/L, thiocyanate is completely degraded within 4 days to ammonia and sulfate ion (SO4-2) by an acclimatized co-culture of two bacteria (Acinetobacter johnsonii and Pseudomonas diminuta).

12.2 Persistence and degradability

For Thiocyanates: Terrestrial Fate: Soil - At near ambient temperatures (approximately 30 C.) it appears that sorption and volatilization are not significant processes for thiocyanate in soil, with thiocyanate losses due primarily to microbial degradation. Thiocyanate is not persistent in soils. Thiocyanate may undergo both aerobic and anaerobic microbial degradation; however, the degradation pathway has not been defined. Saturated soils treated with thiocyanate were found to emit carbonyl sulfide (COS). Microbial degradation is the primary mechanism for thiocyanate disappearance at or below 30 C., with carbonyl sulfide as a possible hydrolysis product. Loss of thiocyanate at higher temperatures (50-60 C.) did not appear to result from microbial degradation. | Ingredient | Persistence: Water/Soil | Persistence: Air | | --- | --- | --- | | | No Data available for all ingredients | No Data available for all ingredients |

12.3 Bioaccumulative potential

| Ingredient | Bioaccumulation | | --- | --- | | | No Data available for all ingredients |

12.4 Mobility in soil

| Ingredient | Mobility | | --- | --- | | | No Data available for all ingredients |

12.5 Results of PBT and vPvB assessment

No data available.

12.6 Endocrine disrupting properties

No data available.

12.7 Other adverse effects

No data available.
13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Recycle wherever possible or consult manufacturer for recycling options. Bury or incinerate residue at an approved site. If it has been contaminated, it may be possible to reclaim the product by filtration, distillation or some other means.

Disposal

Recycle wherever possible or consult manufacturer for recycling options. Consult State Land Waste Authority for disposal. Bury or incinerate residue at an approved site.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

?

Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for TNA Lysis Buffer?

The signal word is danger.

What is the physical form of TNA Lysis Buffer?

TNA Lysis Buffer is a liquid .

What is TNA Lysis Buffer used for?

Laboratory Use

What are the hazard statements for TNA Lysis Buffer?

This substance has 7 hazard statements:

  • H302: Harmful if swallowed.
  • H312: Harmful in contact with skin.
  • H314: Causes severe skin burns and eye damage.
  • H317: May cause an allergic skin reaction.
  • H332: Harmful if inhaled.
  • H401: Toxic to aquatic life.
  • H412: Harmful to aquatic life with long lasting effects.