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Safety Data Sheet EN

Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments

CAS 75-05-8

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01

Identification

Product identifiers, regulatory numbers, and supplier information

Product Information

Product Name
Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments
Product Code
83640
Chemical Name
Acetonitrile
Synonyms
Cyanomethane, Ethanenitrile, Ethanoic acid nitrile, Methyl cyanide

Regulatory Identifiers

CAS Number
75-05-8 Check regulations →
REACH No.
01-2119471307-38-XXXX

Identified Uses

General chemical reagent

Uses advised against

The product, as such or as a component of a mixture, is not intended to be used by consumers (as defined by the REACH Regulation).

Manufacturers & Suppliers

V

VWR International B.V.

national supplier

Orlyplein 85, 1043 DS Amsterdam, Nederland

+31 20 480 8410

Emergency Contacts

National Poisons Information Center (NVIC)

030 2748888

02

Hazard Identification

GHS classification, signal word, pictograms, and hazard statements

Classified danger

Hazard Classifications

Flam. Liq. Cat. 2 H225
Acute Tox. Cat. 4 H302 + H312 + H332
Eye Irrit. Cat. 2 H319

GHS Pictograms

GHS02 - Flammable

GHS02

GHS07 - Health hazard

GHS07

Hazard Statements

H225 Highly flammable liquid and vapour.
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled.
H319 Causes serious eye irritation.

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P312 Call a POISON CENTER/doctor if you feel unwell.
P337 + P313 If eye irritation persists: Get medical advice/attention.

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03

Composition / Information on Ingredients

Chemical components, concentration ranges, and hazardous substance identification

Type substance
Chemical Name CAS Number Concentration Hazardous
Acetonitrile EC: 200-835-2 75-05-8 --- No
04

First Aid Measures

Emergency procedures for chemical exposure incidents

Inhalation

Remove casualty to fresh air and keep warm and at rest. In case of respiratory tract irritation, consult a physician. When in doubt or if symptoms are observed, get medical advice.

Symptoms: Cough. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Skin contact

Take off immediately all contaminated clothing. Wash off any skin contamination immediately.

Symptoms: Erythema (Redness). Oedema.

Eye contact

Rinse immediately carefully and thoroughly with eye-bath or water. Remove contact lenses, if present and easy to do. Continue rinsing. Consult an ophthalmologist. Call a POISON CENTER or doctor/physician.

Symptoms: Irritation Conjunctival redness.

Ingestion

Rinse mouth thoroughly with water. Immediately call a POISON CENTRE/doctor. Never give anything by mouth to an unconscious person or a person with cramps.

Symptoms: Vomiting. Irritation.

Immediate Medical Attention

Upon absorption and metabolism acetonitrile immediately begins a slow release of cyanide, which can continue for several hours. The toxic effects and associated clinical signs of cyanide poisoning may therefore be delayed.

Medical Treatment

If the patient is conscious and breathing normally, administration of oxygen is the only treatment necessary. One ampoule of dicobalt edetate (300 mg) diluted in 20 ml glucose solution is given by slow intravenous injection, being careful to avoid extravasation. Treatment may be repeated if there is an inadequate response to the initial injection.

05

Firefighting Measures

Extinguishing media, specific hazards, and firefighter protection

Suitable media

ABC-powder, Carbon dioxide (CO2), Dry sand, Nitrogen

Unsuitable media

In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. Use dry extinguishing powder to extinguish.

Specific hazards

Flammable liquids. Risk of ignition. Vapour can form explosive mixtures with air. Causes eye irritation. Vapours can travel considerable distances to a source of ignition where they can ignite, flash back, or explode. Closed containers may burst when pressure and temperature rise.

Instructions

In case of fire and/or explosion do not breathe fumes. Co-ordinate fire-fighting measures to the fire surroundings.

Firefighter Protection

Wear a self-contained breathing apparatus and chemical protective clothing. Use water spray jet to protect personnel and to cool endangered containers.

06

Accidental Release Measures

Spill cleanup procedures, containment, and environmental protection

Emergency procedures

Wear personal protection equipment (refer to section 8). Avoid contact with eyes and skin. Avoid breathing dust/mist. Provide adequate ventilation. Keep away from sources of heat (e.g. hot surfaces), sparks and open flames. Remove victim out of the danger area.

Small spill

Absorb with liquid-binding material (sand, diatomaceous earth, acid- or universal binding agents).

Large spill

Take up mechanically.

Environmental

Cover drains. Do not allow to enter into surface water or drains. Collect contaminated fire extinguishing water separately.

Cleanup methods

Clear spills immediately. Collect in closed and suitable containers for disposal.

Materials: sand, diatomaceous earth, acid- or universal binding agents

Related Products

Similar products with comparable safety profiles

07

Handling and Storage

Safe handling precautions, storage conditions, and workplace requirements

Handling

Use personal protective equipment as required. Use only in well-ventilated areas. Avoid breathing vapours. Avoid contact with eyes and skin.

Storage

Keep container tightly closed and in a well-ventilated place. Keep away from sources of heat (e.g. hot surfaces), sparks and open flames. Protect from sunlight.

Hygiene

Wash hands before breaks and after work. Avoid contact with eyes and skin. When using do not eat, drink or smoke. Provide eye shower and label its location conspicuously.

Fire prevention

Usual measures for fire prevention. Have fire-extinguishers in readiness before opening containers. Take precautionary measures against static discharges.

08

Exposure Controls / PPE

Occupational exposure limits, engineering controls, and protective equipment

Engineering

Technical measures and the application of suitable work processes have priority over personal protection equipment. If handled uncovered, arrangements with local exhaust ventilation have to be used.

Hands

When handling with chemical substances, protective gloves must be worn with the CE-label including the four control digits. Recommended glove articles DIN-/EN-Norms EN ISO 374. In the case of wanting to use the gloves again, clean them before taking off and air them well. By short-term hand contact: Suitable material: NBR (Nitrile rubber), Thickness of the glove material: 0,425 mm, Breakthrough time: 14 min, Recommended glove articles: VWR 112-0971. By long-term hand contact: Suitable material: Butyl caoutchouc (butyl rubber), Thickness of the glove material: 0,30 mm, Breakthrough time: >480 min, Recommended glove articles: VWR 112-3779

Eyes

Eye glasses with side protection DIN-/EN-Norms EN 166. Recommendation: VWR 111-0432

Respiratory

Respiratory protection necessary at: aerosol or mist formation. Suitable respiratory protection apparatus: Full-/half-/quarter-face masks (EN 136/140). Recommendation: VWR 111-0206. Suitable material: ABEK2P3. Recommendation: VWR 111-0059

Skin/Body

Wear suitable protective clothing. When handling with chemical substances, protective clothing with CE-labels including the four control digits must be worn.

Environmental

no data available

09

Physical and Chemical Properties

Appearance, physical state, melting point, boiling point, and material characteristics

Physical State
liquid
Physical State Data
liquid
State Under Standard Conditions
---
Appearance
---
Colour
colourless
Colour Intensity
---
Form
---
Odor
ether-like
Odor Threshold
---
Ph
no data available
Melting Point
-45.7 °C
Boiling Point
81.6 °C (1013 hPa)
Flash Point
2 °C (closed cup)
Freezing Point
-45.7 °C
Softening Point
---
Solidification Point
---
Cloud Point
---
Crystallisation Point
---
Relative Evaporation Rate
---
Evaporation Rate
---
Vapor Pressure
97 hPa (20 °C)
Vapor Density
---
Relative Density
---
Bulk Density
---
Density
0.7820 g/cm³ (20 °C)
Flammability
Highly flammable liquid and vapour.
Upper Explosive Limit
17 % (v/v)
Lower Explosive Limit
3 % (v/v)
Explosive Limits
---
Auto Ignition Temperature
524 °C
Decomposition Temperature
Not applicable
Solubility
---
Partition Coefficient
-0.34 (20 °C; IUCLID)
Solubility In Water
soluble (20 °C)
Solubility In Fat
---
Molecular Weight
---
Voc Content
---
Metal Corrosion
---
Dynamic Viscosity
0.316 mPa*s (25 °C)
Kinematic Viscosity
---
Properties Status
---
10

Stability and Reactivity

Chemical stability, hazardous reactions, and incompatible materials

Stability

The product is chemically stable under standard ambient conditions (room temperature).

Reactivity

Vapour can form explosive mixtures with air. Risk of ignition. In case of warming: Risk of ignition.

Hazardous reactions

Violent reaction with: Oxidising agent, Reducing agent, Acid, Alkali metals, Peroxides

Avoid

This material is combustible and can be ignited by heat, sparks, flames, or other sources of ignition (e.g. static electricity, pilot lights, or mechanical/electrical equipment). Avoid high temperatures or direct sunlight.

Incompatible

Rubber articles, Plastic articles

Decomposition

Decomposition products in case of fire: see section 5.

12

Ecological Information

Environmental toxicity, biodegradation, and bioaccumulation data

The data for this section has not been processed yet.

13

Disposal Considerations

Waste treatment methods, disposal recommendations, and waste codes

The data for this section has not been processed yet.

14

Transport Information

UN numbers, shipping names, transport classes, and regulatory requirements

UN Number
1648
Shipping Name
ACETONITRILE
Transport Class
3
Packing Group
II
ADR

Hazard identification number (Kemler No.): 33 Tunnel restriction code: D/E (Passage forbidden through tunnels of category D when carried in bulk or in tanks. Passage forbidden through tunnels of category E.)

IMDG

Segregation group: -

15

Regulatory Information

Chemical regulations, safety assessments, and compliance status

The data for this section has not been processed yet.

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Frequently Asked Questions

Common questions about safety, handling, and properties

What other names is Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments known by?

Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments is also known as: Cyanomethane, Ethanenitrile, Ethanoic acid nitrile, Methyl cyanide

What is the hazard signal word for Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments?

The signal word is danger.

What is the physical form of Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments?

Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments is a liquid with colourless color. It has ether-like odor.

What is Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments used for?

General chemical reagent

What are the hazard statements for Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments?

This substance has 3 hazard statements:

  • H225: Highly flammable liquid and vapour.
  • H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.
  • H319: Causes serious eye irritation.

What is the melting point of Acetonitrile HiPerSolv CHROMANORM® for HPLC LC-MS grade - suitable for UPLC/UHPLC instruments?

The melting point is -45.7 °C and the boiling point is 81.6 °C (1013 hPa).