Chemical Product Identification & Regulatory Data
Official chemical identifiers, CAS numbers, and regulatory compliance information
Basic Product Information
Regulatory Identifiers
Chemical Abstracts Service registry number - unique identifier for chemical substances
Uses Information
Overview
R437A (Isceon M049 Plus) is a colourless clear compressed liquefied gas with a slight ether-like odour. substance commonly used refrigerant, for professional users only the use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere developing. before starting consider control of exposure by mechanical ventilation..
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GHS Hazard Classification & Safety Warnings
Globally Harmonized System (GHS) hazard pictograms, signal words, and safety classifications
Classification Status
Signal Word
Hazard Classifications
GHS Hazard Pictograms & Safety Symbols
GHS04
GHS (Globally Harmonized System) pictograms indicate specific chemical hazard categories and safety precautions
Hazard Statements
- H280: Contains gas under pressure; may explode if heated.
Precautionary Statements
- P101: If medical advice is needed, have product container or label at hand.
- P102: Keep out of reach of children.
- P103: Read carefully and follow all instructions.
- P410+P403: Protect from sunlight. Store in a well-ventilated place.
Chemical Manufacturers & Supply Chain
Authorized suppliers, manufacturers, and distribution network information
A-Gas (UK) Ltd
manufacturer
Banyard Road, Portbury West Bristol BS20 7XH United Kingdom
GB
+44 (0) 1275 376600
+44 (0) 1275 376601
24/7 Emergency Response & Poison Control
Critical emergency contact numbers for chemical spills, exposure incidents, and medical emergencies
A-Gas (UK) Ltd
+44 (0) 1275 376600
GB
CHEMWATCH EMERGENCY RESPONSE (24/7)
+44 20 3901 3542
GB
CHEMWATCH EMERGENCY RESPONSE (24/7)
+44 808 164 9592
GB
Chemical Composition & Hazardous Ingredients
Detailed component analysis, concentration ranges, and hazardous substance identification
Product Type
mixtureChemical Components & Hazardous Substances
| Chemical Name | CAS Number | Concentration | Hazardous |
|---|---|---|---|
| 1,1,1,2- tetrafluoroethane EC: 212-377-0 | 811-97-2 | 60% | ⚠️ Hazardous |
| pentafluoroethane EC: 206-557-8 | 354-33-6 | 10-30% | ⚠️ Hazardous |
| butane EC: 203-448-7 | 106-97-8 | 10% | ⚠️ Hazardous |
| n-pentane EC: 203-692-4 | 109-66-0 | 10% | ⚠️ Hazardous |
Emergency First Aid Measures
Critical first aid procedures for chemical exposure incidents and medical emergencies
🫁 Inhalation Exposure
NOTE: Personal Protective Equipment (PPE), including positive pressure self-contained breathing apparatus may be required to assure the safety of the rescuer. Prostheses such as false teeth, which may block the airway, should be removed, where possible, prior to initiating first aid procedures. If the patient is not breathing spontaneously, administer rescue breathing. If the patient does not have a pulse, administer CPR. If medical oxygen and appropriately trained personnel are available, administer 100% oxygen. Summon an emergency ambulance. If an ambulance is not available, contact a physician, hospital, or Poison Control Centre for further instruction. Keep the patient warm, comfortable and at rest while awaiting medical care. MONITOR THE BREATHING AND PULSE, CONTINUOUSLY. Administer rescue breathing (preferably with a demand-valve resuscitator, bag-valve mask-device, or pocket mask as trained) or CPR if necessary.
Symptoms:
Following exposure to gas, remove the patient from the gas source or contaminated area.
🖐️ Skin Contact
If skin contact occurs: Immediately remove all contaminated clothing, including footwear. Flush skin and hair with running water (and soap if available). Seek medical attention in event of irritation. In case of cold burns (frost-bite): Move casualty into warmth before thawing the affected part; if feet are affected carry if possible Bathe the affected area immediately in luke-warm water (not more than 35 deg C) for 10 to 15 minutes, immersing if possible and without rubbing DO NOT apply hot water or radiant heat. Apply a clean, dry, light dressing of 'fluffed-up' dry gauze bandage If a limb is involved, raise and support this to reduce swelling If an adult is involved and where intense pain occurs provide pain killers such as paracetomol.
Symptoms:
Subsequent blackening of the exposed tissue indicates potential of necrosis, which may require amputation.
👁️ Eye Contact
Immediately flush eyes with lukewarm water for at least 15 minutes while holding eyelids open. Remove contact lenses if present and easy to do.
Symptoms:
Even when no pain persists and vision is good, a doctor should examine the eye as delayed damage may occur.
🍽️ Ingestion/Swallowing
Avoid giving milk or oils. Avoid giving alcohol.
Symptoms:
Not considered a normal route of entry.
🚨 Immediate Medical Attention Required
Maintain an open airway and assist ventilation if necessary. Treat coma and arrhythmias if they occur. Avoid (adrenaline) epinephrine or other sympathomimetic amines that may precipitate ventricular arrhythmias. Tachyarrhythmias caused by increased myocardial sensitisation may be treated with propranolol, 1-2 mg IV or esmolol 25-100 microgm/kg/min IV. Monitor the ECG for 4-6 hours.
Medical Treatment
Administer activated charcoal, if available. DO NOT induce vomiting because of rapid absorption and the risk of abrupt onset CNS depression. Administer activated charcoal, although the efficacy of charcoal is unknown. Perform gastric lavage only if the ingestion was very large and recent (less than 30 minutes).
Fire Fighting Measures & Emergency Response
Fire suppression methods, extinguishing media, and firefighting safety procedures
✅ Suitable Extinguishing Media
Use extinguishing agent suitable for type of surrounding fire. Cool cylinder.
❌ Unsuitable Extinguishing Media
DO NOT direct water at source of leak or venting safety devices as icing may occur.
⚠️ Specific Fire Hazards
Containers may explode when heated - Ruptured cylinders may rocket. Fire exposed containers may vent contents through pressure relief devices. High concentrations of gas may cause asphyxiation without warning. May decompose explosively when heated or involved in fire. Contact with gas may cause burns, severe injury and/or frostbite.
🔥 Fire Fighting Instructions
Alert Fire Brigade and tell them location and nature of hazard. Wear breathing apparatus and protective gloves. Fight fire from a safe distance, with adequate cover. Use water delivered as a fine spray to control fire and cool adjacent area.
Accidental Release Measures & Spill Response
Emergency spill cleanup procedures, containment methods, and environmental protection
💧 Small Spill Procedures
Avoid breathing vapour and any contact with liquid or gas.
🌊 Large Spill Procedures
DO NOT exert excessive pressure on valve; DO NOT attempt to operate damaged valve.
🌍 Environmental Precautions
Prevent by any means available, spillage from entering drains and water-courses.
Related Chemical Substances & Alternative Products
Similar chemicals with comparable safety profiles and industrial applications
Technical Specifications & Material Properties
Physical state, chemical properties, melting point, boiling point, and material characteristics
Safe Handling & Storage Procedures
Industrial handling precautions, storage conditions, and workplace safety requirements
⚠️ Handling Precautions
• Consider use in closed pressurised systems, fitted with temperature, pressure and safety relief valves which are vented for safe dispersal.
• Use only properly specified equipment which is suitable for this product, its supply pressure and temperature.
• The tubing network design connecting gas cylinders to the delivery system should include appropriate pressure indicators and vacuum or suction lines.
• Fully-welded types of pressure gauges, where the bourdon tube sensing element is welded to the gauge body, are recommended.
• Before connecting gas cylinders, ensure manifold is mechanically secure and does not containing another gas.
• DO NOT transfer gas from one cylinder to another.
Exposure Controls & Personal Protective Equipment (PPE)
Occupational exposure limits, engineering controls, and required safety equipment
🏭 Engineering Controls
Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed engineering controls can be highly effective in protecting workers and will typically be independent of worker interactions to provide this high level of protection. The basic types of engineering controls are: Process controls which involve changing the way a job activity or process is done to reduce the risk. Enclosure and/or isolation of emission source which keeps a selected hazard "physically" away from the worker and ventilation that strategically "adds" and "removes" air in the work environment.
🧤 Hand Protection
When handling sealed and suitably insulated cylinders wear cloth or leather gloves. · Insulated gloves: NOTE: Insulated gloves should be loose fitting so that may be removed quickly if liquid is spilled upon them. Insulated gloves are not made to permit hands to be placed in the liquid; they provide only short-term protection from accidental contact with the liquid.
👁️ Eye Protection
Chemical goggles. Full face shield may be required for supplementary but never for primary protection of eyes. Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing the wearing of lenses or restrictions on use, should be created for each workplace or task.
😷 Respiratory Protection
Type AX Filter of sufficient capacity. (AS/NZS 1716 & 1715, EN 143:2000 & 149:2001, ANSI Z88 or national equivalent)
🦺 Skin/Body Protection
See Hand protection below
🌍 Environmental Exposure Controls
See section 12
Chemical Stability & Reactivity Data
Chemical stability, hazardous reactions, and incompatible materials information
✅ Chemical Stability
Unstable in the presence of incompatible materials. Product is considered stable. Hazardous polymerisation will not occur.
Ecological Information & Environmental Impact
Environmental toxicity, biodegradation, bioaccumulation, and ecological effects data
🌱 Toxicity
| R437A (Isceon M049 Plus) | Endpoint | Test Duration (hr) | Species | Value | Source |
|---|---|---|---|---|---|
| Not Available | Not Available | Not Available | Not Available | Not Available | |
| 1,1,1,2-tetrafluoroethane | Endpoint | Test Duration (hr) | Species | Value | Source |
| EC50 | 48h | Crustacea | 980mg/L | 5 | |
| EC50 | 72h | Algae or other aquatic plants | >114mg/l | 2 | |
| EC50 | 96h | Algae or other aquatic plants | 142mg/l | 2 | |
| NOEC(ECx) | 72h | Algae or other aquatic plants | ~13.2mg/l | 2 | |
| LC50 | 96h | Fish | 450mg/l | 2 | |
| pentafluoroethane | Endpoint | Test Duration (hr) | Species | Value | Source |
| EC50 | 48h | Crustacea | >97.9mg/l | 2 | |
| EC50 | 72h | Algae or other aquatic plants | >114mg/l | 2 | |
| EC50 | 96h | Algae or other aquatic plants | 142mg/l | 2 | |
| NOEC(ECx) | 96h | Fish | 10mg/l | 2 | |
| LC50 | 96h | Fish | >81.8mg/l | 2 | |
| butane | Endpoint | Test Duration (hr) | Species | Value | Source |
| EC50(ECx) | 96h | Algae or other aquatic plants | 7.71mg/l | 2 | |
| EC50 | 96h | Algae or other aquatic plants | 7.71mg/l | 2 | |
| LC50 | 96h | Fish | 24.11mg/l | 2 | |
| n-pentane | Endpoint | Test Duration (hr) | Species | Value | Source |
| EC50 | 48h | Crustacea | 2.3mg/l | 2 | |
| EC50 | 72h | Algae or other aquatic plants | 1.26mg/l | 2 | |
| EC50(ECx) | 8h | Algae or other aquatic plants | 1mg/l | 1 | |
| LC50 | 96h | Fish | 4.26mg/l | 2 | |
| Legend: | Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity 4. US EPA, Ecotox database - Aquatic Toxicity Data 5. ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) - Bioconcentration Data 7. METI (Japan) - Bioconcentration Data 8. Vendor Data | ||||
🌱 Persistence and degradability
| Ingredient | Persistence: Water/Soil Persistence: Air | |
|---|---|---|
| 1,1,1,2-tetrafluoroethane | HIGH | HIGH |
| pentafluoroethane | HIGH | HIGH |
| butane | LOW | LOW |
| n-pentane | LOW | LOW |
🌱 Bioaccumulative potential
| Ingredient | Bioaccumulation |
|---|---|
| 1,1,1,2-tetrafluoroethane | LOW (LogKOW = 1.68) |
| pentafluoroethane | LOW (LogKOW = 1.55) |
| butane | LOW (LogKOW = 2.89) |
| n-pentane | LOW (BCF = 2.35) |
🌱 Mobility in soil
| Ingredient | Mobility |
|---|---|
| 1,1,1,2-tetrafluoroethane | LOW (Log KOC = 96.63) |
| pentafluoroethane | LOW (Log KOC = 154.4) |
| butane | LOW (Log KOC = 43.79) |
| n-pentane | LOW (Log KOC = 80.77) |
🌱 Results of PBT and vPvB assessment
| P | B | T | |
|---|---|---|---|
| Relevant available data | Not Available | Not Available | Not Available |
| PBT | ☒ | ☒ | ☒ |
| vPvB | ☒ | × ☒ | × ☒ |
🌱 Endocrine disrupting properties
🌱 Other adverse effects
Waste Disposal & Treatment Methods
Waste disposal procedures, treatment methods, and regulatory compliance requirements
♻️ Waste Treatment Methods
Not Available
🗂️ Product Disposal Recommendations
Evaporate residue at an approved site. Return empty containers to supplier. If containers are marked non-returnable establish means of disposal with manufacturer prior to purchase. · Ensure damaged or non-returnable cylinders are gas-free before disposal.
Transportation & Shipping Information
UN numbers, shipping names, transport classes, and regulatory transport requirements
🏷️ UN Number
1078
📦 Proper Shipping Name
REFRIGERANT GAS, N.O.S., such as mixture F1, mixture F2 or mixture F3 (contains pentafluoroethane and 1,1,1,2-tetrafluoroethane)
⚠️ Transport Hazard Class
2.2
📋 Packing Group
Not Applicable
🚛 ADR Transport Precautions
274 582 662
🚢 IMDG Maritime Transport Precautions
F-C , S-V
Regulatory Information & Compliance
Chemical regulations, safety assessments, and regulatory compliance status
📋 Regulatory Summary
This safety data sheet is in compliance with the following EU legislation and its adaptations - as far as applicable - : Directives 98/24/EC, - 92/85/EEC, - 94/33/EC, - 2008/98/EC, - 2010/75/EU; Commission Regulation (EU) 2020/878; Regulation (EC) No 1272/2008 as updated through ATPs.
❌ Chemical Safety Assessment
No chemical safety assessment has been performed for this substance.
ℹ️ Additional Regulatory Information
Classification of the preparation and its individual components has drawn on official and authoritative sources using available literature references.
Chemical Safety FAQ & Common Questions
Most frequently asked questions about safety, handling, storage, and regulatory compliance
What is the hazard signal word for R437A (Isceon M049 Plus)?
The signal word for this substance is "warning".
What is the physical form of R437A (Isceon M049 Plus)?
R437A (Isceon M049 Plus) is a liquified gas appearing as colourless clear compressed liquefied gas with a slight ether-like odour. . It has not available odor.
What is R437A (Isceon M049 Plus) used for?
Refrigerant, for professional users only The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere developing. Before starting consider control of exposure by mechanical ventilation.
What are the hazard statements for R437A (Isceon M049 Plus)?
This substance has 1 hazard statements: H280: Contains gas under pressure; may explode if heated.
What is the melting point of R437A (Isceon M049 Plus)?
The melting point is Not Available and the boiling point is -32 - - 29.