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Safety Data Sheet EN

Acetonitrile

CAS 75-05-8

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Acetonitrile
Product Code
A955-1, A955-4, A955-212, A955-500; A955RS-200; XXA955RS50; XXA955100ML; XXA955RS200ASME; A955SS-50; NC1440565; NC1615283; NC1725002; NC1766658; NC2050437; NC0960203; A9554-PN; A955RS-28; NC3814857
Synonyms
AN; Methyl cyanide; Ethanenitrile

Regulatory Identifiers

CAS Number
75-05-8 Check regulations →

Identified Uses

Laboratory chemicals.

Manufacturers & Suppliers

F

Fisher Scientific Company

manufacturer

One Reagent Lane, Fair Lawn, NJ 07410

(201) 796-7100

Emergency Contacts

CHEMTREC®

800-424-9300

CHEMTREC®

001-703-527-3887

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Flammable liquids Cat. 2
Acute oral toxicity Cat. 4
Acute dermal toxicity Cat. 4
Acute Inhalation Toxicity - Vapors Cat. 4
Serious Eye Damage/Eye Irritation Cat. 2

GHS Pictograms

GHS02 - Flammable

GHS02

GHS07 - Health hazard

GHS07

Hazard Statements

H225 Highly flammable liquid and vapor
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
H319 Causes serious eye irritation

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking
P233 Keep container tightly closed
P240 Ground and bond container and receiving equipment
P241 Use explosion-proof electrical/ventilating/lighting equipment
P242 Use non-sparking tools
P243 Take action to prevent static discharges
P260 Do not breathe dust/fume/gas/mist/vapors/spray
P264 Wash face, hands and any exposed skin thoroughly after handling
P270 Do not eat, drink or smoke when using this product
P271 Use only outdoors or in a well-ventilated area
P280 Wear protective gloves/protective clothing/eye protection/face protection
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower
P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P312 Call a POISON CENTER or doctor if you feel unwell
P314 Get medical attention/advice if you feel unwell
P330 Rinse mouth
P337 + P313 If eye irritation persists: Get medical advice/attention
P362 + P364 Take off contaminated clothing and wash before reuse
P370 + P378 In case of fire: Use CO2, dry chemical, or foam to extinguish
P403 + P235 Store in a well-ventilated place. Keep cool
P501 Dispose of contents/container to an approved waste disposal plant

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Acetonitrile 75-05-8 95% No

Revision Date 18-Dec-2025

04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Remove to fresh air. If breathing is irregular or stopped, administer artificial respiration.

Symptoms: Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting.

Skin contact

Wash off immediately with plenty of water for at least 15 minutes.

Eye contact

Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

Ingestion

Do NOT induce vomiting. Call a physician or poison control center immediately.

Immediate Medical Attention

Immediate medical attention is required.

Medical Treatment

Treat symptomatically

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

Water spray. CO₂, dry chemical, dry sand, alcohol-resistant foam. Water mist may be used to cool closed containers.

Unsuitable media

Water may be ineffective, Do not use a solid water stream as it may scatter and spread fire

Specific hazards

Flammable. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Containers may explode when heated. Vapors may form explosive mixtures with air.

Instructions

Water mist may be used to cool closed containers.

Firefighter Protection

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak.

Environmental

Should not be released into the environment.

Cleanup methods

Soak up with inert absorbent material.

Materials: inert absorbent material

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Wear personal protective equipment/face protection. Ensure adequate ventilation. Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges. Do not get in eyes, on skin, or on clothing. Do not breathe mist/vapors/spray. Use spark-proof tools and explosion-proof equipment. Use only non-sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded.

Storage

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat, sparks and flame. Flammables area.

Hygiene

Do not get in eyes, on skin, or on clothing. Do not breathe mist/vapors/spray.

Fire prevention

Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges. Use spark-proof tools and explosion-proof equipment. Use only non-sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Use explosion-proof electrical/ventilating/lighting equipment.

Hands

Wear appropriate protective gloves

Eyes

Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.

Respiratory

Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended Filter type: low boiling organic solvent. Type AX. Brown. conforming to EN371.

Skin/Body

Wear appropriate protective clothing to prevent skin exposure.

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Voc Content
---
Relative Evaporation Rate
---
Relative Density
0.781
Ph
No information available
Flammability
Highly flammable
Physical State
Liquid
Physical State Data
liquid
Solubility In Water
Miscible
Metal Corrosion
---
Freezing Point
---
Vapor Pressure
97 mbar @ 20 °C
Colour Intensity
---
Bulk Density
Not applicable
Vapor Density
1.42
Odor
aromatic
Crystallisation Point
---
Flash Point
12.8 °C / 55 °F
Softening Point
No data available
Kinematic Viscosity
---
Density
---
Explosive Limits
---
Solidification Point
---
Lower Explosive Limit
3 vol %
State Under Standard Conditions
---
Properties Status
---
Melting Point
-46 °C / -50.8 °F
Evaporation Rate
5.79 - (Butyl Acetate = 1.0)
Cloud Point
---
Colour
Colorless
Dynamic Viscosity
0.36 cP at 20 °C
Decomposition Temperature
No data available
Solubility
---
Boiling Point
81 - 82 °C / 177.8 - 179.6 °F
Form
---
Upper Explosive Limit
16 vol %
Molecular Weight
41.05
Odor Threshold
170 ppm
Appearance
Colorless
Solubility In Fat
---
Partition Coefficient
-0.34
Auto Ignition Temperature
525 °C / 977 °F
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

Stable under normal conditions.

Reactivity

None known, based on information available

Hazardous reactions

None under normal processing.

Avoid

Incompatible products. Keep away from open flames, hot surfaces and sources of ignition. Exposure to moisture.

Incompatible

Strong oxidizing agents, Strong acids, Reducing Agent, Bases

Decomposition

Hydrogen cyanide (hydrocyanic acid), Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO₂)

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
UN1648
Shipping Name
ACETONITRILE
Transport Class
3
Packing Group
II
15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What other names is Acetonitrile known by?

Acetonitrile is also known as: AN; Methyl cyanide; Ethanenitrile

What is the hazard signal word for Acetonitrile?

The signal word is danger.

What is the physical form of Acetonitrile?

Acetonitrile is a liquid appearing as colorless with colorless color. It has aromatic odor.

What is Acetonitrile used for?

Laboratory chemicals.

What are the hazard statements for Acetonitrile?

This substance has 3 hazard statements:

  • H225: Highly flammable liquid and vapor
  • H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled
  • H319: Causes serious eye irritation

What is the melting point of Acetonitrile?

The melting point is -46 °C / -50.8 °F and the boiling point is 81 - 82 °C / 177.8 - 179.6 °F.