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CLP Annex I · §3.1

ATE Mixture Calculator

Apply the CLP Annex I additivity formula across the five acute toxicity routes. Enter measured LD50/LC50 values or use the converted point estimate from a hazard category.

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How to read this from the SDS

Pick the route tab that matches the hazard. Oral covers H300–H303, dermal covers H310–H313, inhalation covers H330–H333. For inhalation, pick gas, vapour or dust/mist to match the product's physical form (an aerosol or powder is dust/mist, a solvent is vapour).

Then fill one row per component:

Concentration %
Section 3 Composition / information on ingredients. Use the component's percentage. If it is a range (e.g. 1–5%), enter the highest value for a worst-case result.
ATE / LD50 / LC50
Section 11 Toxicological information. Enter the acute value for the selected route in its units: oral and dermal in mg/kg, inhalation in mg/L (or ppmV for gas). If the SDS states an ATE directly, use that; otherwise use the LD50 / LC50.
or Category
Section 3Section 2 When Section 11 gives no number, leave the value blank and pick the component's Acute Tox. category from its classification (Acute Tox. 4, H302 = Cat 4, and so on). The calculator then substitutes the CLP converted point estimate shown in the reference table below.

Components with no acute-tox value and no category for this route are left out, just as they are in a full classification. Watch the "known fraction": if it is below 10% the result is provisional, because too little of the mixture has data.

Example A component at 0.15% listed as Acute Tox. 4 (H302) with no LD50. Leave the value blank, choose Cat 4. The oral converted estimate of 500 mg/kg is used, giving 0.15 / 500 toward the sum.

Units for this route: mg/kg

Component
Conc. %
ATE / LD50 / LC50
or Cat

Either enter a measured value in the route's units, or pick a CLP hazard category to use the converted point estimate (Annex I Table 3.1.2). Rows with neither are ignored.

Add at least one component with a concentration and an ATE value (or category) to see results.

What the calculator does

All five routes

Oral and dermal in mg/kg, inhalation gas in ppmV, inhalation vapour and dust/mist in mg/L. Each route uses its own converted estimates and cut-off bands.

Measured or converted

Mix measured LD50/LC50 values with CLP converted point estimates from Annex I Table 3.1.2 when only a hazard category is documented for a component.

Verdict with H-code

The result is categorised against the route's cut-off table and shown with the matching H300 / H310 / H330 family code.

CLP Annex I Table 3.1.2 — converted acute toxicity point estimates

When only the hazard category of a component is known, these are the values plugged into the ATE_mix formula. The bottom row shows the upper cut-off for each category when ATE_mix is finally categorised.

Route (unit) Cat 1 Cat 2 Cat 3 Cat 4 Cat 5
Oral (mg/kg)0.551005002500
Dermal (mg/kg)55030011002500
Inhal. gas (ppmV)10100700450020000
Inhal. vapour (mg/L)0.050.531120
Inhal. dust/mist (mg/L)0.0050.050.51.55

Frequently asked questions

What is the formula?
The additivity formula from CLP Annex I §3.1.3.6.1: ATE_mix = 100 / Σ ( Ci / ATEi ), where Ci is the concentration of component i in % w/w and ATEi is its acute toxicity estimate in the route's units. Apply it separately per route.

Why does the calculator say my result is provisional?
If the components with a known ATE add up to less than 10% of the mixture, CLP requires you to handle the unknown fraction explicitly (§3.1.3.6.2). Either source ATE values for the remaining components, or apply the unknown-fraction adjustment in the formula.

Does the result replace a full classification?
No. This is a sanity check for the additivity step only. A full classification also considers bridging principles, the 1% w/w cut-off, mixture-level test data when available, and other hazard classes. NextSDS automates the full workflow.

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Disclaimer: This calculator implements the CLP Annex I §3.1 additivity formula and reference tables for educational and sanity-check purposes. Verify all classifications against the current regulatory text and your supplier-provided SDS data, and consult a qualified chemical safety adviser when in doubt.