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Safety Data Sheet EN

Hexamethylphosphoramide

CAS 680-31-9

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Hexamethylphosphoramide
Product Code
H11602
Chemical Name
Hexamethylphosphoramide

Regulatory Identifiers

CAS Number
680-31-9 Check regulations →

Identified Uses

Laboratory chemicals, Synthesis of substances

Manufacturers & Suppliers

S

Sigma-Aldrich

manufacturer

3050 Spruce Street, SAINT LOUIS MO 63103, USA

+1 800-325-5832

Emergency Contacts

CHEMTREC

+1-703-527-3887

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Muta. Cat. 1B H340
Carc. Cat. 1B H350

GHS Pictograms

GHS08 - Serious health hazard

GHS08

Hazard Statements

H340 May cause genetic defects.
H350 May cause cancer.

Precautionary Statements

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance

HMPA (Hexamethylphosphoric acid triamide) with a chemical formula of C6H18N3OP.

Chemical Name CAS Number Concentration Hazardous
Hexamethylphosphoric triamide EC: 211-653-8 680-31-9 90 - 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

Skin contact

Wash off with soap and plenty of water. Consult a physician.

Eye contact

Flush eyes with water as a precaution.

Ingestion

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Immediate Medical Attention

No data available

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Firefighter Protection

Wear self-contained breathing apparatus for firefighting if necessary.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Evacuate personnel to safe areas.

Environmental

Prevent further leakage or spillage if safe to do so.

Cleanup methods

Soak up with inert absorbent material

Materials: inert absorbent material

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Avoid inhalation of vapour or mist.

Storage

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Air and moisture sensitive. Handle and store under inert gas.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Handle in accordance with good industrial hygiene and safety practice.

Hands

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Full contact: Material: butyl-rubber, Minimum layer thickness: 0.3 mm, Break through time: 480 min, Material tested: Butoject® (KCL 897 / Aldrich Z677647, Size M). Splash contact: Material: Nitrile rubber, Minimum layer thickness: 0.2 mm, Break through time: 30 min, Material tested: Dermatril® P (KCL 743 / Aldrich Z677388, Size M). Test method: EN374.

Eyes

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Respiratory

Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Skin/Body

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Environmental

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Solubility
No data available
Colour Intensity
---
Bulk Density
---
Crystallisation Point
---
Partition Coefficient
No data available
Relative Evaporation Rate
---
Physical State
liquid
Odor Threshold
No data available
Odor
No data available
Metal Corrosion
---
Relative Density
1.03 g/cm3 at 25 °C (77 °F)
Physical State Data
liquid
Explosive Limits
---
Vapor Density
6.19 - (Air = 1.0)
Flash Point
144 °C (291 °F)
Vapor Pressure
No data available
Voc Content
---
Lower Explosive Limit
No data available
Melting Point
7 °C (45 °F)
Softening Point
---
Upper Explosive Limit
No data available
Solubility In Fat
---
Flammability
No data available
Colour
---
Evaporation Rate
No data available
Properties Status
---
Ph
No data available
State Under Standard Conditions
---
Form
liquid
Density
---
Auto Ignition Temperature
No data available
Appearance
Form: liquid
Kinematic Viscosity
---
Solidification Point
---
Dynamic Viscosity
---
Boiling Point
230 - 232 °C (446 - 450 °F)
Freezing Point
---
Cloud Point
---
Solubility In Water
No data available
Molecular Weight
---
Decomposition Temperature
No data available
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under recommended storage conditions.

Reactivity

No data available

Hazardous reactions

No data available

Avoid

No data available

Incompatible

Strong oxidizing agents, Strong acids

Decomposition

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Oxides of phosphorus, Thermal decomposition may produce toxic fumes of phosphorus oxides and/or phosphine. Other decomposition products - No data available

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

Treatment

Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Disposal

Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
3082
Shipping Name
Environmentally hazardous substance, liquid, n.o.s. (Hexamethylphosphoric triamide)
Transport Class
9
Packing Group
III
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Hexamethylphosphoramide?

The signal word is danger.

What is the physical form of Hexamethylphosphoramide?

Hexamethylphosphoramide is a liquid appearing as form: liquid . It has no data available odor.

What is the solubility of Hexamethylphosphoramide?

No data available

What is Hexamethylphosphoramide used for?

Laboratory chemicals, Synthesis of substances

What are the hazard statements for Hexamethylphosphoramide?

This substance has 2 hazard statements:

  • H340: May cause genetic defects.
  • H350: May cause cancer.

What is the melting point of Hexamethylphosphoramide?

The melting point is 7 °C (45 °F) and the boiling point is 230 - 232 °C (446 - 450 °F).