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Safety Data Sheet EN

Ergotamine Tartrate

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Ergotamine Tartrate
Product Code
1241506
Chemical Name
Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, [R-(R*,R*)]-2,3-dihydroxy-butanedioate (2:1) (salt)

Regulatory Identifiers

CAS Number
N/A

Identified Uses

Specified quality tests and assay use only.

Uses advised against

Not for use as a drug. Not for administration to humans or animals.

Manufacturers & Suppliers

U. S. Pharmacopeia logo

U. S. Pharmacopeia

manufacturer

12601 Twinbrook Parkway, Rockville, MD 20852-1790, US

301-816-8129

www.usp.org

Emergency Contacts

CHEMTREC within US & Canada

1-800-424-9300

CHEMTREC outside US & Canada

+1 703-527-3887

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Acute Tox. Cat. 4
Muta. Cat. 1
Repr. Cat. 1

GHS Pictograms

GHS07 - Health hazard

GHS07

GHS08 - Serious health hazard

GHS08

Hazard Statements

H302 Harmful if swallowed.
H340 May cause genetic defects.
H360 May damage fertility or the unborn child.

Precautionary Statements

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308 + P313 If exposed or concerned: Get medical advice/attention.
P312 If swallowed: Call a poison center/doctor if you feel unwell.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Ergotamine Tartrate 379-79-3 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Move to fresh air. Call a physician if symptoms develop or persist.

Skin contact

Rinse skin with water/shower. Get medical attention if irritation develops and persists.

Eye contact

Rinse with water. Get medical attention if irritation develops and persists.

Ingestion

IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth.

Immediate Medical Attention

Persons developing serious hypersensitivity (anaphylactic) reactions must receive immediate medical attention.

Medical Treatment

Treatment of ergot alkaloid overdose should be symptomatic and supportive and may include the following: Administer activated charcoal as a slurry. Perform gastric lavage soon after ingestion (within one hour). Protect airway by placement in Trendelenburg and left lateral decubitus position or by endotracheal intubation. For vasoconstriction and hypertension, administer nitroprusside. In patients with evidence of ischemia, also consider intravenous heparin, and with evidence of significant end organ ischemia, also consider intravenous nitroglycerin or phentolamine. For mild peripheral vasoconstriction, treat with nifedipine, and for mild peripheral ischemia, consider prazosin. Surgical or mechanical intervention should only be considered with caution and if gangrene is imminent. For hypotension, infuse isotonic fluid. If hypotension persists, administer dopamine or norepinephrine. For seizures, administer intravenous diazepam or lorazepam. If seizures recur, consider phenobarbital.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Use fire-extinguishing media appropriate for surrounding materials. Water. Foam. Dry chemical or CO2.

Unsuitable media

None known.

Specific hazards

No unusual fire or explosion hazards noted.

Instructions

Use water spray to cool unopened containers. As with all fires, evacuate personnel to a safe area. Use standard firefighting procedures and consider the hazards of other involved materials.

Firefighter Protection

Wear suitable protective equipment. Firefighters should use self-contained breathing equipment and protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Keep unnecessary personnel away. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Ensure adequate ventilation. Avoid inhalation of dust from the spilled material.

Cleanup methods

Sweep up or vacuum up spillage and collect in suitable container for disposal. Clean surface thoroughly to remove residual contamination.

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

As a general rule, when handling USP Reference Standards, avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Clean equipment and work surfaces with suitable detergent or solvent after use. After removing gloves, wash hands and other exposed skin thoroughly. Use of a designated area is recommended for handling of potent materials.

Storage

Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.

Hygiene

After removing gloves, wash hands and other exposed skin thoroughly.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Odor
Odorless.
Solubility In Fat
---
Physical State
Solid.
Evaporation Rate
Not available.
Upper Explosive Limit
Not available.
Solidification Point
---
State Under Standard Conditions
---
Ph
Not available.
Crystallisation Point
---
Relative Evaporation Rate
---
Lower Explosive Limit
Not available.
Kinematic Viscosity
---
Odor Threshold
Not available.
Properties Status
---
Dynamic Viscosity
---
Boiling Point
Not available.
Density
---
Physical State Data
solid
Flammability
Not applicable.
Voc Content
---
Freezing Point
---
Appearance
Colorless crystals, or white to yellowish-white crystalline powder.
Melting Point
397.4 °F (203 °C) (decomposes); also reported as 180 - 187 °C.
Vapor Density
Not available.
Colour
---
Molecular Weight
1313.41
Cloud Point
---
Solubility In Water
Slightly soluble.
Solubility
---
Softening Point
---
Relative Density
Not available.
Partition Coefficient
2.5 (at 20 °C)
Metal Corrosion
---
Explosive Limits
---
Decomposition Temperature
Not available.
Flash Point
> 680.00 °F (> 360.00 °C) (hot plate)
Auto Ignition Temperature
788 °F (420 °C) BAM (fluidized dust)
Form
Powder.
Vapor Pressure
< 0.0000001 kPa at 25 °C
Colour Intensity
---
Bulk Density
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable at normal conditions.

Reactivity

No reactivity hazards known.

Hazardous reactions

No dangerous reaction known under conditions of normal use.

Avoid

None known.

Incompatible

Strong oxidizing agents.

Decomposition

NOx. Irritating and/or toxic fumes or gases. Emits toxic fumes under fire conditions.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for Ergotamine Tartrate?

The signal word is danger.

What is the physical form of Ergotamine Tartrate?

Ergotamine Tartrate is a solid. appearing as colorless crystals, or white to yellowish-white crystalline powder. . It has odorless. odor.

What is Ergotamine Tartrate used for?

Specified quality tests and assay use only.

What are the hazard statements for Ergotamine Tartrate?

This substance has 3 hazard statements:

  • H302: Harmful if swallowed.
  • H340: May cause genetic defects.
  • H360: May damage fertility or the unborn child.

What is the melting point of Ergotamine Tartrate?

The melting point is 397.4 °F (203 °C) (decomposes); also reported as 180 - 187 °C. and the boiling point is Not available..