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Safety Data Sheet EN

Phorbol 12-myristate 13-acetate

CAS 16561-29-8

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Phorbol 12-myristate 13-acetate
Product Code
P8139

Regulatory Identifiers

CAS Number
16561-29-8 Check regulations →
REACH No.
A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

Identified Uses

Laboratory chemicals, Manufacture of substances

Manufacturers & Suppliers

M

Merck Life Science BV/SRL

manufacturer

Brusselsesteenweg 288, B-3090 OVERIJSE

+32 (0)3 899-1301

Emergency Contacts

CHEMTREC

+(32) 28 083237

Anti-poison centre

070 245245

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Acute Tox. Cat. 2 H300
Acute Tox. Cat. 1 H330
Acute Tox. Cat. 1 H310
Skin Corr. Cat. 1B H314
Eye Dam. Cat. 1 H318
Resp. Sens. Cat. 1 H334
Skin Sens. Cat. 1 H317
Carc. Cat. 2 H351

GHS Pictograms

GHS05 - Corrosive

GHS05

GHS06 - Acute toxicity

GHS06

GHS08 - Serious health hazard

GHS08

Hazard Statements

H300 + H310 + H330 Fatal if swallowed, in contact with skin or if inhaled.
H314 Causes severe skin burns and eye damage.
H317 May cause an allergic skin reaction.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H351 Suspected of causing cancer.

Precautionary Statements

P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
12-O-tetradecanoylphorbol 13-monoacetate 16561-29-8 100% Yes

For the full text of the H-Statements mentioned in this Section, see Section 16.

04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

Skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

Eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

Ingestion

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. Do not attempt to neutralise.

Immediate Medical Attention

Immediately call in physician or ophthalmologist. Seek medical advice immediately.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water, Foam, Carbon dioxide (CO2), Dry powder

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Carbon oxides, Combustible, Risk of dust explosion, Development of hazardous combustion gases or vapours possible in the event of fire.

Instructions

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Evacuate the danger area, observe emergency procedures, consult an expert.

Cleanup methods

Take up carefully. Clean up affected area.

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Work under hood. Do not inhale substance/mixture.

Storage

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Full contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: KCL 741 Dermatril® L. Splash contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested: KCL 741 Dermatril® L. Standards compliance: EN374.

Eyes

Tightly fitting safety goggles. Tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Respiratory

Required when dusts are generated. Recommended Filter type: Filter type P3. Standards compliance: DIN EN 143, DIN 14387.

Skin/Body

protective clothing

Environmental

Do not let product enter drains.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Cloud Point
---
Melting Point
50 - 70 °C
Relative Density
No data available
Decomposition Temperature
No data available
Physical State Data
solid
Solubility In Water
practically insoluble
Kinematic Viscosity
No data available
State Under Standard Conditions
---
Colour Intensity
---
Solubility
---
Crystallisation Point
---
Evaporation Rate
No data available
Softening Point
---
Dynamic Viscosity
No data available
Physical State
powder
Form
powder
Solidification Point
---
Odor Threshold
No data available
Metal Corrosion
---
Flammability
No data available
Vapor Pressure
No data available
Density
---
Lower Explosive Limit
No data available
Bulk Density
---
Freezing Point
---
Ph
No data available
Partition Coefficient
log Pow: 6,511
Appearance
powder, colorless
Auto Ignition Temperature
No data available
Boiling Point
698,10 °C at 1.013,3 hPa
Properties Status
---
Explosive Limits
---
Vapor Density
No data available
Colour
colorless
Flash Point
No data available
Molecular Weight
---
Odor
No data available
Voc Content
---
Solubility In Fat
---
Relative Evaporation Rate
---
Upper Explosive Limit
No data available
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Hazardous reactions

Violent reactions possible with: Strong oxidizing agents

Avoid

Exposure to light.

Incompatible

No data available

Decomposition

In the event of fire: see section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Disposal

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
2928
Shipping Name
TOXIC SOLID, CORROSIVE, ORGANIC, N.O.S. (12-O-tetradecanoylphorbol 13-monoacetate)
Transport Class
6.1 (8)
Packing Group
I
ADR

No data available

IMDG

No data available

IATA

No data available

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

Chemical Safety Assessment Not performed

Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Phorbol 12-myristate 13-acetate?

The signal word is danger.

What is the physical form of Phorbol 12-myristate 13-acetate?

Phorbol 12-myristate 13-acetate is a powder appearing as powder, colorless with colorless color. It has no data available odor.

What is Phorbol 12-myristate 13-acetate used for?

Laboratory chemicals, Manufacture of substances

What are the hazard statements for Phorbol 12-myristate 13-acetate?

This substance has 5 hazard statements:

  • H300 + H310 + H330: Fatal if swallowed, in contact with skin or if inhaled.
  • H314: Causes severe skin burns and eye damage.
  • H317: May cause an allergic skin reaction.
  • H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H351: Suspected of causing cancer.

What is the melting point of Phorbol 12-myristate 13-acetate?

The melting point is 50 - 70 °C and the boiling point is 698,10 °C at 1.013,3 hPa.

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