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Safety Data Sheet EN

β-Estradiol

CAS 50-28-2

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
β-Estradiol
Product Code
E2758

Regulatory Identifiers

CAS Number
50-28-2 Check regulations →
REACH No.
A registration number is not available for this substance as the substance or its uses are exempted from registration or the annual tonnage does not require a registration.

Identified Uses

Laboratory chemicals, Manufacture of substances

Manufacturers & Suppliers

S

Sigma-Aldrich Chemie GmbH

manufacturer

Eschenstrasse 5, D-82024 TAUFKIRCHEN

+49 (0)89 6513-1130

Emergency Contacts

CHEMTREC Deutschland

0800 181 7059

CHEMTREC weltweit

+49 (0)696 43508409

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Carc. Cat. 2 H351
Repr. Cat. 1A H360FD
Lact. H362
Aquatic Acute Cat. 1 H400
Aquatic Chronic Cat. 1 H410

GHS Pictograms

GHS08 - Serious health hazard

GHS08

GHS09 - Environmental hazard

GHS09

Hazard Statements

H351 Suspected of causing cancer.
H360FD May damage fertility. May damage the unborn child.
H362 May cause harm to breast-fed children.
H410 Very toxic to aquatic life with long lasting effects.

Precautionary Statements

P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust.
P263 Avoid contact during pregnancy and while nursing.
P264 Wash skin thoroughly after handling.
P273 Avoid release to the environment.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
estradiol EC: 200-023-8 50-28-2 100% Yes
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

After inhalation: fresh air. Call in physician.

Skin contact

Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

Eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

Ingestion

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards

Carbon oxides. Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.

Instructions

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Firefighter Protection

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental

Do not let product enter drains.

Cleanup methods

Take up carefully. Clean up affected area.

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Work under hood. Do not inhale substance/mixture.

Storage

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.

Hygiene

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Hands

Splash contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested:KCL 741 Dermatril® L. Full contact: Material: Nitrile rubber, Minimum layer thickness: 0,11 mm, Break through time: 480 min, Material tested:KCL 741 Dermatril® L.

Eyes

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Respiratory

required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3. The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Skin/Body

protective clothing

Environmental

Do not let product enter drains.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Upper Explosive Limit
---
Physical State
powder
Appearance
---
Cloud Point
---
Ph
No data available
Density
1,2 g/cm³ at 20 °C - OECD Test Guideline 109
Voc Content
---
Solubility In Fat
---
Flammability
No data available
Auto Ignition Temperature
No data available
Boiling Point
413,45 °C - OECD Test Guideline 103
Solidification Point
---
Odor Threshold
---
Partition Coefficient
log Pow: 4,01 - (calculated) - Potential bioaccumulation, (Lit.)
Melting Point
176 - 180 °C - lit.
Form
---
Freezing Point
---
Solubility
---
Evaporation Rate
---
Metal Corrosion
---
Odor
odourless
Softening Point
---
Molecular Weight
---
Explosive Limits
---
Dynamic Viscosity
No data available
Vapor Density
---
Solubility In Water
0,0015 g/l at 20 °C - OECD Test Guideline 105- slightly soluble
Properties Status
---
Vapor Pressure
< 0,1 hPa at 20 °C - OECD Test Guideline 104
Kinematic Viscosity
No data available
Relative Density
1,2 at 20 °C - OECD Test Guideline 109
Physical State Data
solid
Bulk Density
---
Lower Explosive Limit
---
State Under Standard Conditions
---
Decomposition Temperature
No data available
Relative Evaporation Rate
---
Crystallisation Point
---
Flash Point
Not applicable
Colour Intensity
---
Colour
whiteoff-white
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Hazardous reactions

Violent reactions possible with: Strong oxidizing agents

Avoid

no information available

Incompatible

No data available

Decomposition

In the event of fire: see section 5

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
3077
Shipping Name
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (estradiol)
Transport Class
9
Packing Group
III
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What is the hazard signal word for β-Estradiol?

The signal word is danger.

What is the physical form of β-Estradiol?

β-Estradiol is a powder with whiteoff-white color. It has odourless odor.

What is β-Estradiol used for?

Laboratory chemicals, Manufacture of substances

What are the hazard statements for β-Estradiol?

This substance has 4 hazard statements:

  • H351: Suspected of causing cancer.
  • H360FD: May damage fertility. May damage the unborn child.
  • H362: May cause harm to breast-fed children.
  • H410: Very toxic to aquatic life with long lasting effects.

What is the melting point of β-Estradiol?

The melting point is 176 - 180 °C - lit. and the boiling point is 413,45 °C - OECD Test Guideline 103.